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The cancer epidemiology of radiation

Oncogene volume 23, pages 6404–6428 (2004)Cite this article

Abstract

Ionizing radiation has been the subject of intense epidemiological investigation. Studies have demonstrated that exposure to moderate-to-high levels can cause most forms of cancer, leukaemia and cancers of the breast, lung and thyroid being particularly sensitive to induction by radiation, especially at young ages at exposure. Predominant among these studies is the Life Span Study of the cohort of survivors of the atomic bombings of Japan in 1945, but substantial evidence is derived from groups exposed for medical reasons, occupationally or environmentally. Notable among these other groups are underground hard rock miners who inhaled radioactive radon gas and its decay products, large numbers of patients irradiated therapeutically and workers who received high doses in the nuclear weapons programme of the former USSR. The degree of carcinogenic risk arising from low levels of exposure is more contentious, but the available evidence points to an increased risk that is approximately proportional to the dose received. Epidemiological investigations of nonionizing radiation have established ultraviolet radiation as a cause of skin cancer. However, the evidence for a carcinogenic effect of other forms of nonionizing radiation, such as those associated with mobile telephones or electricity transmission lines, is not convincing, although the possibility of a link between childhood leukaemia and extremely low-frequency electromagnetic fields cannot be dismissed entirely.

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References

  • Adams EE and Brues AM . (1980). J. Occup. Med., 22, 583–587.

  • Advisory Group on Ionising Radiation (AGIR) (2000). Documents of the NRPB Vol. 11(1) National Radiological Protection Board: Chilton.

  • Advisory Group on Non-ionising Radiation (AGNIR) (1992). Documents of the NRPB Vol. 3(1). National Radiological Protection Board: Chilton.

  • Advisory Group on Non-ionising Radiation (AGNIR) (1994). Documents of the NRPB Vol. 5(2) National Radiological Protection Board: Chilton, pp. 77–81.

  • Advisory Group on Non-ionising Radiation (AGNIR) (2001). Documents of the NRPB Vol. 12(1) National Radiological Protection Board: Chilton.

  • Advisory Group on Non-ionising Radiation (AGNIR) (2002). Documents of the NRPB Vol. 13(1) National Radiological Protection Board: Chilton, pp. 1–282.

  • Advisory Group on Non-ionising Radiation (AGNIR) (2003). Documents of the NRPB Vol. 14(2) National Radiological Protection Board: Chilton, pp. 1–177.

  • Ahlbom A, Day N, Feychting M, Roman E, Skinner J, Dockerty J, Linet M, McBride M, Michaelis J, Olsen JH, Tynes T and Verkasalo PK . (2000). Br. J. Cancer, 83, 692–698.

  • Ahlbom IC, Cardis E, Green A, Linet M, Savitz D, Swerdlow A and ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology. (2001). Environ. Health Perspect., 109 (Suppl 6), 911–933.

  • Astakhova LN, Anspaugh LR, Beebe GW, Bouville A, Drozdovitch VV, Garber V, Gavrilin YI, Khrouch VT, Kuvshinnikov AV, Kuzmenkov YN, Minenko VP, Moschik KV, Nalivko AS, Robbins J, Shemiakina EV, Shinkarev S, Tochitskaya SI and Waclawiw MA . (1998). Radiat. Res., 150, 349–356.

  • Atkinson WD, Bull RK, Marshall M, Morgan GR, Newton D and Salmon L . (1994). J. Radiol. Prot., 14, 109–114.

  • Atkinson WD, Law DV and Bromley KJ . (2002). Proceedings of the 4th International Conference on Health Effects of Low-level Radiation, September 2002, Oxford. Thomas Telford: London, Paper 08.

    Google Scholar 

  • Band PR, Le ND, Fang R, Deschamps M, Coldman AJ, Gallagher RP and Moody J . (1996). Am. J. Epidemiol., 143, 137–143.

  • Bataille V, Winnett A, Sasieni P, Newton Bishop JA and Cuzick J . (2004). Eur. J. Cancer, 40, 429–435.

  • Baverstock KF and Papworth DG . (1989). Risks from Radium and Thorotrast. BIR Report 21. Taylor DM, Mays CW, Gerber GB and Thomas RG (eds). British Institute of Radiology: London, pp. 72–76.

    Google Scholar 

  • Beral V and Darby SC . (2001). The Health Hazards of Depleted Uranium Munitions, Part I. The Royal Society: London, pp. 75–80.

    Google Scholar 

  • Beral V, Inskip H, Fraser P, Booth M, Coleman D and Rose G . (1985). BMJ, 291, 440–447.

  • Berrington A, Darby SC, Weiss HA and Doll R . (2001). Br. J. Radiol., 74, 507–519.

  • Bithell JF and Stewart AM . (1975). Br. J. Cancer, 31, 271–287.

  • Blettner M, Zeeb H, Auvinen A, Ballard TJ, Caldora M, Eliasch H, Gundestrup M, Haldorsen T, Hammar N, Hammer GP, Irvine D, Langner I, Paridou A, Pukkala E, Rafnsson V, Storm H, Tulinius H, Tveten U and Tzonou A . (2003). Int. J. Cancer, 106, 946–952.

  • Boice Jr JD . (2002). J. Radiol. Prot., 22, 102–104.

