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Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation

Oncogene volume 23, pages 6726–6735 (2004)Cite this article

Abstract

We have determined the expression profiles of cdh7, and the related cdh20 during development. Both transcripts are found in the adult brain, but only cadherin-20 mRNA was detected during embryogenesis. In mouse embryos, cadherin-20 is synthesized by the forebrain, anterior neural ridge, developing visual system, primitive external granular layer of the cerebellum and a subset of neural crest cells likely to develop into melanoblasts. We found that the other embryonic tissues in which cadherin-20 was synthesized depended on genetic background. Melanoma cell lines contained transcripts for cadherin-7 but not for cadherin-20. The majority of the malignant melanoma cell lines produced N-cadherin (N-Cad) and/or cadherin-7 whereas melanocyte cell lines did not. The converse was observed for E-cadherin (E-Cad). Our data suggest that during development cadherin-20 is a key player in compartmentalization of the neural tube and establishment of neural circuitry. Finally, during oncogenesis, cadherin-7, N-cad and E-cad could be used as an efficient marker set for melanoma.

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Acknowledgements

RM holds fellowships from Fondation de France and Fondation pour la Recherche Médicale. This research was financed by Fondation de France, Ligue contre le cancer, GEFLUC and ARC. We thank Drs Delmas and Martinozzi for constructive criticism. Drs Asher, Kispert, Herrmann, Lallemand, Etchevers and Waseff provided useful comments. We thank Drs Jouanneau and Régnier for L and P melanocyte RNA, Drs van den Eynde and Baserga for melanoma lines, Dr Vernier for murine brain cDNA libraries and Y Bourgeois for animal husbandry. The murine cdh7 cDNA and primary amino acid sequences have been deposited at GenBank under accession numbers AY267034 and AAP94032, respectively.

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Authors and Affiliations

  1. Developmental Genetics of Melanocytes, UMR146 CNRS, Institut Curie, Bat. 110, Orsay Cedex, 91405, France

    Robert Moore, Delphine Champeval, Laurence Denat, Sylvia Julien-Grille & Lionel Larue

  2. Brain Development Research, The Howard Florey Institute, The University of Melbourne, Parkville, 3052, Victoria, Australia

    Seong-Seng Tan

  3. U520 INSERM, Institut Curie, 26 rue d'Ulm, Paris, 75005, France

    Florence Faure

Authors
  1. Robert Moore
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  2. Delphine Champeval
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  5. Florence Faure
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  6. Sylvia Julien-Grille
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Correspondence to Lionel Larue.

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Moore, R., Champeval, D., Denat, L. et al. Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation. Oncogene 23, 6726–6735 (2004). https://doi.org/10.1038/sj.onc.1207675

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