Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The permeability transition pore complex in cancer cell death

A Corrigendum to this article was published on 26 October 2006

Abstract

The permeability transition pore (PTP) is a multi-protein complex at contact sites of the inner with the outer mitochondrial membrane. Research over the past years has led to the concept that the PTP occupies a central role in cell death induction. Numerous apoptosis signals convert this protein aggregate into an unspecific pore, thus activating mitochondria for the cellular self-destruction process. Here, we describe the evidence for this and the various approaches being undertaken to elucidate its subunit composition and mode of regulation. In particular, we review data that indicate a role of specific PTP subunits for apoptosis inhibition during tumorigenesis.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1
Figure 2

Abbreviations

ADP:

adenosine diphosphate

ANT:

adenine nucleotide translocase

ATP:

adenosine 5′ triphosphate

Atr:

atractyloside

BA:

bongrekic acid

CK:

creatine kinase

CsA:

cyclosporin A

CypD:

Cyclophilin D

ΔΨm:

inner transmembrane potential

HK:

hexokinase

IM:

inner membrane

MEF:

mouse embryonic fibroblasts

OM:

outer membrane

PBR:

peripheral benzodiazepine receptor

PT:

permeability transition

PTP:

permeability transition pore

ROS:

reactive oxygen species

t-BHP:

tert-butylhydroperoxide

TNF:

tumor necrosis factor

VDAC:

voltage-dependent anion channel

References

  • Adrain C, Martin SJ . (2001). Trends Biochem Sci 26: 390–397.

  • Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V . (2004). Biochem J 377: 347–355.

  • Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA et al. (2005). Nature 434: 658–662.

  • Banker D, Cooper J, Fennell D, Willman C, Appelbaum F, Cotter F . (2002). Leukemia Res 26: 91–106.

  • Barros LF, Hermosilla T, Castro J . (2001). Comp Biochem Physiol A Mol Integr Physiol 130: 401–409.

  • Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, Bernardi P . (2005). J Biol Chem 280: 18558–18561.

  • Bauer MK, Schubert A, Rocks O, Grimm S . (1999). J Cell Biol 147: 1493–1502.

  • Belzacq A, Vieira H, Verrier F, Vandecasteele G, Cohen I, Prevost M et al. (2003). Cancer Res 63: 541–546.

  • Belzacq AS, El Hamel C, Vieira HL, Cohen I, Haouzi D, Metivier D et al. (2001a). Oncogene 20: 7579–7587.

  • Belzacq AS, Jacotot E, Vieira HL, Mistro D, Granville DJ, Xie Z et al. (2001b). Cancer Res 61: 1260–1264.

  • Belzacq AS, Vieira HL, Kroemer G, Brenner C . (2002). Biochimie 84: 167–176.

  • Bernardi P . (1996). Biochim Biophys Acta Bioenergetics 1275: 5–9.

  • Beutner G, Ruck A, Riede B, Welte W, Brdiczka D . (1996a). FEBS Lett 396: 189–195.

  • Beutner G, Rück A, Riede B, Welte W, Brdiczka D . (1996b). FEBS Lett 396: 189–195.

  • Biaglow JE, Miller RA . (2005). Cancer Biol Ther 4: 6–13.

  • Boisvieux-Ulrich E, Sourdeval M, Marano F . (2005). Exp Cell Res 307: 76–90.

  • Bonod-Bidaud C, Chevrollier A, Bourasseau I, Lachaux A, Mousson de Camaret B, Stepien G . (2001). Mitochondrion 1: 217–224.

  • Brdiczka D . (1991). Biochim Biophys Acta 1071: 291–312.

  • Brenner C, Cadiou H, Vieira HL, Zamzami N, Marzo I, Xie Z et al. (2000a). Oncogene 19: 329–336.

  • Brenner C, Marzo I, de Araujo Vieira HL, Kroemer G . (2000b). Methods Enzymol 322: 243–252.

