Figure 5 | Oncogene

Figure 5

From: Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis

Figure 5

Box plot analysis illustrating loss of SFRP1 mRNA expression in relation to SFRP1 promoter methylation. Factor of SFRP1 mRNA downregulation relative to the normal breast standard (a normal breast tissue sample containing approximately 40% of epithelial cells) is shown on the Y axis (fold change N/T). Unmethylated breast tumours exhibit a very moderate SFRP1 downregulation, very weakly methylated tumours exhibit a somewhat stronger downregulation, however, only clearly methylated breast tumours exhibit strong SFRP1 downregulation. This correlation between SFRP1 methylation and SFRP1 mRNA downregulation is highly significant (P-values of the Mann–Whitney U-test are given for the two comparisons). Horizontal lines: group medians; boxes: 25–75% quartiles, range, peak and minimum.

Back to article page