Figure 6 | Oncogene

Figure 6

From: Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB

Figure 6

Expression of cyclooxygenase-2 (Cox-2) in esophageal cancers. (a) Cyclooxygenase-2 immunostaining in representative sections of normal squamous mucosa (1), squamous dysplasia (2), in situ squamous cell carcinoma (SCC) (3), Barrett's mucosa (4, 5) and adenocarcinoma (ADC) (6). Bars: 10 μ M. Note the absence of staining in normal squamous mucosa (1) and patchy staining in Barrett's mucosa (5). (b) Correlation between Cox-2 immunopositivity in cancer and TP53 mutation status. Histograms show, for SCC and ADC, the proportion of tumors with or without TP53 mutation that express Cox-2 in over 20% of cancer cells. p: Fisher's exact test for Cox-2 expression in ADC, mutant vs wild-type TP53.