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The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair

Oncogene volume 24, pages 5269–5277 (2005)Cite this article

Abstract

The fibroblast growth factor-binding protein (FGF-BP) binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis. In this study, we identified novel binding partners of FGF-BP, and we provide evidence for a role of this protein in epithelial repair processes. We show that expression of FGF-BP increases after injury to murine and human skin, in particular in keratinocytes. This upregulation is most likely achieved by major keratinocyte mitogens present at the wound site. Most importantly, we demonstrate that FGF-BP interacts with FGF-7, FGF-10, and with the recently identified FGF-22, and enhances the activity of low concentrations of ligand. Due to the important functions of FGF-7 and FGF-10 for repair of injured epithelia, our findings suggest that upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair.

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Acknowledgements

This work was supported by the Swiss National Science Foundation (grant No. 31-61358.00 to SW), the German Ministry for Education and Research (BMBF to SW and AG), and the ETH Zürich (to SW). We thank Christiane Born-Berclaz for excellent technical assistance, Dr Richard Grose and Tobias Beyer for the nontagged and HA-tagged FGF-22 cDNAs, Dr Clive Dickson for helpful suggestions, and Dr Jeffrey Rubin, NIH, Bethesda, for critically reading the manuscript.

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  1. Department of Biology, Institute of Cell Biology, ETH Zürich, Hönggerberg, CH-8093, Zürich, Switzerland

    Hans-Dietmar Beer, Gisela Niklaus, Christine Munding & Sabine Werner

  2. Switch Biotech AG, Floriansbogen 2-4, Neuried, D-82061, Germany

    Michaela Bittner, Nicole Max & Andreas Goppelt

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  1. Hans-Dietmar Beer
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Correspondence to Sabine Werner.

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Beer, HD., Bittner, M., Niklaus, G. et al. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene 24, 5269–5277 (2005). https://doi.org/10.1038/sj.onc.1208560

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