Micro-RNAs (miRNAs) are a class of approximately 22-nucleotide non-coding RNAs expressed in multicellular organisms. They are first transcribed in a similar manner to pre-mRNAs. The transcripts then go through a series of processing steps, including endonucleolytic cleavage, nuclear export and a strand selection procedure, to yield the single-stranded mature miRNA products. The transcription and processing of miRNAs determines the abundance and the sequence of mature miRNAs and has important implications for the function of miRNAs.
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I thank B Cullen for comments and E Wessel for help in preparing the figures.
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Zeng, Y. Principles of micro-RNA production and maturation. Oncogene 25, 6156–6162 (2006). https://doi.org/10.1038/sj.onc.1209908
- micro-RNA processing
- precursor miRNAs
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