Table 2 Genotype frequencies of XRCC1 polymorphisms among patients and controls, and their association with the risk of lung cancer

From: A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer

Genotype (dbSNP) Patients (n=1024) Controls (n=1118) OR (95% CI)a
  No. (%) No. (%)  
77T>C (rs3213245)
 TT 783 76.5 924 82.6 1.00 (reference)
 TC 223 21.8 182 16.3 1.44 (1.16–1.80)b
 CC 18 1.7 12 1.1 1.87 (0.87–4.01)
 TC+CC 241 23.5 194 17.4 1.46 (1.18–1.82)c
194 Arg>Trp (rs1799782)
 Arg/Arg 524 51.2 572 51.2 1.00 (reference)
 Arg/Trp 409 39.9 459 41.1 0.98 (0.82–1.18)
 Trp/Trp 91 8.9 87 7.7 1.11 (0.80–1.54)
 Arg/Trp+Trp/Trp 500 48.8 546 48.8 1.00 (0.84–1.20)
280 Arg>His (rs25489)
 Arg/Arg 848 82.8 904 80.9 1.00 (reference)
 Arg/His 169 16.5 204 18.2 0.90 (0.71–1.13)
 His/His 7 0.7 10 0.9 0.72 (0.27–1.93)
 Arg/His+His/His 176 17.2 214 19.1 0.89 (0.71–1.12)
399 Arg>Gln (rs25487)
 Arg/Arg 566 55.3 585 52.3 1.00 (reference)
 Arg/Gln 376 36.7 432 38.6 0.89 (0.74–1.07)
 Gln/Gln 82 8.0 101 9.1 0.86 (0.62–1.18)
 Arg/Gln+Gln/Gln 458 44.7 533 47.7 0.88 (0.74–1.05)
  1. aData were calculated by unconditional logistic regression and adjusted for sex, age, smoking status, and other genotype where it was appropriate.
  2. bP=0.002.
  3. cP=0.001.