Figure 2 | Oncogene

Figure 2

From: DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway

Figure 2

Structure of the DKK1 promoter. (a) Schematic representation of the human DKK1 promoter. The human DKK1 promoter has a TATA box (TATA) near the transcription start site (TSS) and two highly conserved regions within 1 kbp upstream from the TSS. Two consensus TCF-binding elements were identified in each region, and were named TBE1, TBE2, TBE3, and TBE4, starting from distal side. The upstream most upstream nucleotide residues in the TATA box and four TBEs are shown, with the transcription start site taken as the zero. The nucleotide sequence is available from DBTSS (http://dbtss.hgc.jp/). (b) Alignment of the two highly conserved regions between human and mouse sequences. The conserved regions and the four potential TBEs are marked with rectangles

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