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Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis

Oncogene volume 24, pages 5931–5937 (2005)Cite this article

Abstract

I briefly review the discovery and characterization of the first human retrovirus, human T-cell leukemia virus type 1, focusing on contributions from Japanese researchers. The unique regulatory mechanisms for the viral regulation with Tax and Rex, etiology of ATL and possible leukemogenic mechanism with Tax are also discussed briefly.

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References

  • Barmak K, Harhaj E, Grant C, Alefantis T and Wigdahl B . (2003). Virology, 308, 1–12.

  • Copeland KF, Haaksma AG, Goudsmit J, Krammer PH and Heeney JL . (1994). AIDS Res. Hum. Retroviruses., 10, 1259–1268.

  • Fujisawa J, Seiki M, Kiyokawa T and Yoshida M . (1985). Proc. Natl. Acad. Sci. USA, 82, 2277–2281.

  • Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A and de The G . (1985). Lancet, 2, 407–410.

  • Hidaka M, Inoue J, Yoshida M and Seiki M . (1988). EMBO J., 7, 519–523.

  • Hino S, Katamine S, Kawase K, Miyamoto T, Doi H, Tsuji Y and Yamabe T . (1994). Leukemia, (Suppl 1), S68–S70.

  • Hinuma Y, Komoda H, Chosa T, Kondo T, Kohakura M, Takenaka T, Kikuchi M, Ichimaru M, Yunoki K, Sato I, Matsuo R, Takiuchi Y, Uchino H and Hanaoka M . (1981a). Int. J. Cancer., 15, 631–635.

  • Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S and Miyoshi I . (1981b). Proc. Natl. Acad. Sci. USA, 78, 6476–6480.

  • Hirai H, Suzuki T, Fujisawa J, Inoue J and Yoshida M . (1994). Proc. Natl. Acad. Sci. USA, 91, 3584–3588.

  • Inoue J, Seiki M, Taniguchi T, Tsuru S and Yoshida M . (1986). EMBO J., 5, 2883–2888.

  • Isobe M, Sadamori N, Russo G, Shimizu S, Yamamori S, Itoyama T, Yamada Y, Ikeda S, Ichimaru M and Kagan J . (1990). Cancer Res., 50, 6171–6175.

  • Jeang KT, Widen SG, Semmes OJt and Wilson SH . (1990). Science, 247, 1082–1084.

  • Jin DY, Spencer F and Jeang KT . (1998). Cell, 93, 81–91.

  • Kinoshita T, Shimoyama M, Tobinai K, Ito M, Ito S, Ikeda S, Tajima K, Shimotohno K and Sugimura T . (1989). Proc. Natl. Acad. Sci. USA, 86, 5620–5624.

  • Kiyokawa T, Seiki M, Imagawa K, Shimizu F and Yoshida M . (1984). Gann, 75, 747–751.

  • Kiyokawa T, Seiki M, Iwashita S, Imagawa K, Shimizu F and Yoshida M . (1985). Proc. Natl. Acad. Sci. USA, 82, 8359–8363.

  • Koralnik IJ, Gessain A, Klotman ME, LoMonico A, Berneman ZN and Franchini G . (1992). Proc. Natl. Acad. Sci. USA, 89, 8813–8817.

  • Miyake H, Suzuki T, Hirai H and Yoshida M . (1999). Virology, 253, 155–161.

  • Miyoshi I, Kubonishi I, Sumida M, Hiraki S, Tsubota T, Kimura I, Miyamoto K and Sato J . (1980). Gann, 71, 155–156.

  • Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K and Hinuma Y . (1981). Nature, 294, 770–771.

  • Nerenberg M, Hinrichs SH, Reynolds RK, Khoury G and Jay G . (1987). Science, 237, 1324–1329.

  • Okochi K, Sato H and Hinuma Y . (1984). Vox Sang., 46, 245–253.

  • Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M and Tara M . (1986). Lancet, 1, 1031–1032.

  • Poeisz BJ, Ruscetti RW, Gazdar AF, Bunn PA, Minna JD and Gallo RC . (1980). Proc. Natl. Acad. Sci. USA, 77, 7415–7419.

  • Pozzatti R, Vogel J and Jay G . (1990). Mol. Cell. Biol., 10, 413–417.

  • Seiki M, Eddy R, Shows TB and Yoshida M . (1984). Nature, 309, 640–642.

  • Seiki M, Hattori S, Hirayama Y and Yoshida M . (1983). Proc. Natl. Acad. Sci. USA, 80, 3618–3622.

  • Seiki M, Hattori S and Yoshida M . (1982. Proc. Natl. Acad. Sci. USA, 79, 6899–6902.

  • Seiki M, Hikikoshi A, Taniguchi T and Yoshida M . (1985). Science, 228, 1532–1534.

  • Seiki M, Inoue J, Hidaka M and Yoshida M . (1988). Proc. Natl. Acad. Sci. USA, 85, 7124–7128.

  • Shimoyama M, Kagami Y, Shimotohno K, Miwa M, Minato K, Tobinai K, Suemasu K and Sugimura T . (1986). Proc. Natl. Acad. Sci. USA, 83, 4524–4528.

  • Sodroski JG, Rosen CA and Haseltine WA . (1984). Science, 225, 381–385.

  • Sugiyama H, Doi H, Yamaguchi K, Tsuji Y, Miyamoto T and Hino S . (1986). J. Med. Virol., 20, 253–260.

  • Suzuki T, Kitao S, Matsushime H and Yoshida M . (1996). EMBO J., 15, 1607–1614.

  • Suzuki T, Ohsugi Y, Uchida-Toita M, Akiyama M and Yoshida M . (1999). Oncogene, 18, 5967–5972.

  • Suzuki T, Uchida-Toita M, Andoh T and Yoshida M . (2000). Virology, 270, 291–298.

  • Tajima K, Tominaga S and Suchi T . (1986). Hematol. Oncol., 4, 31–44.

  • Tajima K . (1990). Int. J. Cancer, 45, 237–243.

  • Tanaka A, Takahashi C, Yamaoka S, Nosaka T, Maki M and Hatanaka M . (1990). Proc. Natl. Acad. Sci. USA, 87, 1071–1075.

  • Teich N, Wyke J, Mak T, Bernstein A and Hardy W . (1985). RNA tumor viruses Weis R, Teich N, Varmus H and Coffin J (eds). Cold Spring Harbor Laboratory, pp 785–998.

    Google Scholar 

  • Uchiyama T, Hori T, Tsudo M, Wano Y, Umadome H, Tamori S, Yodoi J, Maeda M, Sawami H and Uchino H . (1985). J. Cli. Invest., 76, 446–453.

  • Uchiyama T, Yodoi J, Sagawa K, Takatsuki K and Uchino H . (1977). Blood, 50, 481–492.

  • Watanabe T, Seiki M and Yoshida M . (1984). Virology, 133, 238–241.

  • Yoshida M, Miyoshi I and Hinuma Y . (1982). Proc. Natl. Acad. Sci. USA, 79, 2031–2035.

  • Yoshida M, Seiki M, Yamaguchi K and Takatsuki K . (1984). Proc. Natl. Acad. Sci. USA, 81, 2534–2537.

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  1. Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., 3 Ohkubo, Tsukuba, 300-2611, Ibaraki, Japan

    Mitsuaki Yoshida

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  1. Mitsuaki Yoshida
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Correspondence to Mitsuaki Yoshida.

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Yoshida, M. Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis. Oncogene 24, 5931–5937 (2005). https://doi.org/10.1038/sj.onc.1208981

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