Abstract
The human T-cell leukemia/lymphoma virus (HTLV) genome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at its 3′ end originally designated pX. To date, we know that this region encodes two essential transcriptional and post-transcriptional positive regulators of viral expression, the Tax and Rex proteins, respectively (reviewed elsewhere in this issue). Here, we will review current knowledge of the functions of three additional proteins encoded in the pX region, p12I, p13II, and p30II.
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Acknowledgements
We thank DM D'Agostino and MD Lairmore for discussions and sharing unpublished data, and Steven J Snodgrass for editorial assistance. V Ciminale's research was supported by grants from the National Institutes of Health-Fogarty International Center, the Ministero dell'Istruzione, dell'Università e della Ricerca, the Associazione and Fondazione Italiana per la Ricerca sul Cancro, and the Istituto Superiore di Sanità AIDS Program.
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Nicot, C., Harrod, R., Ciminale, V. et al. Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions. Oncogene 24, 6026–6034 (2005). https://doi.org/10.1038/sj.onc.1208977
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DOI: https://doi.org/10.1038/sj.onc.1208977
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