Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

A decade of caspases

Oncogene volume 22, pages 8543–8567 (2003)Cite this article

Abstract

Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and pathological processes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

Similar content being viewed by others

References

  • Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X and Akey CW . (2002). Mol. Cell, 9, 423–432.

  • Ahmad M, Srinivasula SM, Hegde R, Mukattash R, Fernandes-Alnemri T and Alnemri ES . (1998). Cancer Res., 58, 5201–5205.

  • Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T and Alnemri ES . (1997). Cancer Res., 57, 615–619.

  • Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW and Yuan J . (1996). Cell, 87, 171.

  • An B and Dou QP . (1996). Cancer Res., 56, 438–442.

  • Bachelder RE, Ribick MJ, Marchetti A, Falcioni R, Soddu S, Davis KR and Mercurio AM . (1999). J. Cell. Biol., 147, 1063–1072.

  • Bachelder RE, Wendt MA, Fujita N, Tsuruo T and Mercurio AM . (2001). J. Biol. Chem., 276, 34702–34707.

  • Baliga BC, Colussi PA, Read SH, Dias MM, Jans DA and Kumar S . (2002). J. Biol. Chem., 10, 10.

  • Barrett AJ and Rawlings ND . (2001). Biol. Chem., 382, 727–733.

  • Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JC, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL and Yuan J . (1998). Genes Dev., 12, 1304–1314.

  • Bernstein C, Bernstein H, Payne CM and Garewal H . (2002). Mutat. Res., 511, 145–178.

  • Bilsland J, Roy S, Xanthoudakis S, Nicholson DW, Han Y, Grimm E, Hefti F and Harper SJ . (2002). J. Neurosci., 22, 2637–2649.

  • Blanchard H, Kodandapani L, Mittl PR, Marco SD, Krebs JF, Wu JC, Tomaselli KJ and Grutter MG . (1999). Struct. Fold Des., 7, 1125–1133.

  • Bodmer JL, Holler N, Reynard S, Vinciguerra P, Schneider P, Juo P, Blenis J and Tschopp J . (2000). Nat. Cell Biol., 2, 241–243.

  • Bossy-Wetzel E, Newmeyer DD and Green DR . (1998). EMBO J., 17, 37–49.

  • Brancolini C, Sgorbissa A and Schneider C . (1998). Cell Death Differ., 5, 1042–1050.

  • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME . (1999). Cell, 96, 857–868.

  • Buckley CD, Pilling D, Henriquez NV, Parsonage G, Threlfall K, Scheel-Toellner D, Simmons DL, Akbar AN, Lord JM and Salmon M . (1999). Nature, 397, 534–539.

  • Budihardjo I, Oliver H, Lutter M, Luo X and Wang X . (1999). Annu. Rev. Cell Dev. Biol., 15, 269–290.

  • Bump NJ, Hackett M, Hugunin M, Seshagiri S, Brady K, Chen P, Ferenz C, Franklin S, Ghayur T and Li P, Licari J, Mankovicn L, Shi L, Greenberg AH, Miller K and Wong WW . (1995). Science, 269, 1885–1888.

  • Cain K, Bratton SB, Langlais C, Walker G, Brown DG, Sun XM and Cohen GM . (2000). J. Biol. Chem., 275, 6067–6070.

  • Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S and Reed JC . (1998). Science, 282, 1318–1321.

  • Casciola-Rosen LA, Anhalt GJ and Rosen A . (1995). J. Exp. Med., 182, 1625–1634.

  • Casciola-Rosen LA, Miller DK, Anhalt GJ and Rosen A . (1994). J. Biol. Chem., 269, 30757–30760.

  • Casiano CA, Martin SJ, Green DR and Tan EM . (1996). J. Exp. Med., 184, 765–770.

  • Caulin C, Salvesen GS and Oshima RG . (1997). J. Cell. Biol., 138, 1379–1394.

  • Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, Huebner K and Black RA . (1992). Science, 256, 97–100.

  • Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES and Shi Y . (2001). Cell, 107, 399–407.

  • Chan SL, Griffin WS and Mattson MP . (1999). J. Neurosci. Res., 57, 315–323.

  • Chang DW, Xing Z, Pan Y, Algeciras-Schimnich A, Barnhart BC, Yaish-Ohad S, Peter ME and Yang X . (2002). EMBO J., 21, 3704–3714.

  • Chautan M, Chazal G, Cecconi F, Gruss P and Golstein P . (1999). Curr. Biol., 9, 967–970.

  • Chen Y and Lai MZ . (2001). J. Biol. Chem., 276, 8350–8357.

  • Cheng EH, Kirsch DG, Clem RJ, Ravi R, Kastan MB, Bedi A, Ueno K and Hardwick JM . (1997). Science, 278, 1966–1968.

  • Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE and Lenardo MJ . (2002). Nature, 419, 395–399.

  • Clark RS, Kochanek PM, Chen M, Watkins SC, Marion DW, Chen J, Hamilton RL, Loeffert JE and Graham SH . (1999). FASEB J., 13, 813–821.

  • Clem RJ, Cheng EH, Karp CL, Kirsch DG, Ueno K, Takahashi A, Kastan MB, Griffin DE, Earnshaw WC, Veliuona MA and Hardwick JM . (1998). Proc. Natl. Acad. Sci. USA, 95, 554–559.

  • Clem RJ, Fechheimer M and Miller LK . (1991). Science, 254, 1388–1390.

  • Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A and Olson MF . (2001). Nat. Cell Biol., 3, 339–345.

  • Colussi PA, Harvey NL and Kumar S . (1998). J. Biol. Chem., 273, 24535–24542.

  • Cowling V and Downward J . (2002). Cell Death Differ., 9, 1046–1056.

  • Crook NE, Clem RJ and Miller LK . (1993). J. Virol., 67, 2168–2174.