  • Boice Jr JD, Blettner M and Auvinen A . (2000). Health Phys., 79, 576–584.

  • Boice Jr JD, Blettner M, Kleinerman RA, Stovall M, Moloney WC, Engholm G, Austin DF, Bosch A, Cookfair DL, Krementz ET, Latourette HB, Pelers LJ, Schulz MD, Lundell M, Pettersson F, Storm HH, Bell CMJ, Coleman MP, Fraser P, Palmer M, Prior P, Choi NW, Hislop TG, Koch M, Robb D, Robson D, Spenglar RF, von Fournier D, Frischkorn R, LochmĂĽller H, Pompe-Kirn V, Rimpela A, Kjørstad K, Pejovic MH, Sigurdeson K, Plaani P, Kucera H and Hutchison GB . (1987). J. Natl. Cancer Inst., 79, 1295–1311.

  • Boice Jr JD, Day NE, Andersen A, Brinton LA, Brown R, Choi NW, Clarke EA, Coleman MP, Curtis RE, Flannery JT, Hakama M, Hakulinen T, Howe GR, Jensen OM, Kleinerman RA, Magnin D, Magnus K, Makela K, Malker B, Miller AB, Nelson N, Patternson CC, Petterssen F, Pompe-Kirn V, Primic-Zakelj M, Prior P, Ravnihar R, Skeet RG, Skjerven JE, Smith PG, Sok M, Spengler RF, Storm HH, Stovall M, Thomkins GHO and Wall C . (1985). J. Natl. Cancer Inst., 74, 955–975.

  • Boice Jr JD, Engholm G, Kleinerman RA, Blettner M, Stovall M, Lisco H, Moloney WC, Austin DF, Bosch A, Cookfair DL, Krementz ET, Latourette HB, Merrill JA, Peters LJ, Schulz MD, Storm HH, Björkholm E, Pettersson F, Bell CMJ, Coleman MP, Fraser P, Neal FE, Prior P, Choi NW, Hislop TG, Koch M, Kreiger N, Robb D, Robson D, Thomson DH, LochmĂĽller H, von Fournier D, Frischkorn R, Kjørstad KE, Rimpela A, Pejovic M-H, Kirn VP, Stankusova H, Berrino F, Sigurdsson K, Hutchison GB and MacMahon B . (1988). Radiat. Res., 116, 3–55.

  • Boice Jr JD and McLaughlin JK . (2002). SSI Report 2002:16. Swedish Radiation Protection Authority: Stockholm.

    Google Scholar 

  • Boice Jr JD and Miller RW . (1999). Teratology, 59, 227–233.

  • Boice Jr JD, Preston D, Davis FG and Monson RR . (1991). Radiat. Res., 125, 214–222.

  • Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, Lubin JH, Preston DL, Preston RJ, Puskin JS, Ron E, Sachs RK, Samet JM, Setlow RB and Zaider M . (2003). Proc. Natl. Acad. Sci. USA, 100, 13761–13766.

  • Brenner DJ, Little JB and Sachs RK . (2001). Radiat. Res., 155, 402–408.

  • Brenner DJ and Sachs RK . (2003). Health Phys., 85, 103–108.

  • Calabrese EJ and Baldwin LA . (2003). Nature, 421, 691–692.

  • Cardis E, Gilbert ES, Carpenter L, Howe G, Kato I, Armstrong BK, Beral V, Cowper G, Douglas A, Fix J, Fry SA, Kaldor J, LavĂ© C, Salmon L, Smith PG, Voelz GL and Wiggs LD . (1995). Radiat. Res., 142, 117–132.

  • Carpenter LM . (1990). Radiat. Res., 124, 351–352.

  • Carpenter LM, Higgins CD, Douglas AJ, Maconochie NE, Omar RZ, Fraser P, Beral V and Smith PG . (1998). Br. J. Cancer, 78, 1224–1232.

  • Carr ZA, Kleinerman RA, Stovall M, Weinstock RM, Griem ML and Land CE . (2002). Radiat. Res., 157, 668–677.

  • Cohen BL . (1995). Health Phys., 68, 157–174.

  • Committee on Medical Aspects of Radiation in the Environment (COMARE) (1988). Second Report. Her Majesty's Stationery Office: London.

  • Committee on Medical Aspects of Radiation in the Environment (COMARE) (1996). Fourth Report. Department of Health: Wetherby.

  • Committee on Medical Aspects of Radiation in the Environment (COMARE) (2002). Seventh Report. National Radiological Protection Board: Chilton.

  • Cox DR . (2003). J. R. Statist. Soc. A, 166, 241–246.

  • Dalager NA, Kang HK and Mahan CM . (2000). J. Occup. Environ. Med., 42, 798–805.

  • Darby SC, Hill DC and European Collaborative Group on Rasidential Radon Lung Cancer. (2003). Radiat. Prot. Dosimetry, 104, 321–329.

  • Darby SC, Olsen JH, Doll R, Thakrar B, Brown PD, Storm HH, Barlow L, Langmark F, Teppo L and Tulinius H . (1992). BMJ, 304, 1005–1009.

  • Darby SC, Whitley E, Howe GR, Hutchings SJ, Kusiak RA, Lubin JH, Morrison HI, Tirmarche M, Tomasek L and Radford EP . (1995). J. Natl. Cancer Inst., 87, 378–384.

