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Preface to 25 years of HTLV-1 and ATL research

Oncogene volume 24, page 5925 (2005)Cite this article

In 1980, Poiesz et al. (1980) reported for the first time a link between a retrovirus and a human cancer in a patient with cutaneous T-cell lymphoma in the United States. Several years earlier, a clinical entity called adult T-cell leukemia (ATL) was described in Japan by Takatsuki and others (Uchiyama et al., 1977). Takatsuki and Gallo have recently reviewed elsewhere the original events that led to the findings of ATL (Takatsuki, 2005) and HTLV-1 (human T-cell leukemia virus type 1) (Gallo, 2005). Contemporaneous research in those early days also provided for the isolation of a retrovirus in Japan named ATLV by Hinuma et al. (1981) and Yoshida et al. (1982). As ATLV and the virus isolated by Poiesz et al. were found to be identical, a single name, HTLV-1, was adopted.

We are privileged at the quarter century mark after the discovery of HTLV-1 to organize an Oncogene Review issue dedicated to summarizing extant progress in HTLV-1/ATL research. In setting up this issue, we called upon the expertise of a diverse group of colleagues from Japan, Europe, South America, and the United States to review the history, the molecular biology and immunology, the current state of clinical therapy, and the global epidemiology of HTLV-1/ATL. We note that expertise in as well as contributions to these various research areas in HTLV-1 are not limited to those who have generously agreed to write articles; and we regret that format and page limitations prevented us from soliciting the efforts of many other friends and colleagues.

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References

  • Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD and Gallo RC . (1980). Proc. Natl. Acad. Sci. USA, 77, 7415–7419.

  • Uchiyama T, Yodoi J, Sagawa K, Takatsuki K and Uchino H . (1977). Blood, 50, 481–492.

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Authors and Affiliations

  1. Banyu Tsukuba Research Institute, Tsukuba, Japan

    Mitsuaki Yoshida

  2. Molecular Virology Section, LMM, NIAID, NIH, Bethesda, MD, USA

    Kuan-Teh Jeang

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  1. Mitsuaki Yoshida
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  2. Kuan-Teh Jeang
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Yoshida, M., Jeang, KT. Preface to 25 years of HTLV-1 and ATL research. Oncogene 24, 5925 (2005). https://doi.org/10.1038/sj.onc.1208967

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