  • Crouch DH, Fincham VJ and Frame MC . (1996). Oncogene, 12, 2689–2696.

  • Cryns V and Yuan J . (1998). Genes Dev., 12, 1551–1570.

  • Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, Parker PJ, Kirschner MW and Yuan J . (1997). J. Biol. Chem., 272, 29449–29453.

  • Darmon AJ, Nicholson DW and Bleackley RC . (1995). Nature, 377, 446–448.

  • Datta R, Kojima H, Banach D, Bump NJ, Talanian RV, Alnemri ES, Weichselbaum RR, Wong WW and Kufe DW . (1997a). J. Biol. Chem., 272, 1965–1969.

  • Datta R, Kojima H, Yoshida K and Kufe D . (1997b). J. Biol. Chem., 272, 20317–20320.

  • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME . (1997c). Cell, 91, 231–241.

  • de Martin R, Schmid JA and Hofer-Warbinek R . (1999). Mutat. Res., 437, 231–243.

  • Deaciuc IV, D'Souza NB, de Villiers WJ, Burikhanov R, Sarphie TG, Hill DB and McClain CJ . (2001). Alcohol Clin. Exp. Res., 25, 935–943.

  • Deak JC, Cross JV, Lewis M, Qian Y, Parrott LA, Distelhorst CW and Templeton DJ . (1998). Proc. Natl. Acad. Sci. USA, 95, 5595–5600.

  • del Peso L, Gonzalez-Garcia M, Page C, Herrera R and Nunez G . (1997). Science, 278, 687–689.

  • Deshmukh M, Kuida K and Johnson Jr EM . (2000). J. Cell. Biol., 150, 131–143.

  • Dolle RE, Hoyer D, Prasad CV, Schmidt SJ, Helaszek CT, Miller RE and Ator MA . (1994). J. Med. Chem., 37, 563–564.

  • Dolle RE, Singh J, Whipple D, Osifo IK, Speier G, Graybill TL, Gregory JS, Harris AL, Helaszek CT, Miller RE and Ator MA . (1995). J. Med. Chem., 38, 220–222.

  • Duan H and Dixit VM . (1997). Nature, 385, 86–89.

  • Earnshaw WC, Martins LM and Kaufmann SH . (1999). Annu. Rev. Biochem., 68, 383–424.

  • Eckhart L, Ban J, Fischer H and Tschachler E . (2000a). Biochem. Biophys. Res. Commun., 277, 655–659.

  • Eckhart L, Declercq W, Ban J, Rendl M, Lengauer B, Mayer C, Lippens S, Vandenabeele P and Tschachler E . (2000b). J. Invest. Dermatol., 115, 1148–1151.

  • Eddins MJ, Lemongello D, Friesen PD and Fisher AJ . (2002). Acta Crystallogr. D: Biol. Crystallogr., 58, 299–302.

  • Ekert PG, Silke J and Vaux DL . (1999a). Cell Death Differ., 6, 1081–1086.

  • Ekert PG, Silke J and Vaux DL . (1999b). EMBO J., 18, 330–338.

  • Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR and Bredesen DE . (1999a). J. Biol. Chem., 274, 8730–8736.

  • Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR and Bredesen DE . (1999b). J. Neurochem., 72, 185–195.

  • Ellis HM and Horvitz HR . (1986). Cell, 44, 817–829.

  • Emoto Y, Manome Y, Meinhardt G, Kisaki H, Kharbanda S, Robertson M, Ghayur T, Wong WW, Kamen R and Weichselbaum R . (1995). EMBO J., 14, 6148–6156.

  • Enari M, Hug H and Nagata S . (1995). Nature, 375, 78–81.

  • Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A and Nagata S . (1998). Nature, 391, 43–50.

  • Endo K, Oki E, Biedermann V, Kojima H, Yoshida K, Johannes FJ, Kufe D and Datta R . (2000). J. Biol. Chem., 275, 18476–18481.

  • Estrov Z, Black RA, Sleath PR, Harris D, Van Q, LaPushin R, Estey EH and Talpaz M . (1995). Blood, 86, 4594–4602.

  • Fernando P, Kelly JF, Balazsi K, Slack RS and Megeney LA . (2002). Proc. Natl. Acad. Sci. USA, 99, 11025–11030.

  • Fischer H, Koenig U, Eckhart L and Tschachler E . (2002). Biochem. Biophys. Res. Commun., 293, 722–726.

  • Fisher AJ, Cruz W, Zoog SJ, Schneider CL and Friesen PD . (1999). EMBO J., 18, 2031–2039.

  • Flygare J, Armstrong RC, Wennborg A, Orsan S and Hellgren D . (1998). FEBS Lett., 427, 247–251.

  • Foo SY and Nolan GP . (1999). Trends Genet., 15, 229–235.

  • Friedlander RM, Brown RH, Gagliardini V, Wang J and Yuan J . (1997a). Nature, 388, 31.

  • Friedlander RM, Gagliardini V, Hara H, Fink KB, Li W, MacDonald G, Fishman MC, Greenberg AH, Moskowitz MA and Yuan J . (1997b). J. Exp. Med., 185, 933–940.

  • Fujita E, Jinbo A, Matuzaki H, Konishi H, Kikkawa U and Momoi T . (1999). Biochem. Biophys. Res. Commun., 264, 550–555.

  • Gagliardini V, Fernandez PA, Lee RK, Drexler HC, Rotello RJ, Fishman MC and Yuan J . (1994). Science, 263, 826–828.

  • Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW and Thornberry NA . (1998). J. Biol. Chem., 273, 32608–32613.

  • Gervais FG, Thornberry NA, Ruffolo SC, Nicholson DW and Roy S . (1998). J. Biol. Chem., 273, 17102–17108.

  • Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S and Nicholson DW . (1999). Cell, 97, 395–406.