  • Davis FG, Boice Jr JD, Hrubec Z and Monson RR . (1989). Cancer Res., 49, 6130–6136.

  • Davis S, Kopecky KJ and Hamilton TE . (2002). Hanford Thyroid Disease Study Final Report. Fred Hutchinson Cancer Research Center: Seattle.

    Google Scholar 

  • de Vathaire F, Hawkins M, Campbell S, Oberlin O, Raquin MA, Schlienger JY, Shamsaldin A, Diallo I, Bell J, Grimaud E, Hardiman C, Lagrange JL, Daly-Schveitzer N, Panis X, Zucker JM, Sancho-Garnier H, Eschwege F, Chavaudra J and Lemerle J . (1999). Br. J. Cancer, 79, 1884–1893.

  • Dennis LK, Beane Freeman LE and VanBeek MJ . (2003). Ann. Intern. Med., 139, 966–978.

  • Dickman PW, Holm LE, Lundell G, Boice Jr JD and Hall P . (2003). Int. J. Cancer, 106, 580–587.

  • Dolk H, Elliott P, Shaddick G, Walls P and Thakrar B . (1997a). Am. J. Epidemiol., 145, 10–17.

  • Dolk H, Shaddick G, Walls P, Grundy C, Thakrar B, Kleinschmidt I and Elliott P . (1997b). Am. J. Epidemiol., 145, 1–9.

  • Doll R . (1989). J. R. Statist. Soc. A, 152, 341–351.

  • Doll . (1999). Br. J. Cancer, 81, 3–5.

  • Doll R, Evans HJ and Darby SC . (1994). Nature, 367, 678–680.

  • Doll R and Wakeford R . (1997). Br. J. Radiol., 70, 130–139.

  • Elwood JM . (1999). Environ. Health Perspect., 107 (Suppl), 155–168.

  • Eng C, Li FP, Abramson DH, Ellsworth RM, Wong FL, Goldman MB, Seddon J, Tarbell N and Boice Jr JD . (1993). J. Natl. Cancer Inst., 85, 1121–1128.

  • Fears TR, Bird CC, Guerry V D, Sagebiel RW, Gail MH, Elder DE, Halpern A, Holly EA, Hartge P and Tucker MA . (2002). Cancer Res., 62, 3992–3996.

  • Folley JH, Borges W and Yamasaki T . (1952). Am. J. Med., 13, 311–321.

  • Freedman DM, Dosemeci M and McGlynn K . (2002). Occup. Environ. Med., 59, 257–262.

  • Fry SA . (1998). Radiat. Res., 150 (Suppl), S21–S29.

  • Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S and Terrell JD . (1990). BMJ, 300, 423–429.

  • Garwicz S, Anderson H, Olsen JH, Dollner H, Hertz H, Jonmundsson G, Langmark F, Lanning M, Moller T, Sankila R and Tulinius H . (2000). Int. J. Cancer, 88, 672–678.

  • Gibson BE, Eden OB, Barrett A, Stiller CA and Draper GJ . (1988). Lancet, ii, 630.

  • Gilbert ES, Koshurnikova NA, Sokolnikov M, Khokhryakov VF, Miller S, Preston DL, Romanov SA, Shilnikova NS, Suslova KG and Vostrotin VV . (2000). Radiat. Res., 154, 246–252.

  • Gilbert ES, Tarone R, Bouville A and Ron E . (1998). J. Natl. Cancer Inst., 90, 1654–1660.

  • Gilliland FD, Hunt WC, Archer VE and Saccomanno G . (2000). Health Phys., 79, 365–372.

  • Gilman EA and Knox EG . (1998). Br. J. Cancer, 77, 842–849.

  • Grosche B, Land C, Bauer S, Pivina LM, Abylkassimova ZN and Gusev BI . (2002). Radiat. Environ. Biophys., 41, 75–80.

  • Groves FD, Page WF, Gridley G, Lisimaque L, Stewart PA, Tarone RE, Gail MH, Boice Jr JD and Beebe GW . (2002). Am. J. Epidemiol., 155, 810–818.

  • Guizard AV, Boutou O, Pottier V, Troussard X, Pheby D, Launoy G, Stama R and Spira A . (2001). J. Epidemiol. Commun. Health, 55, 469–474.

  • Gundestrup M and Storm HH . (1999). Lancet, 354, 2029–2031.

  • Hahn K, Schnell-Inderst P, Grosche B and Holm LE . (2001). Radiat. Res., 156, 61–70.

  • Hamilton TE, van Belle G and LoGerfo JP . (1987). JAMA, 258, 629–635.

  • Harrison JD and Muirhead CR . (2003). Int. J. Radiat. Biol., 79, 1–13.

  • Harvard Center for Cancer Prevention (1996). Cancer Causes Control, 7 (Suppl 1), S41–S43.

  • Hatch EE, Kleinerman RA, Linet MS, Tarone RE, Kaune WT, Auvinen A, Baris D, Robison LL and Wacholder S . (2000). Epidemiology, 11, 189–198.

  • Hatch MC, Beyea J, Nieves JW and Susser M . (1990). Am. J. Epidemiol., 132, 397–412.

  • Henshaw DL, Eatough JP and Richardson RB . (1990). Lancet, 335, 1008–1012.

