Table 1 Ontology and downregulation levels of 51 potential PAX3/FKHR target genes

From: Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR

Gene name Common Description Downregulation 24 h (fold) Function
Signal transduction
 207232_s_at DZIP3 Zinc-finger DAZ interacting protein 3 6.1 Ligase activity, protein ubiquitination, RNA binding, zinc ion binding
 220197_at ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a isoform 4 5.7 Ion transport, proton transport, regulation of pH
 204882_at ARHGAP25 Rho GTPase-activating protein 25 4.2 GTPase activator activity
 203638_s_at FGFR2 Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson–Weiss syndrome) 3.2 Cell growth, protein amino-acid phosphorylation
 206723_s_at EDG4 Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 2.9 G-protein coupled receptor protein signaling pathway, lysosphingolipid and lysophosphatidic acid receptor activity, lipid binding
 212915_at SEMACAP3 Likely ortholog of mouse semaF cytoplasmic domain associated protein 3 2.7 Metal ion binding, protein ubiquitination, ubiquitin-protein ligase activity
 203233_at IL4R Interleukin 4 receptor 2.6 Immune response, receptor signaling protein activity
 209869_at ADRA2A Adrenergic, α-2A-, receptor 2.5 Activation of MAPK activity, Ras protein signal transduction, positive regulation of cell proliferation
 213436_at CNR1; CB1; CB-R; CB1A; CANN6; CB1K5 Cannabinoid receptor 1 (brain) 2.3 Cannabinoid receptor activity, G-protein signaling, coupled to cyclic nucleotide second messenger
 205068_s_at GRAF GTPase regulator associated with focal adhesion kinase pp125 (FAK) 1.9 Nervous system development, Rho GTPase activator activity
 221578_at RASSF4 RAS association (RalGDS/AF-6) domain family 4 1.8 Oxidoreductase activity
 200972_at TM4SF8 Transmembrane 4 superfamily member 8 1.7 Cell motility, cell proliferation
 218373_at FTS Fused toes homolog (mouse) 1.6 Apoptosis, ubiquitin-like activating enzyme activity
DNA binding
 202320_at GTF3C1 General transcription factor IIIC, polypeptide 1, α 220 kDa 9.6 DNA binding, RNA polymerase III transcription factor activity, rRNA transcription, tRNA transcription
 205935_at FOXF1 Forkhead box F1 2.8 Regulation of transcription, DNA- dependent; regulation of transcription from Pol II promoter
 209757_s_at MYCN V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 2.8 Transcription factor activity, protein binding, regulation of transcription, DNA-dependent
 206940_s_at POU4F1 POU domain, class 4, transcription factor 1 2.7 Development, transcription factor activity, regulation of transcription from Pol II promoter
 218445_at H2AFY2 H2A histone family, member Y2 2.6 Dosage compensation
 214451_at TFAP2B Transcription factor AP-2β (activating enhancer binding protein 2β) 2.6 Nervous system development, transcription factor activity, transcription coactivator activity
 211341_at POU4F1 POU domain, class 4, transcription factor 1 2.4 Development, transcription factor activity, regulation of transcription from Pol II promoter
Enzymes
 212989_at MOB Mob protein 3.4 Kinase activity, lipid metabolism, transferase activity
 214961_at KIAA0774 KIAA0774 3.1 Catalytic activity
 221605_s_at PIPOX Pipecolic acid oxidase 3.0 Electron transport, oxidoreductase activity, tetrahydrofolate metabolism
 206447_at ELA1 Elastase 1, pancreatic 3.0 Trypsin activity, pancreatic elastase activity, hydrolase activity
 209460_at ABAT 4-Aminobutyrate aminotransferase 2.9 Transferase activity, neurotransmitter catabolism
 209765_at ADAM19 A disintegrin and metalloproteinase domain 19 (meltrin β) 2.5 Hydrolase activity; metalloendopeptidase activity, proteolysis
 212006_at UBXD2 UBX domain containing 2 2.3 Regulation of transcription, DNA- dependent, transcription factor activity
 204074_s_at KIAA0562 Glycine-, glutamate-, thienylcyclohexylpiperidine- binding protein 2.2 Binding, hydrolase activity
 205811_at POLG2 Polymerase (DNA directed), γ2, accessory subunit 1.9 DNA repair, DNA-dependent DNA replication, protein biosynthesis, metallopeptidase activity
 202603_at ADAM10 A disintegrin and metalloproteinase domain 10 1.9 Hydrolase activity, protein amino-acid phosphorylation, metalloendopeptidase activity
Cell growth and/or maintenance
 205430_at BMP5 Continued from bA120K22.1 in Em:AL137178 match: proteins: Tr:Q9YGH7 Sw:P22003 Sw:P22004 Sw:P20722 Tr:Q91403 Sw:P30886 Sw:P49003 Sw:Q04906 Sw:P18075 Sw:P23359; human DNA sequence from clone RP1-181C24 on chromosome 6p11.1-12.2 contains the 3′ end of the BM 6.2 Cell differentiation, cytokine activity, growth, growth factor activity, skeletal development
 209814_at ZNF330 Zinc-finger protein 330 2.9 Metal ion binding, protein binding, zinc ion binding
 203651_at ZFYVE16 Zinc finger, FYVE domain containing 16 1.9 Endosome transport, metal ion binding, protein targeting to lysosome, regulation of endocytosis, vesicle organization and biogenesis
Structural molecules
 221854_at PKP1 Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 8.0 Cell–cell signaling, cell adhesion
 203256_at CDH3 Cadherin 3, type 1, P-cadherin (placental) 6.0 Cell adhesion, calcium ion binding
 203072_at MYO1E Myosin IE 2.1 Actin binding, ATP binding, ATPase activity, actin filament-based movement
 211059_s_at GOLGA2 Golgi autoantigen, golgin subfamily a, 2 1.7 Protein binding
Neuronal
 206089_at NELL1 NEL-like 1 (chicken) 4.7 Nervous system development, cell adhesion
 204105_s_at NRCAM Neuronal cell adhesion molecule 3.5 Ankyrin binding, cell–cell adhesion, neuron migration, positive regulation of neuron differentiation, protein binding, synaptogenesis
Unknown
 210102_at LOH11CR2A Loss of heterozygosity, 11, chromosomal region 2, gene A 2.7 Unknown
 221185_s_at DKFZp434B227 Synonyms: FLJ11667, FLJ23571; Homo sapiens hypothetical protein DKFZp434B227 (DKFZp434B227), mRNA. 2.6 Unknown
 205888_s_at KIAA0555 KIAA0555 gene product 2.5 Unknown
 213179_at   602381329F1 NIH_MGC_93 Homosapiens cDNA clone IMAGE:4499023 5′, mRNA sequence. 2.4 Unknown
 209693_at ASTN2 Astrotactin 2 2.4 Unknown
 219438_at FLJ12650 Hypothetical protein FLJ12650 2.3 Unknown
 220610_s_at LRRFIP2 Leucine rich repeat (in FLII) interacting protein 2 2.3 Unknown
 207759_s_at FLJ41105 Hypothetical gene supported by AK123100 2.2 Unknown
 49111_at   MRNA; cDNA DKFZp762M127 (from clone DKFZp762M127) 2.2 Unknown
 43511_s_at   MRNA; cDNA DKFZp762M127 (from clone DKFZp762M127) 1.9 Unknown
 212736_at BC008967 Hypothetical gene BC008967 1.8 Unknown
 219225_at PGBD5 PiggyBac transposable element derived 5 1.6 Unknown