Table 3 Mutations in complex IV

From: Mitochondrial DNA mutations in human cancer

Region Nucleotide change Nucleotide position Type of cancer Amino-acid change References
COX I G-A 5973 Pancreatic, Prostate ALA-THR Jeronimo et al. (2001); Jones et al. (2001)
COX I G-A 6267 Pancreatic, Prostate ALA-THR Jeronimo et al. (2001); Jones et al. (2001)
COX I G-A 5913 Prostate ASP-ASN Jeronimo et al. (2001)
COX I G-A 6264 Colon GLY-Stop Polyak et al. (1998)
COX I A-G 5935 Prostate ASN-SER Jeronimo et al. (2001)
COX I G-A 5949 Prostate GLY-Stop Jeronimo et al. (2001)
COX I G-A 6081 Prostate ALA-THR Jeronimo et al. (2001)
COX I G-A 6150 Prostate VAL -ILE Jeronimo et al. (2001)
COX I T-C 6124 Prostate MET-THR Jeronimo et al. (2001)
COX I T-C 6253 Prostate MET-THR Jeronimo et al. (2001)
COX I G-A 6261 Prostate ALA-THR Jeronimo et al. (2001)
COX I G-A 6285 Prostate VAL-ILE Jeronimo et al. (2001)
COX I C-T 6340 Prostate THR-ILE Jeronimo et al. (2001)
COX I G-A 6480 Prostate VAL-ILE Jeronimo et al. (2001)
COX I A-G 6663 Prostate ILE-VAL Jeronimo et al. (2001)
COX I G-T 6924 Prostate ALA-SER Jeronimo et al. (2001)
COX I G-A 7041 Prostate VAL-ILE Jeronimo et al. (2001)
COX I T-C 7080 Prostate PHE-LEU Jeronimo et al. (2001)
COX I A-G 7083 Prostate ILE-VAL Jeronimo et al. (2001)
COX I A-G 7158 Prostate ILE-VAL Jeronimo et al. (2001)
COX I A-C 7305 Prostate MET-LEU Jeronimo et al. (2001)
COX II G-A 8009 Colon VAL-MET Polyak et al. (1998)
COX II G-T 7986 Pancreatic ARG-GLN Jones et al. (2001)
COX II Deletion 7631–8203 Thyroid   Maximo et al. (2002)
COX II Deletion 7627–8195 Thyroid   Maximo et al. (2002)
COX II T-C 7785 Thyroid ILE-THR Maximo et al. (2002)
COX II G-A 7775 Thyroid VAL-ILE Maximo et al. (2002)
COX III G-A 9949 Colon VAL-ILE Polyak et al. (1998)
COX III G-A 9804 Pancreatic ALA-THR Jones et al. (2001)
COX III G-A 9948 Thyroid VAL-ILE Abu-Amero et al. (2005)
COX III G-T 9477 Thyroid VAL-PHE Maximo et al. (2002)
COX III G-A 9477 Thyroid VAL-ILE Maximo et al. (2002)
COX III G-A 9655 Thyroid SER-ASN Maximo et al. (2002)
COX III C-T 9691 Thyroid ALA-VAL Maximo et al. (2002)