  • Hocking B, Gordon IR, Grain HL and Hatfield GE . (1996). Med. J. Aust., 165, 601–605.

  • Hollingsworth DR, Hamilton HB, Tamagaki H and Beebe GW . (1963). Medicine, 42, 47–71.

  • Howard JE, Vaswani A and Heotis P . (1997). Health Phys., 73, 190–198.

  • Howe GR . (1995). Radiat. Res., 142, 295–304.

  • Howe GR and McLaughlin J . (1996). Radiat. Res., 145, 694–707.

  • Huncharek M and Kupelnick B . (2002). Am. J. Public Health, 92, 1173–1177.

  • Independent Expert Group on Mobile Phones (IEGMP) (2000). Mobile Phones and Health (Chairman: Sir William Stewart). Independent Expert Group on Mobile Phones: Chilton.

  • Institute of Medicine (2000). The Five Series Study: Mortality of Military Participants in U.S. Nuclear Weapons Tests. National Academy Press: Washington, DC.

  • International Agency for Research on Cancer (IARC) (1992). IARC Monographs on the Evaluation of Carcinogenic Risk to Humans Volume 55 Solar and Ultraviolet Radiation. IARC Press: Lyon.

  • International Agency for Research on Cancer (IARC) (2000). IARC Monographs on the Evaluation of Carcinogenic Risk to Humans Volume 75 Ionizing Radiation, Part 1: X- and Gamma (Îł)-Radiation, and Neutrons. IARC Press: Lyon.

  • International Agency for Research on Cancer (IARC) (2001). IARC Monographs on the Evaluation of Carcinogenic Risk to Humans Volume 78 Ionizing Radiation, Part 2: Some Internally Deposited Radionuclides. IARC Press: Lyon.

  • International Agency for Research on Cancer (IARC) (2002). IARC Monographs on the Evaluation of Carcinogenic Risk to Humans Volume 80 Non-ionizing Radiation, Part 1: Static and Extremely Low Frequency (ELF) Electric and Magnetic Fields. IARC Press: Lyon.

  • International Commission on Radiological Protection (ICRP) (1991a). 1990 Recommendations of the International Commission on Radiological Protection ICRP, Publication 60. Annals of the ICRP Vol. 21, Nos. 1–3. Pergaman: Oxford.

  • International Commission on Radiological Protection (ICRP) (1991b). Risks Associated with Ionising Radiations. Annals of the ICRP Vol. 22, No. 1. Pergaman: Oxford.

  • International Commission on Radiological Protection (ICRP) (1998). Genetic Susceptibility to Cancer. Publication 79. Annals of the ICRP Vol. 28, No. 1/2. Elsevier: Amsterdam.

  • Ivanov EP, Tolochko GV, Shuvaeva LP, Ivanov VE, Iaroshevich RF, Becker S, Nekolla E and Kellerer AM . (1998). Radiat. Environ. Biophys., 37, 53–55.

  • Ivanov VK, Gorski AI, Maksioutov MA, Tsyb AF and Souchkevitch GN . (2001). Health Phys., 81, 514–521.

  • Ivanov VK, Gorski AI, Maksioutov MA, Vlasov OK, Godko AM, Tsyb AF, Tirmarche M, Valenty M and Verger P . (2003). Health Phys., 84, 46–60.

  • Ivanov VK, Gorski AI, Tsyb AF, Ivanov SI, Naumenko RN and Ivanova LV . (2004). Radiat. Environ. Biophys., 43, 35–42.

  • Ivanov VK, Tsyb AF, Gorsky AI, Maksyutov MA, Rastopchin EM, Konogorov AP, Korelo AM, Biryukov AP and Matyash VA . (1997a). Radiat. Environ. Biophys., 36, 9–16.

  • Ivanov VK, Tsyb AF, Konogorov AP, Rastopchin EM and Khait SE . (1997b). J. Radiol. Prot., 17, 137–157.

  • Ivanov VK, Tsyb AF, Petrov AV, Maksioutov MA, Shilyaeva TP and Kochergina EV . (2002). Radiat. Environ. Biophys., 41, 195–198.

  • Izumi S, Suyama A and Koyama K . (2003). Int. J. Cancer, 107, 292–297.

  • Jacob P, Kenigsberg Y, Goulko G, Buglova E, Gering F, Golovneva A, Kruk J and Demidchik EP . (2000). Radiat. Environ. Biophys., 39, 25–31.

  • Karagas MR, Stannard VA, Mott LA, Slattery MJ, Spencer SK and Weinstock MA . (2002). J. Natl. Cancer Inst., 94, 224–226.

  • Kerber RA, Till JE, Simon SL, Lyon JL, Thomas DC, Preston-Martin S, Rallison ML, Lloyd RD and Stevens W . (1993). JAMA, 270, 2076–2082.

  • Kesminiene A, Cardis E, Tenet V, Ivanov VK, Kurtinaitis J, Malakhova I, Stengrevics A and Tekkel M . (2002). J. Radiol. Prot., 22, A137–141.

  • Kinlen LJ . (2000). Radiol. Prot. Bull., 226, 9–18.

  • Kleinerman RA, Kaune WT, Hatch EE, Wacholder S, Linet MS, Robison LL, Niwa S and Tarone RE . (2000). Am. J. Epidemiol., 151, 512–515.

