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The role of c-myc in regulation of translation initiation

Oncogene volume 23, pages 3217–3221 (2004)Cite this article

Abstract

Translation initiation is important for the regulation of both cell growth and cell division. It is uniquely poised to coordinate overall cell proliferation by its effects on both growth and division. A number of translation initiation factors are transcriptional targets of c-myc in a variety of assays. In particular, the mRNA cap-binding protein eIF4E has a myc-binding sequence in its promoter that is myc responsive in reporter assays and contains a high-affinity myc-binding site in chromosome immunoprecipitation experiments. Several differential expression screens have demonstrated altered levels of eIF4E, along with several other translation initiation factors, in response to alterations of c-myc levels. The potential for eIF4E and other translational control elements to mediate myc's transforming functions is particularly important because eIF4E is itself a known oncogenic factor. The ability of translation initiation factors to affect both cell division control and cell growth control coincides with myc's remarkable effects on both cell growth and cell division.

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References

  • Amati B, Frank SR, Donjerkovic D and Taubert S . (2001). Biochim. Biophys. Acta, 1471, M135–M145.

  • Baserga R . (1985). The Biology of Cell Reproduction. Harvard University Press: Cambridge, Mass.

    Google Scholar 

  • Bello-Fernandez C, Packham G and Cleveland JL . (1993). Proc. Natl. Acad. Sci.USA, 90, 7804–7808.

  • Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN and Weintraub H . (1990). Science, 250, 1149–1151.

  • Boon K, Caron HN, van Asperen R, Valentijn L, Hermus MC, van Sluis P, Roobeek I, Weis I, Voute PA, Schwab M and Versteeg R . (2001). EMBO J., 20, 1383–1393.

  • Brewer JW, Hendershot LM, Sherr CJ and Diehl JA . (1999). Proc. Natl. Acad. Sci. USA, 96, 8505–8510.

  • Bush A, Mateyak M, Dugan K, Obaya A, Adachi S, Sedivy J and Cole M . (1998). Genes. Dev., 12, 3797–3802.

  • Coller HA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN and Golub TR . (2000). Proc. Natl. Acad. Sci. USA, 97, 3260–3265.

  • Collier JJ, Doan TT, Daniels MC, Schurr JR, Kolls JK and Scott DK . (2003). J. Biol. Chem., 278, 6588–6595.

  • Duncan R and Hershey JW . (1983). J. Biol. Chem., 258, 7228–7235.

  • Duncan R and Hershey JW . (1985). J. Biol. Chem., 260, 5486–5492.

  • Eilers M, Picard D, Yamamoto KR and Bishop JM . (1989). Nature, 340, 66–68.

  • Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Greene J, Cocito A and Amati B . (2003). Genes. Dev., 17, 1115–1129.

  • Gallant P, Shiio Y, Cheng PF, Parkhurst SM and Eisenman RN . (1996). Science, 274, 1523–1527.

  • Gomez-Roman N, Grandori C, Eisenman RN and White RJ . (2003). Nature, 421, 290–294.

  • Greasley PJ, Bonnard C and Amati B . (2000). Nucleic. Acids. Res., 28, 446–453.

  • Haggerty TJ, Zeller KI, Osthus RC, Wonsey DR and Dang CV . (2003). Proc. Natl. Acad. Sci. USA, 100, 5313–5318.

  • Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW and Weinberg RA . (1999). Nature, 400, 464–468.

  • Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA and Weinberg RA . (2002). Mol. Cell. Biol., 22, 2111–2123.

  • Hanahan D and Weinberg RA . (2000). Cell, 100, 57–70.

  • Hahn WC and Weinberg RA . (2002). N. Engl. J. Med., 347, 1593–1603.

  • Hanic-Joyce PJ, Johnston GC and Singer RA . (1987). Exp. Cell. Res., 172, 134–145.

  • Hartwell LH and Unger MW . (1977). J. Cell Biol., 75, 422–435.

  • Hidalgo M and Rowinsky EK . (2000). Oncogene, 19, 6680–6686.

  • Iritani BM and Eisenman RN . (1999). Proc. Natl. Acad. Sci. USA, 96, 13180–13185.

  • Iversen OH, Iversen U, Ziegler JL and Bluming AZ . (1974). Eur. J. Cancer, 10, 155–163.

  • Johnston GC, Pringle JR and Hartwell LH . (1977). Exp. Cell Res., 105, 79–98.

  • Johnston LA, Prober DA, Edgar BA, Eisenman RN and Gallant P . (1999). Cell, 98, 779–790.

  • Jones RM, Branda J, Johnston KA, Polymenis M, Gadd M, Rustgi A, Callanan L and Schmidt EV . (1996). Mol. Cell. Biol., 16, 4754–4764.

  • Killander D and Zetterberg A . (1965). Exp. Cell. Res., 40, 12–20.

  • Kim S, Li Q, Dang CV and Lee LA . (2000). Proc. Natl. Acad. Sci. USA, 97, 11198–11202.

  • Kozak M . (1991). J. Cell Biol., 115, 887–903.

  • Kretzner L, Blackwood EM and Eisenman RN . (1992a). Nature, 359, 426–429.

  • Kretzner L, Blackwood EM and Eisenman RN . (1992b). Curr. Top. Microbiol. Immunol., 182, 435–443.

