Table 2 Hypermethylation of the POU2F3 promoter in cervical cancer cell lines and cervical tissue

From: Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer

Samples Tumor classification Methylation
   Positive Negative Frequency of methylation (%)
Cervical cancers   18 28 18/46 (39%)
  Histology a    
   Adenocarcinoma 1 4  
   Adenosquamous 4 5  
   Squamous 13 19  
  HPV type a    
   HPV16 7 11  
   HPV18 4 9  
   Other 2 5  
   Multiple 5 3  
  Stage a    
   I 16 25  
   II 2 3  
  Lymph node metastasis a    
   Positive 3 6  
   Negative 10 17  
   ND 5 5  
CC cell lines   6 5 6/11 (54.5%)
Normal cervical epithelium   0 7 0/7 (0%)
  1. ND: not determined.
  2. aThe methylation of POU2F3 CpG sites did not correlate statistically with clinicopathological features such as tumor histology, HPV type, stage and lymph node metastasis (P>0.05).