  • Koshurnikova NA, Gilbert ES, Sokolnikov M, Khokhryakov VF, Miller S, Preston DL, Romanov SA, Shilnikova NS, Suslova KG and Vostrotin VV . (2000). Radiat. Res., 154, 237–245.

  • Kossenko MM, Preston DL, Krestinina LY, Degteva MO, Startsev NV, Thomas T, Vyushkova OV, Anspaugh LR, Napier BA, Kozheurov VP, Ron E and Akleyev AV . (2002). Radiat. Environ. Biophys., 41, 45–48.

  • Kreisheimer M, Sokolnikov ME, Koshurnikova NA, Khokhryakov VF, Romanow SA, Shilnikova NS, Okatenko PV, Nekolla EA and Kellerer AM . (2003). Radiat. Environ. Biophys., 42, 129–135.

  • Lagarde F, Axelsson G, Damber L, Mellander H, Nyberg F and Pershagen G . (2001). Epidemiology, 12, 396–404.

  • Land CE, Hayakawa N, Machado SG, Yamada Y, Pike MC, Akiba S and Tokunaga M . (1994). Cancer Causes Control, 5, 167–176.

  • Land CE, Tokunaga M, Koyama K, Soda M, Preston DL, Nishimori I and Tokuoka S . (2003). Radiat. Res., 160, 707–717.

  • Land CE, Tokunaga M, Tokuoka S and Nakamura N . (1993). Lancet, 342, 237.

  • Langner I, Blettner M, Gundestrup M, Storm H, Aspholm R, Auvinen A, Pukkala E, Hammer GP, Zeeb H, Hrafnkelsson J, Rafnsson V, Tulinius H, De Angelis G, Verdecchia A, Haldorsen T, Tveten U, Eliasch Dagger H, Hammar N and Linnersjo A . (2004). Radiat. Environ. Biophys., 42, 247–256.

  • Laurier D, Valenty M and Tirmarche M . (2001). Health Phys., 81, 272–288.

  • Linet MS, Hatch EE, Kleinerman RA, Robison LL, Kaune WT, Friedman DR, Severson RK, Haines CM, Hartsock CT, Niwa S, Wacholder S and Tarone RE . (1997). N. Engl. J. Med., 337, 1–7.

  • Little MP . (2001). Int. J. Radiat. Biol., 77, 431–464 745–760.

  • Little MP . (2002a). Int. J. Radiat. Biol., 78, 1001–1010.

  • Little MP . (2002b). Int. J. Radiat. Biol., 78, 145–163.

  • Little MP and Boice Jr JD . (1999). Radiat. Res., 151, 218–224.

  • Little MP and Charles MW . (1990). Health Phys., 59, 765–775.

  • Little MP and Charles MW . (1997). Int. J. Radiat. Biol., 71, 589–602.

  • Little MP and Wakeford R . (2001). Radiat. Res., 156, 695–699.

  • Little MP, Weiss HA, Boice Jr JD, Darby SC, Day NE and Muirhead CR . (1999). Radiat. Res., 152, 280–292.

  • Lubin JH . (2003). Radiat. Prot. Dosimetry, 104, 315–319.

  • Lubin JH and Boice Jr JD . (1997). J. Natl. Cancer Inst., 89, 49–57.

  • Lubin JH, Boice Jr JD, Edling C, Hornung RW, Howe G, Kunz E, Kusiak RA, Morrison HI, Radford EP, Samet JM, Tirmarche M, Woodward A, Yao SX and Pierce DA . (1995). J. Natl. Cancer Inst., 87, 817–827.

  • Lubin JH, Linet MS, Boice Jr JD, Buckley J, Conrath SM, Hatch EE, Kleinerman RA, Tarone RE, Wacholder S and Robison LL . (1998). J. Natl. Cancer Inst., 90, 294–300.

  • Lubin JH, Tomasek L, Edling C, Hornung RW, Howe G, Kunz E, Kusiak RA, Morrison HI, Radford EP, Samet JM, Tirmarche M, Woodward A and Yao SX . (1997). Radiat. Res., 147, 126–134.

  • Lubin JH, Wang ZY, Boice Jr JD, Xu ZY, Blot WJ, De Wang L and Kleinerman RA . (2004). Int. J. Cancer, 109, 132–137.

  • Maldonado JL, Fridlyand J, Patel H, Jain AN, Busam K, Kageshita T, Ono T, Albertson DG, Pinkel D and Bastian BC . (2003). J. Natl. Cancer Inst., 95, 1878–1890.

  • March HC . (1944). Radiology, 43, 275–278.

  • McKenzie DR, Yin Y and Morrell S . (1998). Aust. NZ J. Public Health, 22 (Suppl), 360–367.

  • Michelozzi P, Capon A, Kirchmayer U, Forastiere F, Biggeri A, Barca A and Perucci CA . (2002). Am. J. Epidemiol., 155, 1096–1103.

  • Milan T, Verkasalo PK, Kaprio J, Koskenvuo M and Pukkala E . (2002). Br. J. Dermatol., 147, 509–512.

  • Mohan AK, Hauptmann M, Freedman DM, Ron E, Matanoski GM, Lubin JH, Alexander BH, Boice Jr JD, Doody MM and Linet MS . (2003). Int. J. Cancer, 103, 259–267.