  • Ghayur T, Banerjee S, Hugunin M, Butler D, Herzog L, Carter A, Quintal L, Sekut L, Talanian R, Paskind M, Wong W, Kamen R, Tracey D and Allen H . (1997). Nature, 386, 619–623.

  • Ghayur T, Hugunin M, Talanian RV, Ratnofsky S, Quinlan C, Emoto Y, Pandey P, Datta R, Huang Y, Kharbanda S, Allen H, Kamen R, Wong W and Kufe D . (1996). J. Exp. Med., 184, 2399–2404.

  • Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK, Bromm M, Kazemi-Esfarjani P, Thornberry NA, Vaillancourt JP and Hayden MR . (1996). Nat. Genet., 13, 442–449.

  • Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA and Krebs EG . (1998). EMBO J., 17, 2224–2234.

  • Graybill TL, Dolle RE, Helaszek CT, Miller RE and Ator MA . (1994). Int. J. Pept. Protein Res., 44, 173–182.

  • Greidinger EL, Miller DK, Yamin TT, Casciola-Rosen L and Rosen A . (1996). FEBS Lett., 390, 299–303.

  • Grobmyer SR, Armstrong RC, Nicholson SC, Gabay C, Arend WP, Potter SH, Melchior M, Fritz LC and Nathan CF . (1999). Mol. Med., 5, 585–594.

  • Gross A, McDonnell JM and Korsmeyer SJ . (1999). Genes Dev., 13, 1899–1911.

  • Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T and Alnemri ES . (2002). J. Biol. Chem., 277, 13430–13437.

  • Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM and Mak TW . (1998). Cell, 94, 339–352.

  • Han BH, Xu D, Choi J, Han Y, Xanthoudakis S, Roy S, Tam J, Vaillancourt J, Colucci J, Siman R, Giroux A, Robertson GS, Zamboni R, Nicholson DW and Holtzman DM . (2002). J. Biol. Chem., 277, 30128–30136.

  • Hara H, Fink K, Endres M, Friedlander RM, Gagliardini V, Yuan J and Moskowitz MA . (1997). J. Cereb. Blood Flow Metab., 17, 370–375.

  • Haraguchi M, Torii S, Matsuzawa S, Xie Z, Kitada S, Krajewski S, Yoshida H, Mak TW and Reed JC . (2000). J. Exp. Med., 191, 1709–1720.

  • Hartmann A, Hunot S, Michel PP, Muriel MP, Vyas S, Faucheux BA, Mouatt-Prigent A, Turmel H, Srinivasan A, Ruberg M, Evan GI, Agid Y and Hirsch EC . (2000). Proc. Natl. Acad. Sci. USA, 97, 2875–2880.

  • Harvey NL, Butt AJ and Kumar S . (1997). J. Biol. Chem., 272, 13134–13139.

  • Haviv R, Lindenboim L, Yuan J and Stein R . (1998). J. Neurosci. Res., 52, 491–497.

  • Hayashi Y, Yayagi K and Haneji N . (2000). Arch. Immunol. Ther. Exp. (Warsz), 48, 399–403.

  • Hengartner MO, Ellis RE and Horvitz HR . (1992). Nature, 356, 494–499.

  • Hengartner MO and Horvitz HR . (1994). Cell, 76, 665–676.

  • Henshall DC, Clark RS, Adelson PD, Chen M, Watkins SC and Simon RP . (2000). Neurology, 55, 250–257.

  • Hirata H, Takahashi A, Kobayashi S, Yonehara S, Sawai H, Okazaki T, Yamamoto K and Sasada M . (1998). J. Exp. Med., 187, 587–600.

  • Hoglen NC, Hirakawa BP, Fisher CD, Weeks S, Srinivasan A, Wong AM, Valentino KL, Tomaselli KJ, Bai X, Karanewsky DS and Contreras PC . (2001). J. Pharmacol. Exp. Ther., 297, 811–818.

  • Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B and Tschopp J . (2000). Nat. Immunol., 1, 489–495.

  • Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ, Klender P, Xanthoudakis S, Roy S, Black C, Grimm E, Aspiotis R, Han Y, Nicholson DW and Karl IE . (2000). Nat. Immunol., 1, 496–501.

  • Hotti A, Jarvinen K, Siivola P and Holtta E . (2000). Oncogene, 19, 2354–2362.

  • Hu S, Snipas SJ, Vincenz C, Salvesen G and Dixit VM . (1998). J. Biol. Chem., 273, 29648–29653.

  • Hunter CP . (1999). Curr. Biol., 9, R440–R442.

  • Inohara N, Koseki T, Chen S, Benedict MA and Nunez G . (1999). J. Biol. Chem., 274, 270–274.

  • Inoue H, Tsubota K, Ono M, Kizu Y, Mizuno F, Takada K, Yamada K, Yanagi K, Hayashi Y and Saito I . (2001). J. Immunol., 166, 5801–5809.

  • Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE and Tschopp J . (1997). Nature, 388, 190–195.

  • Janicke RU, Walker PA, Lin XY and Porter AG . (1996). EMBO J., 15, 6969–6978.

  • Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC and DeAizpurua HJ . (2000). Oncogene, 19, 4290–4297.

  • Juo P, Kuo CJ, Yuan J and Blenis J . (1998). Curr. Biol., 8, 1001–1008.

  • Kabra NH, Kang C, Hsing LC, Zhang J and Winoto A . (2001). Proc. Natl. Acad. Sci. USA, 98, 6307–6312.

  • Kang SJ, Wang S, Hara H, Peterson EP, Namura S, Amin-Hanjani S, Huang Z, Srinivasan A, Tomaselli KJ, Thornberry NA, Moskowitz MA and Yuan J . (2000). J. Cell. Biol., 149, 613–622.

  • Kang SJ, Wang S, Kuida K and Yuan J . (2002). Cell Death Differ., 9, 1115–1125.

  • Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE and Poirier GG . (1993). Cancer Res., 53, 3976–3985.

  • Kawahara A, Ohsawa Y, Matsumura H, Uchiyama Y and Nagata S . (1998). J. Cell. Biol., 143, 1353–1360.

  • Kim PK, Mahidhara R and Seol DW . (2001). Drug Resist. Updat., 4, 293–296.

  • Kim SJ, Ju JW, Oh CD, Yoon YM, Song WK, Kim JH, Yoo YJ, Bang OS, Kang SS and Chun JS . (2002). J. Biol. Chem., 277, 1332–1339.

  • Kirchhoff S, Muller WW, Li-Weber M and Krammer PH . (2000). Eur. J. Immunol., 30, 2765–2774.

  • Kischkel FC, Lawrence DA, Tinel A, LeBlanc H, Virmani A, Schow P, Gazdar A, Blenis J, Arnott D and Ashkenazi A . (2001). J. Biol. Chem., 276, 46639–46646.

  • Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD . (1997). Science, 275, 1132–1136.

  • Koenig U, Eckhart L and Tschachler E . (2001). Biochem. Biophys. Res. Commun., 285, 1150–1154.

  • Komiyama T, Ray CA, Pickup DJ, Howard AD, Thornberry NA, Peterson EP and Salvesen G . (1994). J. Biol. Chem., 269, 19331–19337.

  • Konishi Y, Lehtinen M, Donovan N and Bonni A . (2002). Mol. Cell, 9, 1005–1016.

  • Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ and Schlesinger PH . (2000). Cell Death Differ., 7, 1166–1173.

  • Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ and Williams LT . (1997). Science, 278, 294–298.

  • Krueger A, Schmitz I, Baumann S, Krammer PH and Kirchhoff S . (2001). J. Biol. Chem., 276, 20633–20640.

  • Ku NO, Liao J and Omary MB . (1997). J. Biol. Chem., 272, 33197–33203.

  • Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P and Flavell RA . (1998). Cell, 94, 325–337.

  • Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS and Flavell RA . (1995). Science, 267, 2000–2003.

  • Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P and Flavell RA . (1996). Nature, 384, 368–372.

  • Kulms D, Dussmann H, Poppelmann B, Stander S, Schwarz A and Schwarz T . (2002). Cell Death Differ., 9, 598–608.

  • LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC and Jay G . (1995). Nat. Genet., 9, 21–30.

  • Lamkanfi M, Declercq W, Kalai M, Saelens X and Vandenabeele P . (2002). Cell Death Differ., 9, 358–361.

  • Lassus P, Opitz-Araya X and Lazebnik Y . (2002). Science, 297, 1352–1354.

  • Lazebnik YA, Takahashi A, Poirier GG, Kaufmann SH and Earnshaw WC . (1995). J. Cell Sci., 19 (Suppl.), 41–49.

  • Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA and Moskowitz MA . (2002). Proc. Natl. Acad. Sci. USA, 99, 15188–15193.

  • LeBlanc A, Liu H, Goodyer C, Bergeron C and Hammond J . (1999). J. Biol. Chem., 274, 23426–23436.

  • Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, Kikly K, Winkler JD, Sung CM, Debouck C, Richardson S, Levy MA, DeWolf Jr WE, Keller PM, Tomaszek T, Head MS, Ryan MD, Haltiwanger RC, Liang PH, Janson CA, McDevitt PJ, Johanson K, Concha NO, Chan W, Abdel-Meguid SS, Badger AM, Lark MW, Nadeau DP, Suva LJ, Gowen M and Nuttall ME . (2000). J. Biol. Chem., 275, 16007–16014.

  • Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM and Peter ME . (2002). J. Cell. Biol., 158, 1051–1066.

  • Lee KK, Murakawa M, Nishida E, Tsubuki S, Kawashima S, Sakamaki K and Yonehara S . (1998). Oncogene, 16, 3029–3037.

  • Lees-Miller SP . (1996). Biochem. Cell Biol., 74, 503–512.

  • Leist M, Single B, Castoldi AF, Kuhnle S and Nicotera P . (1997). J. Exp. Med., 185, 1481–1486.

  • Leonard JR, Klocke BJ, D'Sa C, Flavell RA and Roth KA . (2002). J. Neuropathol. Exp. Neurol., 61, 673–677.

  • Levkau B, Koyama H, Raines EW, Clurman BE, Herren B, Orth K, Roberts JM and Ross R . (1998). Mol. Cell, 1, 553–563.

  • Levkau B, Scatena M, Giachelli CM, Ross R and Raines EW . (1999). Nat. Cell Biol., 1, 227–233.

  • Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A and Yuan J . (1997a). J. Biol. Chem., 272, 21010–21017.

  • Li H and Yuan J . (1999). Curr. Opin. Cell Biol., 11, 261–266.

  • Li H, Zhu H, Xu CJ and Yuan J . (1998). Cell, 94, 491–501.

  • Li J, Billiar TR, Talanian RV and Kim YM . (1997b). Biochem. Biophys. Res. Commun., 240, 419–424.

  • Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wei F-Y, Wong W, Kamen R and Seshadri T . (1995). Cell, 80, 401–411.

  • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES and Wang X . (1997c). Cell, 91, 479–489.

  • Lin XY, Choi MS and Porter AG . (2000). J. Biol. Chem., 275, 39920–39926.

  • Lin Y, Devin A, Rodriguez Y and Liu ZG . (1999). Genes Dev., 13, 2514–2526.

  • Lippens S, Kockx M, Knaapen M, Mortier L, Polakowska R, Verheyen A, Garmyn M, Zwijsen A, Formstecher P, Huylebroeck D, Vandenabeele P and Declercq W . (2000). Cell Death Differ., 7, 1218–1224.