  • Broekemeier KM, Dempsey ME, Pfeiffer DR . (1989). J Biol Chem 264: 7826–7830.

  • Brustovetsky N, Tropschug M, Heimpel S, Heidkamper D, Klingenberg M . (2002). Biochemistry 41: 11804–11811.

  • Buttke TM, Sandstrom PA . (1994). Immunol Today 15: 7–10.

  • Cassarino DS, Bennett Jr JP . (1999). Brain Res Brain Res Rev 29: 1–25.

  • Cassarino DS, Parks JK, Parker WD, Bennett JP . (1999). Biochim Biophys Acta – Mole Basis Dis 1453: 49–62.

  • Catasus L, Matias-Guiu X, Machin P, Zannoni GF, Scambia G, Benedetti-Panici P et al. (2000). Cancer 88: 2290–2297.

  • Cesar Md Mde C, Wilson J . (2004). Arch Biochem Biophys 422: 191–196.

  • Chakraborti T, Mondal M, Roychoudhury S, Chakraborti S . (1999). Cell Signal 11: 77–85.

  • Chandra J, Mansson E, Gogvadze V, Kaufmann S, Albertioni F, Orrenius S . (2002). Blood 99: 655–663.

  • Cheng E, Sheiko T, Fisher J, Craigen W, Korsmeyer S . (2003). Science 301: 513–517.

  • Clarke SJ, McStay GP, Halestrap AP . (2002). J Biol Chem 277: 34793–34799.

  • Clement MV, Pervaiz S . (1999). Free Radical Res 30: 247–252.

  • Costantini P, Belzacq AS, Vieira HL, Larochette N, de Pablo MA, Zamzami N et al. (2000). Oncogene 19: 307–314.

  • Crompton M . (2000). J Physiol 529: 11–21.

  • Crompton M, Barksby E, Johnson N, Capano M . (2002). Biochimie 84: 143–152.

  • Crompton M, Virji S, Ward JM . (1998). Eur J Biochem 258: 729–735.

  • De Giorgi F, Lartigue L, Bauer MK, Schubert A, Grimm S, Hanson GT et al. (2002). FASEB J 16: 607–609.

  • Debatin KM, Poncet D, Kroemer G . (2002). Oncogene 21: 8786–8803.

  • Decaudin D, Castedo M, Nemati F, Beurdeley-Thomas A, De Pinieux G, Caron A et al. (2002). Cancer Res 62: 1388–1393.

  • DeLuca M, Hall N, Rice R, Kaplan NO . (1981). Biochem Biophys Res Commun 99: 189–195.

  • Deniaud A, Hoebeke J, Briand J, Muller S, Jacotot E, Brenner C . (2006). Curr Pharm Des in press.

  • Don A, Kisker O, Dilda P, Donoghue N, Zhao X, Decollogne S et al. (2003). Cancer Cell 3: 497–509.

  • Dvorakova K, Payne C, Tome M, Briehl M, Vasquez M, Waltmire C et al. (2002). Mol Cancer Ther 1: 185–195.

  • Eldering E, Mackus W, Derks I, Evers L, Beuling E, Teeling P et al. (2004). Eur J Immunol 34: 1950–1960.

  • Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD et al. (1999). Nat Med 5: 1032–1038.

  • Elmore S, Qian T, Grissom SF, JJ L . (2001). FASEB J 15: 2286–2287.

  • Ermak G, Davies KJ . (2002). Mol Immunol 38: 713–721.

  • Eskes R, Antonsson B, Osensand A, Montessuit S, Richter C, Sadoul R et al. (1998). J Cell Biol 143: 217–224.

  • Fantin V, Berardi M, Scorrano L, Korsmeyer S, Leder P . (2002). Cancer Cell 2: 29–42.

  • Faure Vigny H, Heddi A, Giraud S, Chautard D, Stepien G . (1996). Mol Carcinogen 16: 165–172.

