Table 1 Summary of PIK3CA mutations in the cancers analysed

From: PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas

PIK3CA mutationsa Type of cancer b
Exon Nucleotide change (predicted amino-acid change) Breast cancer (intraductal carcinoma) Gastric cancer (early gastric cancer) Hepatocellular carcinoma (dysplastic nodule) Lung cancer Acute leukemia Total
9 G1624A (E542K) 2 0 0 1 0 3
9 G1633A (E545K) 2 3 0 1 0 6
9 A1634C (E545A) 0 0 11 0 1 12
9 A1637G (Q546R) 0 1 0 0 0 1
20 C3032T (P1011S) 0 1 0 0 0 1
20 A3062G (Y1021C) 0 2 0 0 0 2
20 A3101G (E1035G) 0 0 1 0 0 1
20 T3128C (M1043T) 0 1 0 0 0 1
20 A3140G (H1047R) 21 (2) 4 (1) 1 1 0 27
20 A3140T (H1047L) 1 0 0 0 0 1
20 3204_3205insA 0 1 13 0 0 14
No. of mutations 26 13 (1) 26 3 1 69
No. of cancers with mutations 25 12 26 3 1 67
No. of samples screened 93 185 73 229 88 668
Percent of cancers with mutations 26.9% 6.5% 35.6% 1.3% 1.1% 10.0%
  1. aNumbering of cDNA of PIK3CA was done with respect to the ATG start codon.
  2. bNumbers of mutations observed in the indicated tumors