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Role of AIF in caspase-dependent and caspase-independent cell death

Oncogene volume 23, pages 2785–2796 (2004)Cite this article

Abstract

The major challenge in treating cancer is that many tumor cells carry mutations in key apoptotic genes such as p53, Bcl family proteins or those affecting caspase signaling. Such defects render treatment with traditional chemotherapeutic agents ineffective. Many studies have demonstrated the importance of caspase-independent cell death pathways in injury, degenerative diseases and tumor tissue. It is now recognized that in addition to their critical role in the production of cellular energy, mitochondria are also the source of key proapoptotic molecules involved in caspase activation. More recently, it has been discovered that in response to apoptotic stimuli, mitochondria can also release caspase-independent cell death effectors such as AIF and Endonuclease G. In this review, we examine the role of Bcl family proteins and poly(ADP-ribose) polymerase-1 signaling in the regulation of these apoptotic pathways and address the ongoing controversies in this field. Continued study of the mechanisms of apoptosis including caspase-independent death processes are likely to reveal novel therapeutic targets for the treatment of diverse human pathologies including cancer, neurodegenerative diseases and acute injuries such as stroke or myocardial infarction.

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Acknowledgements

We are indebted to David S Park, Eric Cheung and Jason MacLaurin for critical reading of the manuscript. SPC was supported by a CIHR Postdoctoral Fellowship. This work was supported by grants from CIHR, Canadian Stroke Network and Heart and Stroke Foundation of Canada to RSS and grants from the NIH (NS39148), the Robert Packard Center for ALS Research at Johns Hopkins Medical Institutions, the American Heart Association and the Mary Lou McIlhaney Scholar Award to VLD Under an agreement between the Johns Hopkins University and Guilford Pharmaceuticals, TMD and VLD are entitled to a share of sales royalty received by the university from Guilford. The terms of this arrangement are being managed by the university in accordance with its conflict of interest policies.

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  1. Department of Cellular and Molecular Medicine, Ottawa Health Research Institute, University of Ottawa, 451 Smyth Rd., Ottawa, K1H 8M5, Canada

    Sean P Cregan & Ruth S Slack

  2. Department of Neurology, Neuroscience, and Physiology, Institute for Cell Engineering, Johns Hopkins University, 733 North Broadway, #731, Baltimore, 21205, MD, USA

    Valina L Dawson

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Cregan, S., Dawson, V. & Slack, R. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 23, 2785–2796 (2004). https://doi.org/10.1038/sj.onc.1207517

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