  • Faustin B, Rossignol R, Rocher C, Benard G, Malgat M, Letellier T . (2004). J Biol Chem 279: 20411–20421.

  • Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR . (1999a). J Biol Chem 274: 2225–2233.

  • Finucane DM, Waterhouse NJ, Amarante-Mendes GP, Cotter TG, Green DR . (1999b). Exp Cell Res 251: 166–174.

  • Friberg H, Wieloch T . (2002). Biochimie 84: 241–250.

  • Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME et al. (1998). J Biol Chem 273: 33942–33948.

  • Genini D, Adachi S, Chao Q, Rose DW, Carrera CJ, Cottam HB et al. (2000). Blood 96: 3537–3543.

  • Gewies A, Grimm S . (2003). Cancer Res 63: 682–688.

  • Giraud S, Bonod-Bidaud C, Wesolowski-Louvel M, Stepien G . (1998). J Mol Biol 281: 409–418.

  • Green DR, Evan GI . (2002). Cancer Cell 1: 19–30.

  • Green DR, Kroemer G . (2004). Science 305: 626–629.

  • Gudnason V, Ingvarsson S, Jonasdottir A, Andresdottir V, Egilsson V . (1984). Int J Cancer 34: 63–66.

  • Halestrap A . (2005). Nature 434: 578–579.

  • Halestrap AP . (2004). Nature 430: 1 p following 983.

  • Halestrap AP, Clarke SJ, Javadov SA . (2004). Cardiovasc Res 61: 372–385.

  • Halestrap AP, Connern CP, Griffiths EJ, Kerr PM . (1997a). Mol Cell Biochem 174: 167–172.

  • Halestrap AP, Woodfield KY, Connern CP . (1997b). J Biol Chem 272: 3346–3354.

  • Halliwell B . (1999). Free Radical Res 31: 261–272.

  • Halliwell B, Gutteridge JMC . (1999). Free Radicals in Biology and Medicine, 3rd edn. Clarendon Press: Oxford, England.

    Google Scholar 

  • Hanahan D, Weinberg RA . (2000). Cell 100: 57–70.

  • Haouzi D, Cohen I, Vieira HL, Poncet D, Boya P, Castedo M et al. (2002). Apoptosis 7: 395–405.

  • Hardwick M, Fertikh D, Culty M, Li H, Vidic B, Papadopoulos V . (1999). Cancer Res 59: 831–842.

  • Haridas V, Higuchi M, Jayatilake G, Bailey D, Mujoo K, Blake M et al. (2001). Proc Natl Acad Sci USA 98: 5821–5826.

  • Harris AL . (2002). Nat Rev Cancer 2: 38–47.

  • Hayes J, Pulford D . (1995). Crit Rev Biochem Mol Biol 30: 445–600.

  • Heerdt B, Houston M, Wilson A, Augenlicht L . (2003). Cancer Res 63: 6311–6319.

  • Hirsch T, Decaudin D, Susin SA, Marchetti P, Larochette N, Resche-Rigon M et al. (1998a). Exp Cell Res 241: 426–434.

  • Hirsch T, Decaudin D, Susin SA, Marchetti P, Larochette N, Rescherigon M et al. (1998b). Exp Cell Res 241: 426–434.

  • Hunter DR, Haworth RA, Southard JH . (1976). J Biol Chem 251: 5069–5077.

  • Inoue K, Kohno T, Takakura S, Hayashi Y, Mizoguchi H, Yokota J . (2001). Leukemia Res 25: 275–278.

  • Ionov Y, Yamamoto H, Krajewski S, Reed JC, Perucho M . (2000). Proc Natl Acad Sci USA 97: 10872–10877.

  • Jacotot E, Ferri KF, El Hamel C, Brenner C, Druillennec S, Hoebeke J et al. (2001). J Exp Med 193: 509–519.

