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Epigenetic gene silencing by Runx proteins

Oncogene volume 23, pages 4341–4345 (2004)Cite this article

Abstract

Runx family proteins have the potential for either activating or suppressing gene expression in a context-dependent manner. There are several mechanisms by which transcriptional repression can occur. A wide range of locus inactivation, that is often called gene silencing, is thought to be achieved by chromatin modifications. Recently, Runx family proteins were found to have an essential role in either temporal transcriptional repression or irreversible epigenetic silencing at the CD4 locus through binding to a CD4 silencer at different stages of development. These findings link Runx function to epigenetic gene regulation, and shed new light on the mechanisms by which Runx represses target gene expression.

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References

  • Chakraborty S, Sinha KK, Senyuk V and Nucifora G . (2003). Oncogene, 22, 5229–5237.

  • Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR and Crabtree GR . (2002). Nature, 418, 195–199.

  • Donda A, Schulz M, Burki K, De Libero G and Uematsu Y . (1996). Eur. J. Immunol., 26, 493–500.

  • Ellmeier W, Sawada S and Littman DR . (1999). Annu. Rev. Immunol., 17, 523–554.

  • Ellmeier W, Sunshine MJ, Maschek R and Littman DR . (2002). Immunity, 16, 623–634.

  • Festenstein R and Kioussis D . (2000). Curr. Opin. Genet. Dev., 10, 199–203.

  • Festenstein R, Sharghi-Namini S, Fox M, Roderick K, Tolaini M, Norton T, Saveliev A, Kioussis D and Singh P . (1999). Nat. Genet., 23, 457–461.

  • Garefalaki A, Coles M, Hirschberg S, Mavria G, Norton T, Hostert A and Kioussis D . (2002). Immunity, 16, 635–647.

  • Jain M, Arvanitis C, Chu K, Dewey W, Leonhardt E, Trinh M, Sundberg CD, Bishop JM and Felsher DW . (2002). Science, 297, 102–104.

  • Jenuwein T and Allis CD . (2001). Science, 293, 1074–1080.

  • Kioussis D and Ellmeier W . (2002). Nat. Rev. Immunol., 2, 909–919.

  • Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA and Dick JE . (1994). Nature, 367, 645–648.

  • Leung RK, Thomson K, Gallimore A, Jones E, Van den Broek M, Sierro S, Alsheikhly AR, McMichael A and Rahemtulla A . (2001). Nat. Immunol., 2, 1167–1173.

  • Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z and Groner Y . (1998). Proc. Natl. Acad. Sci. USA, 95, 11590–11595.

  • Lutterbach B, Westendorf JJ, Linggi B, Isaac S, Seto E and Hiebert SW . (2000). J. Biol. Chem., 275, 651–656.

  • Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y and Ohki M . (1991). Proc. Natl. Acad. Sci. USA, 88, 10431–10434.

  • Nakayama J, Rice JC, Strahl BD, Allis CD and Grewal SI . (2001). Science, 292, 110–113.

  • Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O'Carroll D, Firestein R, Cleary M, Jenuwein T, Herrera RE and Kouzarides T . (2001). Nature, 412, 561–565.

  • Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, Suzushima H, Takatsuki K, Kanno T, Shigesada K and Ito Y . (1999). Blood, 93, 1817–1824.

  • Satake M, Nomura S, Yamaguchi-Iwai Y, Takahama Y, Hashimoto Y, Niki M, Kitamura Y and Ito Y . (1995). Mol. Cell. Biol., 15, 1662–1670.

  • Sawada S, Scarborough JD, Killeen N and Littman DR . (1994). Cell, 77, 917–929.

  • Sebzda E, Mariathasan S, Ohteki T, Jones R, Bachmann MF and Ohashi PS . (1999). Annu. Rev. Immunol., 17, 829–874.

  • Siu G, Wurster AL, Duncan DD, Soliman TM and Hedrick SM . (1994). EMBO J., 13, 3570–3579.

  • Taniuchi I, Ellmeier W and Littman DR . (2004). Adv. Immunol., in press.

  • Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y and Littman DR . (2002a). Cell, 111, 621–633.

  • Taniuchi I, Sunshine MJ, Festenstein R and Littman DR . (2002b). Mol. Cell, 10, 1083–1096.

  • von Boehmer H, Swat W and Kisielow P . (1993). Immunol. Rev., 135, 67–79.

  • Wakimoto BT . (1998). Cell, 93, 321–324.

  • Wheeler JC, Shigesada K, Gergen JP and Ito Y . (2000). Semin. Cell Dev. Biol., 11, 369–375.

  • Woolf E, Xiao C, Fainaru O, Lotem J, Rosen D, Negreanu V, Bernstein Y, Goldenberg D, Brenner O, Berke G, Levanon D and Groner Y . (2003). Proc. Natl. Acad. Sci. USA, 100, 7731–7736.

  • Zou YR, Sunshine MJ, Taniuchi I, Hatam F, Killeen N and Littman DR . (2001). Nat. Genet., 29, 332–336.

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Authors and Affiliations

  1. Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, 230-0045, Japan

    Ichiro Taniuchi

  2. Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Japan

    Ichiro Taniuchi

  3. PREST, JST, Japan

    Ichiro Taniuchi

  4. Howard Hughes Medical Institute, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, 10016, NY, USA

    Dan R Littman

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  1. Ichiro Taniuchi
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  2. Dan R Littman
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Correspondence to Ichiro Taniuchi.

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Taniuchi, I., Littman, D. Epigenetic gene silencing by Runx proteins. Oncogene 23, 4341–4345 (2004). https://doi.org/10.1038/sj.onc.1207671

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