  • Liu B, Peng D, Lu Y, Jin W and Fan Z . (2002). J. Biol. Chem., 277, 30159–30164.

  • Liu X, Kim CN, Yang J, Jemmerson R and Wang X . (1996). Cell, 86, 147–157.

  • Liu X, Zou H, Slaughter C and Wang X . (1997). Cell, 89, 175–184.

  • Livingston DJ . (1997). J. Cell. Biochem., 64, 19–26.

  • Lockshin RA . (1969). J. Insect Physiol., 15, 1505–1516.

  • Lockshin RA and Williams CM . (1965). J. Insect Physiol., 11, 803–809.

  • Los M, Van de Craen M, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Droge W, Krammer PH, Fiers W and Schulze-Osthoff K . (1995). Nature, 375, 81–83.

  • Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P and Wagner G . (1999). Cell, 99, 747–755.

  • Luo X, Budihardjo I, Zou H, Slaughter C and Wang X . (1998). Cell, 94, 481–490.

  • Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA and Rosen A . (2000). J. Cell. Biol., 149, 603–612.

  • Margolin N, Raybuck SA, Wilson KP, Chen W, Fox T, Gu Y and Livingston DJ . (1997). J. Biol. Chem., 272, 7223–7228.

  • Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K, Tomaselli KJ, Roy S, Nicholson DW, Vaux DL, Bouillet P, Adams JM and Strasser A . (2002). Nature, 419, 634–637.

  • Martinon F, Burns K and Tschopp J . (2002). Mol. Cell, 10, 417–426.

  • Martinon F, Holler N, Richard C and Tschopp J . (2000). FEBS Lett., 468, 134–136.

  • Matsumura H, Shimizu Y, Ohsawa Y, Kawahara A, Uchiyama Y and Nagata S . (2000). J. Cell. Biol., 151, 1247–1256.

  • Matsushita K, Wu Y, Qiu J, Lang-Lazdunski L, Hirt L, Waeber C, Hyman BT, Yuan J and Moskowitz MA . (2000). J. Neurosci., 20, 6879–6887.

  • Matsuyama S, Llopis J, Deveraux QL, Tsien RY and Reed JC . (2000). Nat. Cell Biol., 2, 318–325.

  • Micheau O, Solary E, Hammann A and Dimanche-Boitrel MT . (1999). J. Biol. Chem., 274, 7987–7992.

  • Micheau O, Thome M, Schneider P, Holler N, Tschopp J, Nicholson D, Briand C and Grutter MG . (2002). J. Biol. Chem., 4, 4.

  • Mittl PR, Di Marco S, Krebs JF, Bai X, Karanewsky DS, Priestle JP, Tomaselli KJ and Grutter MG . (1997). J. Biol. Chem., 272, 6539–6547.

  • Miura M, Friedlander RM and Yuan J . (1995). Proc. Natl. Acad. Sci. USA, 92, 8318–8322.

  • Miura M, Zhu H, Rotello R, Hartwieg EA and Yuan J . (1993). Cell, 75, 653–660.

  • Mohr S, Zech B, Lapetina EG and Brune B . (1997). Biochem. Biophys. Res. Commun., 238, 387–391.

  • Mootha VK, Wei MC, Buttle KF, Scorrano L, Panoutsakopoulou V, Mannella CA and Korsmeyer SJ . (2001). EMBO J., 20, 661–671.

  • Morishima N, Nakanishi K, Takenouchi H, Shibata T and Yasuhiko Y . (2002). J. Biol. Chem., 277, 34287–34294.

  • Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME and Dixit VM . (1996). Cell, 85, 817–827.

  • Muzio M, Stockwell BR, Stennicke HR, Salvesen GS and Dixit VM . (1998). J. Biol. Chem., 273, 2926–2930.

  • Nahle Z, Polakoff J, Davuluri RV, McCurrach ME, Jacobson MD, Narita M, Zhang MQ, Lazebnik Y, Bar-Sagi D and Lowe SW . (2002). Nat. Cell Biol., 4, 859–864.

  • Nakagawa T and Yuan J . (2000). J. Cell. Biol., 150, 887–894.

  • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA and Yuan J . (2000). Nature, 403, 98–103.

  • Namura S, Zhu J, Fink K, Endres M, Srinivasan A, Tomaselli KJ, Yuan J and Moskowitz MA . (1998). J. Neurosci., 18, 3659–3668.

  • Natori S, Selzner M, Valentino KL, Fritz LC, Srinivasan A, Clavien PA and Gores GJ . (1999). Transplantation, 68, 89–96.

  • Nicholson DW . (2000). Nature, 407, 810–816.

  • Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M and Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yamin T-T, Yu VL and Miller DK . (1995). Nature, 376, 37–43.

  • Nicotera P, Leist M and Ferrando-May E . (1998). Toxicol. Lett., 102–103, 139–142.

  • Nicotera P, Leist M and Ferrando-May E . (1999). Biochem. Soc. Symp., 66, 69–73.

  • Nishimura I, Uetsuki T, Kuwako K, Hara T, Kawakami T, Aimoto S and Yoshikawa K . (2002). Cell Death Differ., 9, 199–208.

  • Oppenheim RW, Flavell RA, Vinsant S, Prevette D, Kuan CY and Rakic P . (2001). J. Neurosci., 21, 4752–4760.

  • Orth K and Dixit VM . (1997). J. Biol. Chem., 272, 8841–8844.

  • Orth K, O'Rourke K, Salvesen GS and Dixit VM . (1996). J. Biol. Chem., 271, 20977–20980.

  • Pandey P, Nakazawa A, Ito Y, Datta R, Kharbanda S and Kufe D . (2000). Oncogene, 19, 3941–3947.

  • Park WS, Lee JH, Shin MS, Park JY, Kim HS, Kim YS, Lee SN, Xiao W, Park CH, Lee SH, Yoo NJ and Lee JY . (2002). Oncogene, 21, 2919–2925.