  • Mohan AK, Hauptmann M, Linet MS, Ron E, Lubin JH, Freedman DM, Alexander BH, Boice Jr JD, Doody MM and Matanoski GM . (2002). J. Natl. Cancer Inst., 94, 943–948.

  • Morgan RW, Kelsh MA, Zhao K, Exuzides KA, Heringer S and Negrete W . (2000). Epidemiology, 11, 118–127.

  • Moysich KB, Menezes RJ and Michalek AM . (2002). Lancet Oncol., 3, 269–279.

  • Muirhead CR, Bingham D, Haylock RG, O'Hagan JA, Goodill AA, Berridge GL, English MA, Hunter N and Kendall GM . (2003). Occup. Environ. Med., 60, 165–172.

  • Muirhead CR, Goodill AA, Haylock RG, Vokes J, Little MP, Jackson DA, O'Hagan JA, Thomas JM, Kendall GM, Silk TJ, Bingham D and Berridge GL . (1999). J. Radiol. Prot., 19, 3–26.

  • National Council on Radiation Protection and Measurements (NCRP) (1993). Risk Estimates for Radiation Protection. NCRP Report No. 115. National Council on Radiation Protection and Measurements: Bethesda, MD.

  • National Council on Radiation Protection and Measurements (NCRP) (2001a). Liver Cancer Risk from Internally-deposited Radionuclides. NCRP Report No. 135. National Council on Radiation Protection and Measurements: Bethesda, MD.

  • National Council on Radiation Protection and Measurements (NCRP) (2001b). Evaluation of the Linear-nonthreshold Dose–Response Model for Ionizing Radiation. NCRP Report No. 136. National Council on Radiation Protection and Measurements: Bethesda, MD.

  • National Radiological Protection Board (NRPB) (1993). Estimates of Late Radiation Risks to the UK Population, Documents of the NRPB, Vol. 4, No. 4. National Radiological Protection Board: Chilton.

  • National Radiological Protection Board (NRPB) (1995). Risk of Radiation-induced Cancer at Low Doses and Dose Rates for Radiation Protection Purposes, Documents of the NRPB, Vol. 6, No. 1. National Radiological Protection Board: Chilton.

  • National Research Council (NRC), Committee on Health Risks of Exposure to Radon (1999). Health Effects of Exposure to Radon, BEIR VI. National Academy Press: Washington, DC.

  • National Research Council (NRC), Committee on the Biological Effects of Ionizing Radiations (1990). Health Effects of Exposure to Low Levels of Ionizing Radiation, BEIR V. National Academy Press: Washington, DC.

  • Naumburg E, Bellocco R, Cnattingius S, Hall P and Ekbom A . (2000). BMJ, 320, 282–283.

  • Nekolla EA, Kreisheimer M, Kellerer AM, Kuse-Isingschulte M, Gossner W and Spiess H . (2000). Radiat. Res., 153, 93–103.

  • Nicholas JS, Lackland DT, Dosemeci M, Mohr Jr LC, Dunbar JB, Grosche B and Hoel DG . (1998). J. Occup. Environ. Med., 40, 980–985.

  • Omar RZ, Barber JA and Smith PG . (1999). Br. J. Cancer, 79, 1288–1301.

  • Parkin DM, Clayton D, Black RJ, Masuyer E, Friedl HP, Ivanov E, Sinnaeve J, Tzvetansky CG, Geryk E, Storm HH, Rahu M, Pukkala E, Bernard JL, Carli PM, L'Huilluier MC, Menegoz F, Schaffer P, Schraub S, Kaatsch P, Michaelis J, Apjok E, Schuler D, Crosignani P, Magnani C, Terracini B, Stengrevics A, Kriauciunas R, Coebergh JW, Langmark F, Zatonski W, Tulbure R, Boukhny A, Merabishvili V, Piesko I, Kramarova E, Pompe-Kirn V, Barlow L, Enderlin F, Levi F, Raymond L, SchĂĽler G, Torhorsi J, Stiller CA, Sharp L and Bennett BG . (1996). Br. J. Cancer, 73, 1006–1012.

  • Pearce N, Winkelmann R, Kennedy J, Lewis S, Purdie G, Slater T, Prior I and Fraser J . (1997). Cancer Causes Control, 8, 139–145.

  • Petridou E, Trichopoulos D, Dessypris N, Flytzani V, Haidas S, Kalmanti M, Koliouskas D, Kosmidis H, Piperopoulou F and Tzortzatou F . (1996). Nature, 382, 352–353.

  • Pierce DA and Preston DL . (2000). Radiat. Res., 154, 178–186.

  • Pierce DA, Sharp GB and Mabuchi K . (2003). Radiat. Res., 159, 511–520.

  • Pierce DA, Shimizu Y, Preston DL, Vaeth M and Mabuchi K . (1996). Radiat. Res., 146, 1–27.

  • Preston D, Kusumi S, Tomonaga M, Izumi S, Ron E, Kuranoto A, Kamada N, Dohy H, Matsuo T, Nonaka H, Thompson DE, Soda M and Mabuchi K . (1994). Radiat. Res., 137 (Suppl), S68–S97.

