Figure 1 | Oncogene

Figure 1

From: DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway

Figure 1

In silico screening procedure to identify TCF target candidates by phylogenetic footprinting and consensus sequence search. We first prepared promoter sequences of human genes and the cDNA counterparts of each. Next, we assumed the genomic upstream regions of the mouse homologs to be mouse promoters and extracted highly conserved regions from the local alignments between orthologous human and mouse promoter sequences. We selected genes that had conserved consensus sequences in these regions for TCF-binding elements (TBE, 5′-CTTTG[A/T][A/T]-3′) as candidates for TCF target genes

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