  • Paroni G, Henderson C, Schneider C and Brancolini C . (2002). J. Biol. Chem., 277, 15147–15161.

  • Pasinelli P, Borchelt DR, Houseweart MK, Cleveland DW and Brown Jr RH . (1998). Proc. Natl. Acad. Sci. USA, 95, 15763–15768.

  • Pistritto G, Jost M, Srinivasula SM, Baffa R, Poyet JL, Kari C, Lazebnik Y, Rodeck U and Alnemri ES . (2002). Cell Death Differ., 9, 995–1006.

  • Pop C, Chen YR, Smith B, Bose K, Bobay B, Tripathy A, Franzen S and Clark AC . (2001). Biochemistry, 40, 14224–14235.

  • Prasad SC, Thraves PJ, Kuettel MR, Srinivasarao GY, Dritschilo A and Soldatenkov VA . (1998). Biochem. Biophys. Res. Commun., 249, 332–338.

  • Quan LT, Caputo A, Bleackley RC, Pickup DJ and Salvesen GS . (1995). J. Biol. Chem., 270, 10377–10379.

  • Ramage P, Cheneval D, Chvei M, Graff P, Hemmig R, Heng R, Kocher HP, Mackenzie A, Memmert K, Revesz L and Wishart W . (1995). J. Biol. Chem., 270, 9378–9383.

  • Randle JC, Harding MW, Ku G, Schonharting M and Kurrle R . (2001). Expert Opin. Invest. Drugs, 10, 1207–1209.

  • Rano TA, Timkey T, Peterson EP, Rotonda J, Nicholson DW, Becker JW, Chapman KT and Thornberry NA . (1997). Chem. Biol., 4, 149–155.

  • Rao L, Perez D and White E . (1996). J. Cell. Biol., 135, 1441–1455.

  • Rao RV, Castro-Obregon S, Frankowski H, Schuler M, Stoka V, del Rio G, Bredesen DE and Ellerby HM . (2002). J. Biol. Chem., 277, 21836–21842.

  • Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM and Bredesen DE . (2001). J. Biol. Chem., 276, 33869–33874.

  • Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS and Pickup DJ . (1992). Cell, 69, 597–604.

  • Renatus M, Stennicke HR, Scott FL, Liddington RC and Salvesen GS . (2001). Proc. Natl. Acad. Sci. USA, 98, 14250–14255.

  • Renatus M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA, Liddington RC and Salvesen GS . (2000). Struct. Fold Des., 8, 789–797.

  • Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS and Bode W . (2001a). Proc. Natl. Acad. Sci. USA, 98, 14790–14795.

  • Riedl SJ, Renatus M, Snipas SJ and Salvesen GS . (2001b). Biochemistry, 40, 13274–13280.

  • Robertson JD, Enoksson M, Suomela M, Zhivotovsky B and Orrenius S . (2002). J. Biol. Chem., 277, 29803–29809.

  • Rodriguez J and Lazebnik Y . (1999). Genes Dev., 13, 3179–3184.

  • Ross CA, Wood JD, Schilling G, Peters MF, Nucifora Jr FC, Cooper JK, Sharp AH, Margolis RL and Borchelt DR . (1999). Philos. Trans. R. Soc. Lond. B. Biol. Sci., 354, 1005–1011.

  • Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA and Becker JW . (1996). Nat. Struct. Biol., 3, 619–625.

  • Roy S, Bayly CI, Gareau Y, Houtzager VM, Kargman S, Keen SL, Rowland K, Seiden IM, Thornberry NA and Nicholson DW . (2001). Proc. Natl. Acad. Sci. USA, 98, 6132–6137.

  • Ruchaud S, Korfali N, Villa P, Kottke TJ, Dingwall C, Kaufmann SH and Earnshaw WC . (2002). EMBO J., 21, 1967–1977.

  • Rudel T . (1999). Herz, 24, 236–241.

  • Rudel T and Bokoch GM . (1997). Science, 276, 1571–1574.

  • Sabourin LA, Tamai K, Seale P, Wagner J and Rudnicki MA . (2000). Mol. Cell. Biol., 20, 684–696.

  • Sakahira H, Enari M, Ohsawa Y, Uchiyama Y and Nagata S . (1999). Curr. Biol., 9, 543–546.

  • Salvesen GS and Dixit VM . (1999). Proc. Natl. Acad. Sci. USA, 96, 10964–10967.

  • Sanchez I, Xu CJ, Juo P, Kakizaka A, Blenis J and Yuan J . (1999). Neuron, 22, 623–633.

  • Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH and Peter ME . (1998). EMBO J., 17, 1675–1687.

  • Scaffidi C, Schmitz I, Krammer PH and Peter ME . (1999). J. Biol. Chem., 274, 1541–1548.

  • Schlaepfer DD, Hauck CR and Sieg DJ . (1999). Prog. Biophys. Mol. Biol., 71, 435–478.

  • Schmeiser K, Hammond EM, Roberts S and Grand RJ . (1998). FEBS Lett., 433, 51–57.

  • Schotte P, Van Criekinge W, Van de Craen M, Van Loo G, Desmedt M, Grooten J, Cornelissen M, De Ridder L, Vandekerckhove J, Fiers W, Vandenabeele P and Beyaert R . (1998). Biochem. Biophys. Res. Commun., 251, 379–387.

  • Selkoe DJ . (2000). Ann. NY Acad. Sci., 924, 17–25.

  • Selkoe DJ . (2001). Physiol. Rev., 81, 741–766.

  • Shao RG, Cao CX and Pommier Y . (1997). J. Biol. Chem., 272, 31321–31325.

  • Sharp PA . (1999). Genes Dev., 13, 139–141.

