Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Report
  • Published:

Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Oncogene volume 23, pages 1950–1953 (2004)Cite this article

Abstract

Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  • Berns EM, Klijn JG, van Putten WL, van Staveren IL, Portengen H and Foekens JA . (1992). Cancer Res., 52, 1107–1113.

  • Birrer MJ, Segal S, DeGreve JS, Kaye F, Sausville EA and Minna JD . (1988). Mol. Cell. Biol., 8, 2668–2673.

  • Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC and Basset P . (1995). Cancer Res., 55, 2896–2903.

  • Deininger MW, Goldman JM, Lydon N and Melo JV . (1997). Blood, 90, 3691–3698.

  • Dickson C, Creer A and Fantl V . (2000). Oncogene, 19, 1097–1101.

  • Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M and Beach D . (1995). Science, 269, 1575–1577.

  • Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA and Ruddle FH . (1980). Proc. Natl. Acad. Sci. USA, 77, 7380–7384.

  • Kim J, Cha JH, Tisher CC and Madsen KM . (1996). Am. J. Physiol. Renal Physiol., 270, F575–F592.

  • Ko J, Lee YH, Hwang SY, Lee YS, Shin SM, Hwang JH, Kim J, Kim YW, Jang S-W, Ryoo ZY, Kim I-K, Namkoong SE and Kim JW . (2003). Oncogene, 22, 4679–4689.

  • Land H, Parada LF and Weinberg RA . (1983). Nature, 304, 596–602.

  • Miki T, Matsui T, Heidaran MA and Aaronson SA . (1989). Gene, 83, 137–146.

  • Nebert DW . (1991). Mutat. Res., 247, 267–281.

  • Nowell P . (1976). Science, 194, 23–28.

  • Ottenhoff-Kalff AE, Rijksen G, van Beurden EA, Hennipman A, Michels AA and Staal GE . (1992). Cancer Res., 52, 4773–4778.

  • Proux V, Provot S, Felder-Schmittbuhl MP, Laugier D, Calothy G and Marx M . (1996). J. Biol. Chem., 271, 30790–30797.

  • Sambrook J, Fritsch EF and Maniatis T . (1989). Molecular Cloning: A Laboratory Manual, 2nd edn. Maniatis T (ed). Cold Spring Harbor Laboratory: New York.

    Google Scholar 

  • Schuuring E, Verhoeven E, van Tinteren H, Peterse JL, Nunnink B, Thunnissen FB, Devilee P, Cornelisse CJ, van de Vijver MJ and Mooi WJ . (1992). Cancer Res., 52, 5229–5234.

  • Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A and Press MF . (1989). Science, 244, 707–712.

  • Smith JB and Wickstrom E . (1998). J. Natl. Cancer Inst., 90, 1146–1154.

Download references

Author information

Authors and Affiliations

  1. Asan Institute for Life Sciences and Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, 138-736, Korea

    Jesang Ko

  2. Molecular Genetic Laboratory and Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, 137-040, Korea

    Seung Min Shin, Young Mi Oh & Jin Woo Kim

  3. Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, 137-040, Korea

    Youn Soo Lee

  4. Laboratory of Animal Science, College of Medicine, The Catholic University of Korea, Seoul, 137-040, Korea

    Zae Yoong Ryoo

  5. Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, 705-717, Korea

    Young Han Lee

  6. Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, 138-736, Korea

    Doe Sun Na

Authors
  1. Jesang Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seung Min Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Young Mi Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Youn Soo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zae Yoong Ryoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Young Han Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Doe Sun Na
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jin Woo Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jin Woo Kim.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ko, J., Shin, S., Oh, Y. et al. Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice. Oncogene 23, 1950–1953 (2004). https://doi.org/10.1038/sj.onc.1207356

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1207356

Keywords

This article is cited by

Search

Advanced search

Quick links