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Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus

Oncogene volume 25, pages 5294–5301 (2006)Cite this article

Abstract

Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses need the cell cycle machinery of the host cell to complete their replication; so they evolved mechanisms that can interfere with the growth control of infected cells and force them into DNA replication. The retinoblastoma family of proteins (pRb), which includes pRb/p105, p107 and pRb2/p130, acts as one of the most important regulators of the G1/S transition of the cell cycle. Rb proteins represent an important target for viral oncoproteins. Early viral T antigens can bind all members of the pRb family, promoting the activation of the E2F family of transcription factors, thus inducing the expression of genes required for the entry to the S phase.The interaction between early viral antigens and cell cycle regulators represents an important mechanism through which viruses deregulate cell cycle and lead to cell transformation. In this review, we will discuss the effects of the interaction between large T antigen and Rb proteins in JC virus-mediated oncogenesis.

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Authors and Affiliations

  1. Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA, USA

    V Caracciolo, G De Falco & A Giordano

  2. Department of Neuroscience, Center for Neurovirology, Temple University, Philadelphia, PA, USA

    K Reiss & K Khalili

  3. Department of Human Pathology and Oncology, University of Siena, Siena, Italy

    G De Falco & A Giordano

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  1. V Caracciolo
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Correspondence to A Giordano.

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Caracciolo, V., Reiss, K., Khalili, K. et al. Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus. Oncogene 25, 5294–5301 (2006). https://doi.org/10.1038/sj.onc.1209681

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