Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

β-Catenin regulates the expression of tenascin-C in human colorectal tumors


Tenascin-C (TN-C) is a component of the extracellular matrix (ECM). It is expressed during development and re-expressed in many types of cancers, where it is involved in the modulation of adhesion and proliferation. TN-C expression is especially high at sites of epithelial mesenchymal transition (EMT), which are found frequently at the invasion front of well-differentiated human colorectal adenocarcinomas. Tumor cells in this compartment are characterized by a strong nuclear expression of the oncogenic transcription factor β-catenin. Here, we demonstrate that TN-C is a β-catenin target gene in human colorectal tumors. Thus, by far the most common mutations in colorectal tumors, found in the Wnt-signaling pathway and leading to the stabilizing of β-catenin, might influence invasion by altering adhesive properties and EMT of tumor cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1
Figure 2
Figure 3
Figure 4

Accession codes




  • Barker N, Huls G, Korinek V and Clevers H . (1999). Am. J. Pathol., 154, 29–35.

  • Barker N, Hurlstone A, Musisi H, Miles A, Bienz M and Clevers H . (2001). EMBO J., 20, 4935–4943.

  • Ben-Ze’ev A and Geiger B . (1998). Curr. Opin. Cell Biol., 10, 629–639.

  • Bienz M and Clevers H . (2000). Cell, 103, 311–320.

  • Brabletz T, Jung A, Hermann K, Gunther K, Hohenberger W and Kirchner T . (1998). Pathol. Res. Pract., 194, 701–704.

  • Brabletz T, Jung A and Kirchner T . (2002). Virchows. Arch., 441, 1–11.

  • Brabletz T, Jung A, Reu S, Porzner M, Hlubek F, Kunz-Schughart LA, Knuechel R and Kirchner T . (2001). Proc. Natl. Acad. Sci. USA, 98, 10356–10361.

  • Brembeck FH, Schwarz-Romond T, Bakkers J, Wilhelm S, Hammerschmidt M and Birchmeier W . (2004). Genes Dev., 18, 2225–2230.

  • Chiquet-Ehrismann R and Chiquet M . (2003). J. Pathol., 200, 488–499.

  • Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P and Ben-Ze’ev A . (2003). J. Cell Biol., 163, 847–857.

  • Hanamura N, Yoshida T, Matsumoto E, Kawarada Y and Sakakura T . (1997). Int. J. Cancer, 73, 10–15.

  • He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B and Kinzler KW . (1998). Science, 281, 1509–1512.

  • Hiendlmeyer E, Regus S, Wassermann S, Hlubek F, Haynl A, Dimmler A, Koch C, Knoll C, van Beest M, Reuning U, Brabletz T, Kirchner T and Jung A . (2004). Cancer Res., 64, 1209–1214.

  • Jones PL and Jones FS . (2000). Matrix Biol., 19, 581–596.

  • Jung A, Schrauder M, Oswald U, Knoll C, Sellberg P, Palmqvist R, Niedobitek G, Brabletz T and Kirchner T . (2001). Am. J. Pathol., 159, 1613–1617.

  • Kirchner T and Brabletz T . (2000). Am. J. Pathol., 157, 1113–1121.

  • Kodjabachian L, Dawid IB and Toyama R . (1999). Dev. Biol., 213, 231–245.

  • Rosin-Arbesfeld R, Cliffe A, Brabletz T and Bienz M . (2003). EMBO J., 22, 1101–1113.

  • Rowan AJ, Lamlum H, Ilyas M, Wheeler J, Straub J, Papadopoulou A, Bicknell D, Bodmer WF and Tomlinson IP . (2000). Proc. Natl. Acad. Sci. USA, 97, 3352–3357.

  • Shirasaki F, Makhluf HA, LeRoy C, Watson DK and Trojanowska M . (1999). Oncogene, 18, 7755–7764.

  • Tetsu O and McCormick F . (1999). Nature, 398, 422–426.

  • Verma UN, Surabhi RM, Schmaltieg A, Becerra C and Gaynor RB . (2003). Clin. Cancer Res., 9, 1291–1300.

Download references


This work was supported by the Wilhelm Sander-Stiftung (Az.: 1999.065.2). We thank Professor Amann for kindly providing her digital photosystem.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Andreas Jung.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Beiter, K., Hiendlmeyer, E., Brabletz, T. et al. β-Catenin regulates the expression of tenascin-C in human colorectal tumors. Oncogene 24, 8200–8204 (2005).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • β-catenin
  • tenascin-C
  • Wnt signalling
  • colorectal cancer

This article is cited by


Quick links