  • Preston DL, Mattsson A, Holmberg E, Shore R, Hildreth NG and Boice Jr JD . (2002). Radiat. Res., 158, 220–235 666.

  • Preston DL, Shimizu Y, Pierce DA, Suyama A and Mabuchi K . (2003). Radiat. Res., 160, 381–407.

  • Preston RJ . (2003). J. Radiol. Prot., 23, 263–268.

  • Puskin JS . (2003). Health Phys., 84, 526–532.

  • Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA and Boice Jr JD . (1995). Radiat. Res., 141, 259–277.

  • Ron E, Preston DL, Kishikawa M, Kobuke T, Iseki M, Tokuoka S, Tokunaga M and Mabuchi K . (1998). Cancer Causes Control, 9, 393–401.

  • Ron E, Preston DL, Mabuchi K, Thompson DE and Soda M . (1994). Radiat. Res., 137 (Suppl), S98–S112.

  • Rooney C, Beral V, Maconochie N, Fraser P and Davies G . (1993). BMJ, 307, 1391–1397.

  • Rothman KJ . (2000). Lancet, 356, 1837–1840.

  • Scotto J, Fraumeni Jr JF and Fears TR . (1996). Cancer Epidemiology and Prevention, 2nd edn. Schottenfeld D and Fraumeni Jr JF (eds). Oxford University Press: New York, pp. 355–372.

    Google Scholar 

  • Shakhtarin V, Tsyb A, Stepanenko V, Orlov M, Kopecky K and Davis S . (2003). Int. J. Epidemiol., 32, 584–591.

  • Shilnikova NS, Preston DL, Ron E, Gilbert ES, Vassilenko EK, Romanov SA, Kuznetsova IS, Sokolnikov ME, Okatenko PV, Kreslov VV and Koshurnikova NA . (2003). Radiat. Res., 159, 787–798.

  • Shore RE, Moseson M, Xue X, Tse Y, Harley N and Pasternack BS . (2002). Radiat. Res., 157, 410–418.

  • Shu XO, Potter JD, Linet MS, Severson RK, Han D, Kersey JH, Neglia JP, Trigg ME and Robison LL . (2002). Cancer Epidemiol. Biomarkers Prev., 11, 177–185.

  • Sigurdson AJ, Doody MM, Rao RS, Freedman DM, Alexander BH, Hauptmann M, Mohan AK, Yoshinaga S, Hill DA, Tarone R, Mabuchi K, Ron E and Linet MS . (2003). Cancer, 97, 3080–3089.

  • Simonsen LC, Wilson JW, Kim MH and Cucinotta FA . (2000). Health Phys., 79, 515–525.

  • Skinner J, Mee TJ, Blackwell RP, Maslanyj MP, Simpson J, Allen SG, Day NE, Cheng KK, Gilman E, Williams D, Cartwright R, Craft A, Birch JM, Eden OB, McKinney PA, Deacon J, Peto J, Beral V, Roman E, Elwood P, Alexander FE, Mott M, Chilvers CE, Muir K, Doll R, Taylor CM, Greaves M, Goodhead D, Fry FA, Adams G, Law G and United Kingdom Childhood Cancer Study Investigators. (2000). Br. J. Cancer, 87, 1257–1266.

  • Sorahan T, Lancashire R, Stewart A and Peck I . (1995). Br. J. Obstet. Gynaecol., 102, 831–832.

  • Steiner M, Burkart W, Grosche B, Kaletsch U and Michaelis J . (1998). Radiat. Environ. Biophys., 37, 87–93.

  • Stevens W, Thomas DC, Lyon JL, Till JE, Kerber RA, Simon SL, Lloyd RD, Elghany NA and Preston-Martin S . (1990). JAMA, 264, 585–591.

  • Stewart AM and Kneale GW . (2000). Int. J. Epidemiol., 29, 708–714.

  • Straume T, Rugel G, Marchetti AA, Ruhm W, Korschinek G, McAninch JE, Carroll K, Egbert S, Faestermann T, Knie K, Martinelli R, Wallner A and Wallner C . (2003). Nature, 424, 539–542.

  • Takahashi T, Schoemaker MJ, Trott KR, Simon SL, Fujimori K, Nakashima N Fukao A and Saito H . (2003). J. Epidemiol., 13, 99–107.

  • Thompson DE, Mabuchi K, Ron E, Soda M, Tokunaga M, Ochikubo S, Sugimoto S, Ikeda T, Terasaki M, Izumi S and Preston DL . (1994). Radiat. Res., 137 (Suppl), S17–S67.

  • Tokunaga M, Land CE, Tokuoka S, Nishimori I, Soda M and Akiba S . (1994). Radiat. Res., 138, 209–223.

  • Travis LB, Gospodarowicz M, Curtis RE, Clarke EA, Andersson M, Glimelius B, Joensuu T, Lynch CF, van Leeuwen FE, Holowaty E, Storm H, Glimelius I, Pukkala E, Stovall M, Fraumeni Jr JF, Boice Jr JD and Gilbert E . (2002). J. Natl. Cancer Inst., 94, 182–192.

  • Travis LB, Hauptmann M, Gaul LK, Storm HH, Goldman MB, Nyberg U, Berger E, Janower ML, Hall P, Monson RR, Holm LE, Land CE, Schottenfeld D, Boice Jr JD and Andersson M . (2003a). Radiat. Res., 160, 691–706.

