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  • Oncogenomics
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UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas

Oncogene volume 26, pages 2136–2140 (2007)Cite this article

Abstract

The UbcH10 gene codes for a protein that belongs to the ubiquitin-conjugating enzyme family. Previous studies of our group suggest UbcH10 expression as a valid indicator of the proliferative and aggressive status of thyroid carcinomas. Therefore, to better understand the process of ovarian carcinogenesis, and to look for possible tools to be used as prognostic markers in these neoplasias, we decided to extend the analysis of the UbcH10 expression to the ovarian neoplastic disease. We found that the UbcH10 gene was upregulated in some ovarian carcinoma cell lines analysed. Then, immunohistochemical studies demonstrate that UbcH10 expression significantly correlates with the tumor grade and the undifferentiated histotype of the ovarian carcinomas. Furthermore, a significant relationship between UbcH10 expression and overall survival was observed. Finally, the block of UbcH10 protein synthesis by RNA interference inhibited the growth of ovarian carcinoma cell lines, suggesting a role of UbcH10 overexpression in ovarian carcinogenesis. Therefore, all these data taken together suggest the possibility to use UbcH10 detection as a marker for the diagnosis and prognosis of these neoplastic diseases and open the perspective of a therapy of some ovarian carcinomas based on the suppression of the UbcH10 synthesis and/or function.

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Acknowledgements

This work was supported by grants from the Associazione Italiana Ricerca sul Cancro (AIRC), Progetto Strategico Oncologia Consiglio Nazionale delle Ricerche, the Ministero dell'Università e della Ricerca Scientifica e Tecnologica (MIUR), and ‘Piani di Potenziamento della Rete Scientifica e Tecnologica’ CLUSTER C-04, the Programma Italia-USA sulla Terapia dei Tumori coordinated by Professor Cesare Peschle and ‘Ministero della Salute’. This work was supported from NOGEC-Naples Oncogenomic Center. We thank the Associazione Partenopea per le Ricerche Oncologiche (APRO) for its support.

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Authors and Affiliations

  1. Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Naples, Italy

    M T Berlingieri, P Pallante & A Fusco

  2. Dipartimento di Ginecologia e Ostetricia, e Fisiopatologia della Riproduzione Umana, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Naples, Italy

    M Guida & C Nappi

  3. Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del S.Cuore, Rome, Italy

    V Masciullo & G Scambia

  4. NOGEC (Naples Oncogenomic Center)-CEINGE, Biotecnologie Avanzate-Napoli, & SEMM – European School of Molecular Medicine – Naples Site, Naples, Italy

    A Ferraro, V Leone & A Fusco

  5. Bioinformatics – SRA Division ITC-irst, Centre for Scientific and Technological Research, Povo (Trento), Italy

    A Sboner

  6. U.O. Anatomia Patologica Ospedale S. Chiara Largo Medaglie d'Oro Trento, Italy

    M Barbareschi & A Ferro

  7. Dipartimento di Anatomia Patologica e Citopatologia, Facoltà di Medicina e Chirurgia, Università di Napoli ‘Federico II’, Naples, Italy

    G Troncone

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  1. M T Berlingieri
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  2. P Pallante
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  3. M Guida
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  4. C Nappi
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  7. A Ferraro
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  8. V Leone
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  9. A Sboner
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  10. M Barbareschi
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  12. G Troncone
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  13. A Fusco
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Corresponding author

Correspondence to A Fusco.

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Berlingieri, M., Pallante, P., Guida, M. et al. UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas. Oncogene 26, 2136–2140 (2007). https://doi.org/10.1038/sj.onc.1210010

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  • DOI: https://doi.org/10.1038/sj.onc.1210010

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