  • Jan G, Belzacq AS, Haouzi D, Rouault A, Metivier D, Kroemer G et al. (2002). Cell Death Differ 9: 179–188.

  • Katz Y, Ben-Baruch G, Kloog Y, Menczer J, Gavish M . (1990). Clin Sci (Lond) 78: 155–158.

  • Kim J, Qian T, Lemasters J . (2003). Gastroenterology 124: 494–503.

  • Kim JS, He L, Qian T, Lemasters JJ . (2003). Curr Mol Med 3: 527–535.

  • Ko YH, Delannoy M, Hullihen J, Chiu W, Pedersen PL . (2003). J Biol Chem 278: 12305–12309.

  • Kokoszka JE, Waymire KG, Levy SE, Sligh JE, Cai J, Jones DP et al. (2004). Nature 427: 461–465.

  • Kon K, Kim JS, Jaeschke H, Lemasters JJ . (2004). Hepatology 40: 1170–1179.

  • Kornblau SM, Thall PF, Estrov Z, Walterscheid M, Patel S, Theriault A et al. (1999). Clin Cancer Res 5: 1758–1766.

  • Kowaltowski AJ, Verseci AE, Castilho RF . (1997). Biochim Biophys Acta 1318: 395–402.

  • Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P et al. (2005). Cell Death Differ 12 (Suppl 2): 1463–1467.

  • Kubasiak L, Hernandez O, Bishopric N, Webster K . (2002). Proc Natl Acad Sci USA 99: 12825–12830.

  • Larochette N, Decaudin D, Jacotot E, Brenner C, Marzo I, Susin SA et al. (1999). Exp Cell Res 249: 413–421.

  • Le Bras M, Clement MV, Pervaiz S, Brenner C . (2005). Histol Histopathol 20: 205–220.

  • Lehenkari P, Kellinsalmi M, Napankangas J, Ylitalo K, Monkkonen J, Rogers M et al. (2002). Mol Pharmacol 61: 1255–1262.

  • Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P . (1997). J Exp Med 185: 1481–1486.

  • Lemasters J, Nieminen A, Qian T, Trost L, Herman B . (1997). Mol Cell Biochem 174: 159–165.

  • Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y et al. (1998). Biochim Biophys Acta 1366: 177–196.

  • Levin E, Premkumar A, Veenman L, Kugler W, Leschiner S, Spanier I et al. (2005). Biochemistry 44: 9924–9935.

  • Li Y, Johnson N, Capano M, Edwards M, Crompton M . (2004). Biochem J 383: 101–109.

  • Lin DT, Lechleiter JD . (2002). J Biol Chem 277: 31134–31141.

  • Los M, Mozoluk M, Ferrari D, Stepczynska A, Stroh C, Renz A et al. (2002). Mol Biol Cell 13: 978–988.

  • Maaser K, Grabowski P, Oezdem Y, Krahn A, Heine B, Stein H et al. (2005a). Clin Cancer Res 11: 1751–1756.

  • Maaser K, Sutter A, Scherubl H . (2005b). Biochem Biophys Res Commun 332: 646–652.

  • Machida K, Hayashi Y, Osada H . (2002). J Biol Chem 277: 31243–31248.

  • Madeo F, Herker E, Wissing S, Jungwirth H, Eisenberg T, Frohlich KU . (2004). Curr Opin Microbiol 7: 655–660.

  • Manion MK, Hockenbery DM . (2003). Cancer Biol Ther 2: S105–S114.

  • Marchetti P, Castedo M, Susin SA, Zamzami N, Hirsch T, Macho A et al. (1996). J Exp Med 184: 1155–1160.

  • Marchetti P, Zamzami N, Joseph B, Schraen-Maschke S, Mereau-Richard C, Costantini P et al. (1999). Cancer Res 59: 6257–6266.