  • Travis LB, Hill DA, Dores GM, Gospodarowicz M, van Leeuwen FE, Holowaty E, Glimelius B, Andersson M, Wiklund T, Lynch CF, Van't Veer MB, Glimelius I, Storm H, Pukkala E, Stovall M, Curtis R, Boice Jr JD and Gilbert E . (2003b). JAMA, 290, 465–475.

  • Travis LB, Land CE, Andersson M, Nyberg U, Goldman MB, Knudson Gaul L, Berger E, Storm HH, Hall P, Auvinen A, Janower ML, Holm LE, Monson RR, Schottenfeld D and Boice Jr JD . (2001). Radiat. Res., 156, 136–150.

  • Travis LB, Weeks J, Curtis RE, Chaffey JT, Stovall M, Banks PM and Boice Jr JD . (1996). J. Clin. Oncol., 14, 565–571.

  • Tucker MA and Goldstein AM . (2003). Oncogene, 22, 3042–3052.

  • UK Childhood Cancer Study Investigators (1999). Lancet, 354, 1925–1931.

  • UK Childhood Cancer Study Investigators (2000). Br. J. Cancer, 83, 1573–1580.

  • UK Childhood Cancer Study Investigators (2002a). Br. J. Cancer, 86, 1721–1726.

  • UK Childhood Cancer Study Investigators (2002b). Br. J. Cancer, 86, 1727–1731.

  • United Nations Scientific Committee on the Effects of Atomic Radiation (1994). Sources and Effects of Ionizing Radiation. UNSCEAR 1994 Report to the General Assembly, with Scientific Annexes. United Nations: New York.

  • United Nations Scientific Committee on the Effects of Atomic Radiation (2000). Sources and Effects of Ionizing Radiation. UNSCEAR 2000 Report to the General Assembly, with Scientific Annexes. United Nations: New York.

  • Vajdic CM, Kricker A, Giblin M, McKenzie J, Aitken J, Giles GG and Armstrong BK . (2003). Int. J. Cancer, 105, 117–122.

  • van Leeuwen FE, Klokman WJ, Stovall M, Dahler EC, van't Veer MB, Noordijk EM, Crommelin MA, Aleman BM, Broeks A, Gospodarowicz M, Travis LB and Russell NS . (2003). J. Natl. Cancer Inst., 95, 971–980.

  • Veierod MB, Weiderpass E, Thorn M, Hansson J, Lund E, Armstrong B and Adami HO . (2003). J. Natl. Cancer Inst., 95, 1530–1538.

  • Wakeford R and Little MP . (2003). Int. J. Radiat. Biol., 79, 293–309.

  • Wang JX, Zhang LA, Li BX, Zhao YC, Wang ZQ, Zhang JY and Aoyama T . (2002a). Health Phys., 82, 455–466.

  • Wang Z, Lubin JH, Wang L, Zhang S, Boice Jr JD, Cui H, Zhang S, Conrath S, Xia Y, Shang B, Brenner A, Lei S, Metayer C, Cao J, Chen KW, Lei S and Kleinerman RA . (2002b). Am. J. Epidemiol., 155, 554–564.

  • Wei L and Sugahara T (eds). (2000). J. Radiat. Res., 41 (Suppl), S1–S74.

  • Weiss HA, Darby SC and Doll R . (1994). Int. J. Cancer, 59, 327–338.

  • Weiss HA, Darby SC, Fearn T and Doll R . (1995). Radiat. Res., 142, 1–11.

  • Wertheimer N and Leeper E . (1979). Am. J. Epidemiol., 109, 273–284.

  • Wheldon TE . (1989). J. R. Statist. Soc. A, 152, 327–339.

  • Whiteman DC, Watt P, Purdie DM, Hughes MC, Hayward NK and Green AC . (2003). J. Natl. Cancer Inst., 95, 806–812.

  • Whiteman DC, Whiteman CA and Green AC . (2001). Cancer Causes Control, 12, 69–82.

  • Wick RR, Nekolla EA, Gossner W and Kellerer AM . (1999). Radiat. Res., 152 (6 Suppl), S8–S11.

  • Williams D . (2002). Nat. Rev. Cancer, 2, 543–549.

  • Wing S, Richardson D, Armstrong D and Crawford-Brown D . (1997). Environ. Health Perspect., 105, 52–57.

  • World Health Organization (WHO) (1994). Ultraviolet Radiation. Environmental Health Criteria, No. 160. World Health Organization: Geneva.

  • Yoshimoto Y, Neel JV, Schull WJ, Kato H, Soda M, Eto R and Mabuchi K . (1990). Am. J. Hum. Genet., 46, 1041–1052.

  • Zeeb H, Blettner M, Langner I, Hammer GP, Ballard TJ, Santaquilani M, Gundestrup M, Storm H, Haldorsen T, Tveten U, Hammar N, Linnersjo A, Velonakis E, Tzonou A, Auvinen A, Pukkala E, Rafnsson V and Hrafnkelsson J . (2003). Am. J. Epidemiol., 158, 35–46.

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Wakeford, R. The cancer epidemiology of radiation. Oncogene 23, 6404–6428 (2004). https://doi.org/10.1038/sj.onc.1207896

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