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Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma

Oncogene volume 25, pages 4257–4266 (2006)Cite this article

Abstract

Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in multiple myeloma (MM). The encouraging results of preclinical and clinical trials in which MM has been treated by targeting the tumor microenvironment are also discussed.

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Acknowledgements

This work was supported by Associazione Italiana per la Ricerca sul Cancro (AIRC, National and Regional Funds), Milan, Ministry for Education, the Universities and Research (Project CARSO no. 72/2) and Ministry for Health – Regione Puglia (Grant BS2 and ‘Convenzione n. 131/Ricerca Finalizzata IRCCS’), Rome, and Fondazione Italiana per la Lotta al Neuroblastoma, Genoa, Italy.

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  1. Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

    D Ribatti & B Nico

  2. Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy

    A Vacca

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Ribatti, D., Nico, B. & Vacca, A. Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma. Oncogene 25, 4257–4266 (2006). https://doi.org/10.1038/sj.onc.1209456

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