  • Lazaris-Karatzas A, Montine KS and Sonenberg N . (1990). Nature, 345, 544–547.

  • Lewis BC, Prescott JE, Campbell SE, Shim H, Orlowski RZ and Dang CV . (2000). Cancer Res., 60, 6178–6183.

  • Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N and Lawrence Jr JC . (1994). Science, 266, 653–656.

  • Lynch M, Fitzgerald C, Johnston KA, Wang S and Schmidt EV . (2004). J. Biol. Chem., 279, 3327–3339.

  • Mateyak MK, Obaya AJ, Adachi S and Sedivy JM . (1997). Cell. Growth Differ., 8, 1039–1048.

  • Matthews MB, Sonenberg N and Hershey JWB . (2000). Translational Control of Gene Expression, Sonenberg N, Hershey JWB and Mathews M (eds) Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, pp 1020.

    Google Scholar 

  • Nelsen CJ, Rickheim DG, Tucker MM, Hansen LK and Albrecht JH . (2003). J. Biol. Chem., 278, 3656–3663.

  • Nikiforov MA, Chandriani S, O'Connell B, Petrenko O, Kotenko I, Beavis A, Sedivy JM and Cole MD . (2002). Mol. Cell. Biol., 22, 5793–5800.

  • Orian A, van Steensel B, Delrow J, Bussemaker HJ, Li L, Sawado T, Williams E, Loo LW, Cowley SM, Yost C, Pierce S, Edgar BA, Parkhurst SM and Eisenman RN . (2003). Genes. Dev., 17, 1101–1114.

  • Osthus RC, Shim H, Kim S, Li Q, Reddy R, Mukherjee M, Xu Y, Wonsey D, Lee LA and Dang CV . (2000). J. Biol. Chem., 275, 21797–21800.

  • Packham G and Cleveland JL . (1994). Mol. Cell. Biol., 14, 5741–5747.

  • Pena A, Reddy CD, Wu S, Hickok NJ, Reddy EP, Yumet G, Soprano DR and Soprano KJ . (1993). J. Biol. Chem., 268, 27277–27285.

  • Polymenis M and Schmidt EV . (1997). Genes Dev., 11, 2522–2531.

  • Polymenis M and Schmidt EV . (1999). Curr. Opin. Genet. Dev., 9, 76–80.

  • Pyronnet S, Vagner S, Bouisson M, Prats AC, Vaysse N and Pradayrol L . (1996). Cancer Res., 56, 1742–1745.

  • Rosenwald IB . (1996). Cancer Lett., 102, 113–123.

  • Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV, Sonenberg N and London IM . (1995). J. Biol. Chem., 270, 21176–21180.

  • Rosenwald IB, Lazaris-Karatzas A, Sonenberg N and Schmidt EV . (1993a). Mol. Cell. Biol., 13, 7358–7363.

  • Rosenwald IB, Rhoads DB, Callanan LD, Isselbacher KJ and Schmidt EV . (1993b). Proc. Natl. Acad. Sci. USA, 90, 6175–6178.

  • Rousseau D, Kaspar R, Rosenwald I, Gehrke L and Sonenberg N . (1996). Proc. Natl. Acad. Sci. USA, 93, 1065–1070.

  • Schmidt EV . (1999). Oncogene, 18, 2988–2996.

  • Shim H, Chun YS, Lewis BC and Dang CV . (1998). Proc. Natl. Acad. Sci. USA, 95, 1511–1516.

  • Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, Dalla-Favera R and Dang CV . (1997). Proc. Natl. Acad. Sci. USA, 94, 6658–6663.

  • Tobias KE, Shor J and Kahana C . (1995). Oncogene, 11, 1721–1727.

  • Trumpp A, Refaeli Y, Oskarsson T, Gasser S, Murphy M, Martin GR and Bishop JM . (2001). Nature, 414, 768–773.

  • Valera A, Pujol A, Gregori X, Riu E, Visa J and Bosch F . (1995). FASEB J., 9, 1067–1078.

  • Wagner AJ, Meyers C, Laimins LA and Hay N . (1993). Cell Growth Differ., 4, 879–883.

  • Watson JD, Oster SK, Shago M, Khosravi F and Penn LZ . (2002). J. Biol. Chem., 277, 36921–36930.

  • Wonsey DR, Zeller KI and Dang CV . (2002). Proc. Natl. Acad. Sci. USA, 99, 6649–6654.

  • Wu KJ, Polack A and Dalla-Favera R . (1999). Science, 283, 676–679.

  • Zeller KI, Haggerty TJ, Barrett JF, Guo Q, Wonsey DR and Dang CV . (2001). J. Biol. Chem., 276, 48285–48291.

  • Zeller KI, Jegga AG, Aronow BJ, O'Donnell KA and Dang CV . (2003). Genome Biol., 4, R69.

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Acknowledgements

This work was supported by a grant from the National Cancer Institute of the National Institutes of Health, RO1-CA63117.

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  1. Cancer Research Center at Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA

    Emmett V Schmidt

  2. MassGeneral Hospital for Children, 55 Fruit Street

    Emmett V Schmidt

  3. Boston, MA, 02114, USA

    Emmett V Schmidt

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Schmidt, E. The role of c-myc in regulation of translation initiation. Oncogene 23, 3217–3221 (2004). https://doi.org/10.1038/sj.onc.1207548

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