  • Shi Y . (2002). Mol. Cell, 9, 459–470.

  • Shin MS, Kim HS, Kang CS, Park WS, Kim SY, Lee SN, Lee JH, Park JY, Jang JJ, Kim CW, Kim SH, Lee JY, Yoo NJ and Lee SH . (2002a). Blood, 99, 4094–4099.

  • Shin MS, Kim HS, Lee SH, Lee JW, Song YH, Kim YS, Park WS, Kim SY, Lee SN, Park JY, Lee JH, Xiao W, Jo KH, Wang YP, Lee KY, Park YG, Kim SH, Lee JY and Yoo NJ . (2002b). Oncogene, 21, 4129–4136.

  • Shiozaki EN, Chai J and Shi Y . (2002). Proc. Natl. Acad. Sci. USA, 99, 4197–4202.

  • Siegmund B . (2002). Biochem. Pharmacol., 64, 1–8.

  • Slee EA, Adrain C and Martin SJ . (2001). J. Biol. Chem., 276, 7320–7326.

  • Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR and Martin SJ . (1999). J. Cell. Biol., 144, 281–292.

  • Smith DJ, McGuire MJ, Tocci MJ and Thiele DL . (1997). J. Immunol., 158, 163–170.

  • Smulson ME, Simbulan-Rosenthal CM, Boulares AH, Yakovlev A, Stoica B, Iyer S, Luo R, Haddad B, Wang ZQ, Pang T, Jung M, Dritschilo A and Rosenthal DS . (2000). Adv. Enzyme Regul., 40, 183–215.

  • Soengas MS, Capodieci P, Polsky D, Mora J, Esteller M, Opitz-Araya X, McCombie R, Herman JG, Gerald WL, Lazebnik YA, Cordon-Cardo C and Lowe SW . (2001). Nature, 409, 207–211.

  • Song Q, Lees-Miller SP, Kumar S, Zhang Z, Chan DW, Smith GC, Jackson SP, Alnemri ES, Litwack G, Khanna KK and Lavin MF . (1996). EMBO J., 15, 3238–3246.

  • Sordet O, Rebe C, Plenchette S, Zermati Y, Hermine O, Vainchenker W, Garrido C, Solary E and Dubrez-Daloz L . (2002). Blood, 8, 8.

  • Sprick MR, Rieser E, Stahl H, Grosse-Wilde A, Weigand MA and Walczak H . (2002). EMBO J., 21, 4520–4530.

  • Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J, Krammer PH and Walczak H . (2000). Immunity, 12, 599–609.

  • Springer JE, Azbill RD and Knapp PE . (1999). Nat. Med., 5, 943–946.

  • Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y and Alnemri ES . (2001). Nature, 410, 112–116.

  • Stadelmann C, Deckwerth TL, Srinivasan A, Bancher C, Bruck W, Jellinger K and Lassmann H . (1999). Am. J. Pathol., 155, 1459–1466.

  • Stefanis L, Troy CM, Qi H, Shelanski ML and Greene LA . (1998). J. Neurosci., 18, 9204–9215.

  • Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM and Salvesen GS . (1999). J. Biol. Chem., 274, 8359–8362.

  • Stennicke HR, Renatus M, Meldal M and Salvesen GS . (2000). Biochem. J., 350, 563–568.

  • Stennicke HR and Salvesen GS . (1997). J. Biol. Chem., 272, 25719–25723.

  • Stennicke HR and Salvesen GS . (1999). Cell Death Differ., 6, 1054–1059.

  • Stennicke HR and Salvesen GS . (2000). Biochim. Biophys. Acta, 1477, 299–306.

  • Talanian RV, Brady KD and Cryns VL . (2000). J. Med. Chem., 43, 3351–3371.

  • Tang D and Kidd VJ . (1998). J. Biol. Chem., 273, 28549–28552.

  • Tang G, Yang J, Minemoto Y and Lin A . (2001). Mol. Cell, 8, 1005–1016.

  • Tatton NA . (2000). Exp. Neurol., 166, 29–43.

  • Thompson CB . (1995). Science, 267, 1456–1462.

  • Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Euis Ton KO, Ayala JM, Casano FJ, Chin J, Ding GJF, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA and Tocci MJ . (1992). Nature, 356, 768–774.

  • Thornberry NA, Peterson EP, Zhao JJ, Howard AD, Griffin PR and Chapman KT . (1994). Biochemistry, 33, 3934–3940.

  • Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT and Nicholson DW . (1997). J. Biol. Chem., 272, 17907–17911.

  • Tong X, Liu B, Dong Y and Sun Z . (2000). Int. J. Radiat. Biol., 76, 1387–1395.

  • Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K and Shelanski ML . (2000). J. Neurosci., 20, 1386–1392.

  • Troy CM, Rabacchi SA, Hohl JB, Angelastro JM, Greene LA and Shelanski ML . (2001). J. Neurosci., 21, 5007–5016.

  • U M, Miyashita T, Ohtsuka Y, Okamura-Oho Y, Shikama Y and Yamada M . (2001). Cell Death Differ., 8, 377–386.

  • Ura S, Masuyama N, Graves JD and Gotoh Y . (2001). Proc. Natl. Acad. Sci. USA, 98, 10148–10153.

  • Utz PJ and Anderson P . (2000). Cell Death Differ., 7, 589–602.

  • Van de Craen M, Declercq W, Van den brande I, Fiers W and Vandenabeele P . (1999). Cell Death Differ., 6, 1117–1124.

  • Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W and Vandenabeele P . (1998). Cell Death Differ., 5, 838–846.

  • Vancompernolle K, Van Herreweghe F, Pynaert G, Van de Craen M, De Vos K, Totty N, Sterling A, Fiers W, Vandenabeele P and Grooten J . (1998). FEBS Lett., 438, 150–158.

  • Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P and Wallach D . (1998). Immunity, 9, 267–276.