  • Marzo I, Brenner C, Zamzami N, Jurgensmeier JM, Susin SA, Vieira HL et al. (1998a). Science 281: 2027–2031.

  • Marzo I, Brenner C, Zamzami N, Susin SA, Beutner G, Brdiczka D et al. (1998b). J Exp Med 187: 1261–1271.

  • Marzo I, Susin SA, Petit PX, Ravagnan L, Brenner C, Larochette N et al. (1998). FEBS Lett 427: 198–202.

  • Meijerink JP, Mensink EJ, Wang K, Sedlak TW, Sloetjes AW, de Witte T et al. (1998). Blood 91: 2991–2997.

  • Miettinen H, Kononen J, Haapasalo H, Helen P, Sallinen P, Harjuntausta P et al. (1995). Cancer Res 55: 2691–2695.

  • Morgan J, Oseroff AR, Cheney RT . (2004). Br J Dermatol 151: 846–856.

  • Mund T, Gewies A, Schoenfeld N, Bauer MK, Grimm S . (2003). FASEB J 17: 696–698.

  • Nagahara Y, Ikekita M, Shinomiya T . (2000). J Immunol 165: 3250–3259.

  • Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H et al. (2005). Nature 434: 652–658.

  • Nakamura Y, Kawakami M, Yoshihiro A, Miyoshi N, Ohigashi H, Kawai K et al. (2002). J Biol Chem 277: 8492–8499.

  • Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H et al. (1998). Proc Natl Acad Sci USA 95: 14681–14686.

  • Nieminen AL, Byrne AM, Herman B, Lemasters JJ . (1997). Am J Physiol 272: C1286–C1294.

  • Nieminen AL, Saylor AK, Tesfai SA, Herman B, Lemasters JJ . (1995). Biochem J 307 (Part 1): 99–106.

  • Okami J, Simeone DM, Logsdon CD . (2004). Cancer Res 64: 5338–5346.

  • Oudard S, Carpentier A, Banu E, Fauchon F, Celerier D, Poupon M et al. (2003). J Neurooncol, 81–86.

  • Palmieri F . (2004). Pflugers Arch 447: 689–709.

  • Pani G, Colavitti R, Bedogni B, Fusco S, Ferraro D, Borrello S et al. (2004). Curr Med Chem 11: 1299–1308.

  • Pastorino JG, Shulga N, Hoek JB . (2002). J Biol Chem 277: 7610–7618.

  • Pelicano H, Carney D, Huang P . (2004). Drug Resist Update 7: 97–110.

  • Pervaiz S, Seyed MA, Hirpara JL, Clement MV, Loh KW . (1999). Blood 93: 4096–4108.

  • Peter ME, Krammer PH . (2003). Cell Death Differ 10: 26–35.

  • Petit PX, LeCoeur H, Zorn E, Dauguet C, Mignotte B, Gougeon ML . (1995). J Cell Biol 130: 157–167.

  • Petronilli V, Costantini P, Scorrano L, Colonna R, Passamonti S, Bernardi P . (1994). J Biol Chem 269: 16638–16642.

  • Petronilli V, Miotto G, Canton M, Brini M, Colonna R, Bernardi P et al. (1999). Biophys J 76: 725–734.

  • Petronilli V, Szabo I, Zoratti M . (1989). FEBS Lett 259: 137–143.

  • Pfeiffer DR, Gudz TI, Novgorodov SA, Erdahl WL . (1995). J Biol Chem 270: 4923–4932.

  • Piret J, Arnould T, Fuks B, Chatelain P, Remacle J, Michiels C . (2004). Mitochondrion 3: 261–278.

  • Poncet D, Boya P, Metivier D, Zamzami N, Kroemer G . (2003). Apoptosis 8: 521–530.

  • Pratt R, Vallis LM, Lim CW, Chisnall WN . (1987). Pathology 19: 162–165.

  • Precht TA, Phelps RA, Linseman DA, Butts BD, Le SS, Laessig TA et al. (2005). Cell Death Differ 12: 255–265.

