Table 1 Papilloma incidence in the congenic lines

From: Convergence of congenic mapping and allele-specific alterations in tumors for the resolution of the Skts1 skin tumor susceptibility locus

Congenic line Chromosomal region (cM) a Backcross Intercross
   NS b NN b P-valuec SS b NN b P-valuec
3540 15.4–28.9 12.5 (133; n=20) 22 (438; n=18) 2.4E-03 6 (121; n=14) 15 (228; n=20) 8.0E-04
A62 1828.9 11 (032; n=19) 22 (436; n=19) 2.1E-03 4 (019; n=16) 15 (232; n=15) 5.3E-04
717 1821.8 14 (032; n=17) 24 (1435; n=13) 1.5E-03 6 (019; n=17) 15 (427; n=19) 1.9E-04
B6F 1819.3 17 (531; n=12) 20 (541; n=14) 0.16 14 (036; n=17) 14 (428; n=16) 0.40
C3F 20.928.9 6.5 (029; n=12) 22.5 (436; n=18) 4.6E-03 2 (011; n=13) 17 (432; n=16) 2.9E-05
454 25.428.9 20 (237; n=13) 23 (641; n=19) 0.24 15 (228; n=16) 12 (127; n=23) 0.19
314 27.628.9 18.5 (434; n=8) 23 (636; n=11) 0.15 ND ND ND
D0F 1.719.3 ND ND ND 10 (121; n=19) 14.5 (131; n=22) 0.03
150 15.417 ND ND ND 10 (120; n=17) 15 (233; n=17) 0.03
260 15.418 ND ND ND 11 (020; n=16) 12 (324; n=26) 0.16
381 20.925.4 ND ND ND 5.5 (017; n=26) 14.5 (427; n=20) 3.7E-05
383 20.926.7 ND ND ND 1 (010; n=23) 13.5 (445; n=22) 1.4E-08
1230 20.921.8 ND ND ND 8 (029; n=16) 25 (20–32; n=10) 2.4E-04
  1. Abbreviations: ND, not determined; SSLP, simple sequence length polymorphism.
  2. aRegion of chromosome 7 for which the congenic lines contain M. spretus alleles is indicated in cM based on the location of SSLP markers as determined with the described NIH/Ola × M. spretus backcrosses (n>1000).
  3. bMedian values for papilloma numbers (with range and number of mice in parenthesis) 20 weeks after tumor initiation are shown per genotype.
  4. cP-values for comparison of papilloma numbers in mice heterozygous NIH/Ola-M. spretus (NS; backcross) or homozygous NIH/Ola (NN, backcross), or for comparison of papilloma numbers in the reciprocal homozygotes (NN or SS) in the same congenic lines (Wilcoxon rank sum test).