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The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

Abstract

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 appears to involve regulating the function of RAD51 in the repair by homologous recombination. BRCA1 has a broader role upstream of BRCA2, participating in various cellular processes in response to DNA damage. The DNA repair defect associated with mutations in BRCA1 or BRCA2 could be exploited to develop new targeted therapeutic approaches for cancer occurring in mutation carriers.

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Acknowledgements

We are grateful to the members of the Ashworth laboratory for useful comments during the writing of this review, with special thanks to Nuala McCabe. Work in our laboratory is funded by Breakthrough Breast Cancer and Cancer Research UK.

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Gudmundsdottir, K., Ashworth, A. The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene 25, 5864–5874 (2006). https://doi.org/10.1038/sj.onc.1209874

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  • DOI: https://doi.org/10.1038/sj.onc.1209874

Keywords

  • BRCA1
  • BRCA2
  • repair
  • genomic stability
  • DSS1

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