  • Vogt C . (1842). Sdothum: Jent and Gassman, 130.

  • Walker NP, Talanian RV, Brady KD, Dang LC, Bump NJ, Ferenz CR, Franklin S, Ghayur T, Hackett MC, Hammill LD, Herzog L, Hugunin M, Houy W, Mankovich JA, McGuiness L, Orlewicz E, Paskind M, Pratt CA, Reis P, Summani A, Terranova M, Welch JP, Xiong L, Möller A, Tracey, DE, Kamen R and Wong WW . (1994). Cell, 78, 343–352.

  • Wang J, Chun HJ, Wong W, Spencer DM and Lenardo MJ . (2001). Proc. Natl. Acad. Sci. USA, 98, 13884–13888.

  • Wang J, Zheng L, Lobito A, Chan FK, Dale J, Sneller M, Yao X, Puck JM, Straus SE and Lenardo MJ . (1999). Cell, 98, 47–58.

  • Wang L, Miura M, Bergeron L, Zhu H and Yuan J . (1994). Cell, 78, 739–750.

  • Wang S, Guo M, Ouyang H, Li X, Cordon-Cardo C, Kurimasa A, Chen DJ, Fuks Z, Ling CC and Li GC . (2000). Proc. Natl. Acad. Sci. USA, 97, 1584–1588.

  • Wang S, Miura M, Jung Y, Zhu H, Gagliardini V, Shi L, Greenberg AH and Yuan J . (1996). J. Biol. Chem., 271, 20580–20587.

  • Wang S, Miura M, Jung YK, Zhu H, Li E and Yuan J . (1998). Cell, 92, 501–509.

  • Watabe M, Kakeya H and Osada H . (1999). Oncogene, 18, 5211–5220.

  • Waterhouse N, Kumar S, Song Q, Strike P, Sparrow L, Dreyfuss G, Alnemri ES, Litwack G, Lavin M and Watters D . (1996). J. Biol. Chem., 271, 29335–29341.

  • Waterhouse NJ, Goldstein JC, von Ahsen O, Schuler M, Newmeyer DD and Green DR . (2001). J. Cell. Biol., 153, 319–328.

  • Watt W, Koeplinger KA, Mildner AM, Heinrikson RL, Tomasselli AG and Watenpaugh KD . (1999). Struct. Fold Des., 7, 1135–1143.

  • Wei Y, Fox T, Chambers SP, Sintchak J, Coll JT, Golec JM, Swenson L, Wilson KP and Charifson PS . (2000). Chem. Biol., 7, 423–432.

  • Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW and Hayden MR . (2002). J. Neurosci., 22, 7862–7872.

  • Wen LP, Fahrni JA, Troie S, Guan JL, Orth K and Rosen GD . (1997). J. Biol. Chem., 272, 26056–26061.

  • Widmann C, Gerwins P, Johnson NL, Jarpe MB and Johnson GL . (1998a). Mol. Cell. Biol., 18, 2416–2429.

  • Widmann C, Gibson S and Johnson GL . (1998b). J. Biol. Chem., 273, 7141–7147.

  • Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA and Livingston DJ . (1994). Nature, 370, 270–275.

  • Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW and Mak TW . (1998). Genes Dev., 12, 806–819.

  • Wyllie AH, Kerr JF and Currie AR . (1980). Int. Rev. Cytol., 68, 251–306.

  • Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG and Wu H . (2001). Nature, 410, 494–497.

  • Xue D and Horvitz HR . (1995). Nature, 377, 248–251.

  • Yamin TT, Ayala JM and Miller DK . (1996). J. Biol. Chem., 271, 13273–13282.

  • Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP and Wang X . (1997). Science, 275, 1129–1132.

  • Yang X . (2002). Cancer Biol. Ther., 1, 407–408.

  • Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV and Mak TW . (2000). Immunity, 12, 633–642.

  • Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, El-Deiry WS, Lowe SW, Goeddel DV and Mak TW . (1998). Science, 279, 1954–1958.

  • Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA and Koismeyer SJ . (1999). Nature, 400, 886–891.

  • Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, Penninger JM and Mak TW . (1998). Cell, 94, 739–750.

  • Yuan J and Horvitz HR . (1992). Development, 116, 309–320.

  • Yuan J, Shaham S, Ledoux S, Ellis HM and Horvitz HR . (1993). Cell, 75, 641–652.

  • Zermati Y, Garrido C, Amsellem S, Fishelson S, Bouscary D, Valensi F, Varet B, Solary E and Hermine O . (2001). J. Exp. Med., 193, 247–254.

  • Zhang J, Cado D, Chen A, Kabra NH and Winoto A . (1998). Nature, 392, 296–300.

  • Zheng TS, Hunot S, Kuida K, Momoi T, Srinivasan A, Nicholson DW, Lazebnik Y and Flavell RA . (2000). Nat. Med., 6, 1241–1247.

  • Zheng TS, Schlosser SF, Dao T, Hingorani R, Crispe IN, Boyer JL and Flavell RA . (1998). Proc. Natl. Acad. Sci. USA, 95, 13618–13623.

  • Zhou BB, Li H, Yuan J and Kirschner MW . (1998). Proc. Natl. Acad. Sci. USA, 95, 6785–6790.

  • Zou H, Henzel WJ, Liu X, Lutschg A and Wang X . (1997). Cell, 90, 405–413.

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, 02115, MA, USA

    Alexei Degterev, Michael Boyce & Junying Yuan

Authors
  1. Alexei Degterev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael Boyce
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Junying Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Junying Yuan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Degterev, A., Boyce, M. & Yuan, J. A decade of caspases. Oncogene 22, 8543–8567 (2003). https://doi.org/10.1038/sj.onc.1207107

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1207107

Keywords

This article is cited by

Search

Advanced search

Quick links