  • Prevarskaya N, Skryma R, Shuba Y . (2004). Biochem Biophys Res Commun 322: 1326–1335.

  • Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC et al. (1997). Science 275: 967–969.

  • Rauen U, Petrat F, Sustmann R, de Groot H . (2004). J Hepatol 40: 607–615.

  • Ravagnan L, Marzo I, Costantini P, Susin SA, Zamzami N, Petit PX et al. (1999). Oncogene 18: 2537–2546.

  • Rempel A, Mathupala SP, Griffin CA, Hawkins AL, Pedersen PL . (1996). Cancer Res 56: 2468–2471.

  • Ricci J, Gottlieb R, Green D . (2003). J Cell Biol 160: 65–75.

  • Rostovtseva T, Tan W, Colombini M . (2005). J Bioenerg Biomembr 37: 129–142.

  • Rotem R, Heyfets A, Fingrut O, Blickstein D, Shaklai M, Flescher E . (2005). Cancer Res 65: 1984–1993.

  • Sakurai K, Katoh M, Fujimoto Y . (2001). J Biol Chem 276: 26942–26946.

  • Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ et al. (1998). EMBO J 17: 1675–1687.

  • Schempp C, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer C et al. (2002). Oncogene 21: 1242–1250.

  • Schinzel A, Takeuchi O, Huang Z, Fisher J, Zhou Z, Rubens J et al. (2005). Proc Natl Acad Sci USA 102: 12005–12010.

  • Schneider M . (2005). Sci STKE 2005: pe26.

  • Schoenfeld N, Bauer MK, Grimm S . (2004). FASEB J 18: 158–160.

  • Schubert A, Grimm S . (2004). Cancer Res 64: 85–93.

  • Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T et al. (2003). Science 300: 135–139.

  • Scorrano L, Petronilli V, Di Lisa F, Bernardi P . (1999). J Biol Chem 274: 22581–22585.

  • Shinohara Y, Ichihara J, Terada H . (1991). FEBS Lett 291: 55–57.

  • Shinohara Y, Ishida T, Hino M, Yamazaki N, Baba Y, Terada H . (2000). Eur J Biochem 267: 6067–6073.

  • Shoshan-Barmatz V, Gincel D . (2003). Cell Biochem Biophys 39: 279–292.

  • Smaili SS, Hsu YT, Sanders KM, Russell JT, Youle RJ . (2001). Cell Death Differ 8: 909–920.

  • Sourdeval M, Lemaire C, Deniaud A, Brenner C, Taysse L, Daulon S et al. Apoptosis (in press).

  • Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL . (2001). Cancer Res 61: 6669–6673.

  • Szabo I, Zoratti M . (1991). J Biol Chem 266: 3376–3379.

  • Szabo I, Zoratti M . (1992). J Bioenerg Biomembr 24: 111–117.

  • Tafani M, Minchenko D, Serroni A, Farber J . (2001). Cancer Res 61: 2459–2466.

  • Tanveer A, Virji S, Andreeva L, Totty NF, Hsuan JJ, Ward JM et al. (1996). Eur J Biochem 238: 166–172.

  • Tinhofer I, Bernhard D, Senfter M, Anether G, Loeffler M, Kroemer G et al. (2001). FASEB J, 1613–1615.

  • Townson JL, Naumov GN, Chambers AF . (2003). Curr Mol Med 3: 631–642.

  • Troyano A, Sancho P, Fernandez C, de Blas E, Bernardi P, Aller P . (2003). Cell Death Differ 10: 889–898.

  • Valentijn AJ, Gilmore AP . (2004). J Biol Chem 279: 32848–32857.

  • Valentijn AJ, Metcalfe AD, Kott J, Streuli CH, Gilmore AP . (2003). J Cell Biol 162: 599–612.

  • Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB . (1997). Cell 91: 627–637.

