Abstract
The t(3;14)(q27;q32) is the most common translocation involving BCL6 in B-cell lymphoma. Although this translocation was predominantly associated with diffuse large B-cell lymphoma (DLBCL), recent studies have shown that it can also be found in follicular lymphomas (FL), often associated with a large cell component. To further investigate the relationship that might exist between this translocation and the phenotype of the tumors, we studied 34 lymphomas with a t(3;14)(q27;q32). Twenty cases were DLBCL, 14 FL and most cases, regardless of histology, were negative for the expression of CD10 (26/32, 81%). We identified the IGH switch region involved in the translocation for 32 cases. Our data indicate that in DLBCL most breakpoints involve the switch μ (17/19; 89%), whereas in FL most involve a switch γ (9/13; 70%) (P=0.0016, Fisher's exact test). This correlation between the histology and the structure of the translocated allele suggests that the lymphomas with Sμ and Sγ translocations may originate from different cells, or that the substituted regulatory regions that come to deregulate BCL6 may affect the presentation of the disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Akasaka H, Akasaka T, Kurata M, Ueda C, Shimizu A, Uchiyama T et al. (2000a). Cancer Res 60: 2335–2341.
Akasaka T, Lossos IS, Levy R . (2003). Blood 102: 1443–1448.
Akasaka T, Ueda C, Kurata M, Akasaka H, Yamabe H, Uchiyama T et al. (2000b). Blood 96: 2907–2909.
Barrans SL, O'Connor SJ, Evans PA, Davies FE, Owen RG, Haynes AP et al. (2002). Br J Haematol 117: 322–332.
Bastard C, Deweindt C, Kerckaert JP, Lenormand B, Rossi A, Pezzella F et al. (1994). Blood 83: 2423–2427.
Bosga-Bouwer AG, van Imhoff GW, Boonstra R, van d V, Haralambieva E, van den BA et al. (2003). Blood 101: 1149–1154.
Butler MP, Iida S, Capello D, Rossi D, Rao PH, Nallasivam P et al. (2002). Cancer Res 62: 4089–4094.
Falini B, Fizzotti M, Pucciarini A, Bigerna B, Marafioti T, Gambacorta M et al. (2000). Blood 95: 2084–2092.
Horsman DE, McNeil BK, Anderson M, Shenkier T, Gascoyne RD . (1995). Br J Haematol 89: 569–575.
Horsman DE, Okamoto I, Ludkovski O, Le N, Harder L, Gesk S et al. (2003). Br J Haematol 120: 424–433.
Islam KB, Baskin B, Christensson B, Hammarstrom L, Smith CI . (1994). Clin Exp Immunol 95: 3–9.
Jaffe ES, Harris NL, Stein H, Vardiman J . (2001). Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon, 2001.
Jardin F, Bastard C, Contentin N, Parmentier F, Picquenot JM, Tilly H et al. (2003). Blood 102: 1872–1876.
Jardin F, Buchonnet G, Parmentier F, Contentin N, Lepretre S, Lenain P et al. (2002a). Leukemia 16: 2318–2325.
Jardin F, Gaulard P, Buchonnet G, Contentin N, Lepretre S, Lenain P et al. (2002b). Leukemia 16: 2309–2317.
Katzenberger T, Ott G, Klein T, Kalla J, Muller-Hermelink HK, Ott MM . (2004). Am J Pathol 165: 481–490.
Kawakami K, Miyanishi S, Sonoki T, Nakamura S, Nomura KN, Toniwaki M et al. (2004). Int J Hematol 79: 474–479.
Kawamata N, Nakamura Y, Miki T, Sato E, Isobe Y, Furusawa S et al. (1998). Br J Haematol 100: 484–489.
Lo CF, Ye BH, Lista F, Corradini P, Offit K, Knowles DM et al. (1994). Blood 83: 1757–1759.
Lossos IS, Akasaka T, Martinez-Climent JA, Siebert R, Levy R . (2003). Leukemia 17: 1390–1397.
Lossos IS, Jones CD, Warnke R, Natkunam Y, Kaizer H, Zehnder JL et al. (2001). Blood 98: 945–951.
Mertens F, Johansson M, Mitelman F . (1995). Cancer Genet Cytogenet 83: 176–177.
Nagaoka H, Muramatsu M, Yamamura N, Kinoshita K, Honjo T . (2002). J Exp Med 195: 529–534.
Neri A, Barriga F, Knowled DM, Magrath IT, Dalla-Favera R . (1988). Proc Natl Acad Sci USA 85: 2748–2752.
Offit K, Lo CF, Louie DC, Parsa NZ, Leung D, Portlock C et al. (1994). N Engl J Med 331: 74–80.
Otsuki T, Yano T, Clark HM, Bastard C, Kerckaert JP, Jaffe ES et al. (1995). Blood 85: 2877–2884.
Ott G, Katzenberger T, Lohr A, Kindelberger S, Rudiger T, Wilhelm M et al. (2002). Blood 99: 3806–3812.
Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF et al. (2004). Nat Med 10: 1329–1335.
Schaffer A, Cerutti A, Shah S, Zan H, Casali P . (1999). J Immunol 162: 5327–5336.
Stavnezer-Nordgren J, Sirlin S . (1986). EMBO J 5: 95–102.
Ueda C, Akasaka T, Ohno H . (2002a). Leuk Lymphoma 43: 1375–1381.
Ueda C, Uchiyama T, Ohno H . (2002b). Blood 99: 2624–2625.
Willis TG, Dyer MJ . (2000). Blood 96: 808–822.
Wlodarska I, Mecucci C, Stul M, Michaux L, Pittaluga S, Hernandez JM et al. (1995). Genes Chromosomes Cancer 14: 1–7.
Ye BH, Chaganti S, Chang CC, Niu H, Corradini P, Chaganti RS et al. (1995). EMBO J 14: 6209–6217.
Acknowledgements
This work was supported by grants from the Comité de l'Eure de la Ligue Contre le Cancer.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ruminy, P., Jardin, F., Picquenot, J. et al. Two patterns of chromosomal breakpoint locations on the immunoglobulin heavy-chain locus in B-cell lymphomas with t(3;14)(q27;q32): relevance to histology. Oncogene 25, 4947–4954 (2006). https://doi.org/10.1038/sj.onc.1209512
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1209512