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A redox cycle within the cell cycle: ring in the old with the new

Oncogene volume 26, pages 1101–1109 (2007)Cite this article

Abstract

In recent years, the intracellular oxidation–reduction (redox) state has gained increasing attention as a critical mediator of cell signaling, gene expression changes and proliferation. This review discusses the evidence for a redox cycle (i.e., fluctuation in the cellular redox state) regulating the cell cycle. The presence of redox-sensitive motifs (cysteine residues, metal co-factors in kinases and phosphatases) in several cell cycle regulatory proteins indicate periodic oscillations in intracellular redox state could play a central role in regulating progression from G0/G1 to S to G2 and M cell cycle phases. Fluctuations in the intracellular redox state during cell cycle progression could represent a fundamental mechanism linking oxidative metabolic processes to cell cycle regulatory processes. Proliferative disorders are central to a variety of human pathophysiological conditions thought to involve oxidative stress. Therefore, a more complete understanding of redox control of the cell cycle could provide a biochemical rationale for manipulating aberrant cell proliferation.

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Acknowledgements

We thank Ms Kellie Bodeker with editorial assistance. This work was supported by funding from NIH CA 111365 and The University of Iowa Carver Trust.

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  1. Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA, USA

    S G Menon & P C Goswami

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Menon, S., Goswami, P. A redox cycle within the cell cycle: ring in the old with the new. Oncogene 26, 1101–1109 (2007). https://doi.org/10.1038/sj.onc.1209895

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