  • Vander Heiden MG, Thompson CB . (1999). Nat Cell Biol 1: E209–E216.

  • Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S et al. (2000). Mol Cell Biol 20: 5454–5468.

  • Vayssiere JL, Petit PX, Risler Y, Mignotte B . (1994). Proc Natl Acad Sci USA 91: 11752–11756.

  • Venturini I, Zeneroli M, Corsi L, Avallone R, Farina F, Alho H et al. (1998). Life Sci 63: 1269–1280.

  • Verrier F, Deniaud A, LeBras M, Metivier D, Kroemer G, Mignotte B et al. (2004). Oncogene 23: 8049–8064.

  • Vieira HL, Belzacq AS, Haouzi D, Bernassola F, Cohen I, Jacotot E et al. (2001). Oncogene 20: 4305–4316.

  • Vieira HL, Boya P, Cohen I, El Hamel C, Haouzi D, Druillenec S et al. (2002). Oncogene 21: 1963–1977.

  • Vieira HL, Haouzi D, El Hamel C, Jacotot E, Belzacq AS, Brenner C et al. (2000). Cell Death Differ 7: 1146–1154.

  • Waldmeier P, Feldtrauer J, Qian T, Lemasters J . (2002). Mol Pharmacol 62: 22–29.

  • Warburg O . (1956). Science 123: 309–314.

  • Weaver JGR, Tarze A, Moffat TC, Le Bras M, Deniaud A, Brenner C et al. (2005). J Clin Inves 115: 1828–1838.

  • Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ et al. (2001). Science 292: 727–730.

  • Weisinger G, Kelly-Hershkovitz E, Veenman L, Spanier I, Leschiner S, Gavish M . (2004). Biochemistry 43: 12315–12321.

  • Wondrak G, Jacobson M, Jacobson E . (2005). J Pharmacol Exp Ther 316: 805–814.

  • Yang JC, Cortopassi GA . (1998). Biochem Biophys Res Commun 250: 454–457.

  • Yasuda S, Arii S, Mori A, Isobe N, Yang W, Oe H et al. (2004). J Hepatol 40: 117–123.

  • Zaid H, Abu-Hamad S, Israelson A, Nathan I, Shoshan-Barmatz V . (2005). Cell Death Differ 12: 751–760.

  • Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G . (1998). Oncogene 16: 2265–2282.

  • Zamzami N, El Hamel C, Maisse C, Brenner C, Munoz-Pinedo C, Belzacq AS et al. (2000). Oncogene 19: 6342–6350.

  • Zamzami N, Larochette N, Kroemer G . (2005). Cell Death Differ 12 (Suppl 2): 1478–1480.

  • Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssière J-L, Petit PX et al. (1995). J Exp Med 181: 1661–1672.

  • Zoratti M, Szabo I . (1994). J Bioenerg Biomembr 26: 543–553.

  • Zoratti M, Szabo I . (1995). Biochim Biophys Acta 1241: 139–176.

  • Zoratti M, Szabo I, De Marchi U . (2005). Biochim Biophys Acta 1706: 40–52.

  • Zunino S, Storms D . (2005). Cancer Lett, Oct 12 [E-pub ahead of print].

Download references

Acknowledgements

This work was supported by grants funded by ARC, La Ligue contre le Cancer and the Ministère délégué à la Recherche et aux Nouvelles Technologies (MRNT) (Subvention Genhomme, Convention 03L297) (to CB) and the Wellcome Trust and Cancer Research UK (to SG).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to C Brenner.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Brenner, C., Grimm, S. The permeability transition pore complex in cancer cell death. Oncogene 25, 4744–4756 (2006). https://doi.org/10.1038/sj.onc.1209609

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1209609

Keywords

  • mitochondria
  • apoptosis
  • adenine nucleotide translocator
  • cyclophilin D
  • VDAC

Further reading

Search

Quick links