Table 2 Comparison of MCC promoter methylation with other molecular variables

From: Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer

  MCC Methylated MCC Unmethylated Total number of patients P
CIMP+ 21 (100) 0 (0) 21 <0.0001
CIMP− 18 (25.7) 52 (74.3) 70  
CDKN2A
 Methylated 23 (88.5) 3 (11.5) 26 <0.0001
 Unmethylated 16 (24.6) 49 (75.4) 65  
APC
 Methylated 11 (52.4) 10 (47.6) 21 0.3191
 Unmethylated 26 (40.0) 39 (60.0) 65  
MSI-H 12 (63.2) 7 (36.8) 19  
MSI-L/MSS 27 (37.5) 45 (62.5) 72 0.0444
BRAF V600E mutation
 Yes 17 (100) 0 (0) 17 <0.0001
 No 22 (29.7) 52 (70.3) 74  
KRAS codon 12/13 mut.
 Yes 9 (34.6) 17 (65.4) 26 0.356
 No 30 (46.2) 35 (53.8) 65  
Proximal colon 20 (55.6) 16 (44.4) 36  
Distal colon 17 (34.7) 32 (65.3) 49 0.0553
Stage A 1 (50.0) 1 (50.0) 2  
Stage B 15 (34.9) 28 (65.1) 43  
Stage C 10 (45.5) 12 (54.5) 22  
Stage D 7 (50.0) 7 (50.0) 14 0.7098
  1. Abbreviations: APC: adenomatous polyposis coli; CIMP: CpG island methylator phenotype; MCC: mutated in colorectal cancer; MSI-H: high microsatellite instability; MSI-L, low microsatellite instability; MSS, microsatellite stable.