Figure 6 | Oncogene

Figure 6

From: The MRP family of drug efflux pumps

Figure 6

Schematic depicting the proposed function of MRP3 during cholestasis. Under normal conditions, bile acids such as glycocholic acid and conjugates such as bilirubin glucuronide are extruded across the (apical) canalicular membrane of hepatocytes by the bile salt export pump (BSEP, SPGP) and MRP2, respectively. MRP3, which is located in basolateral membranes of hepatocytes (and cholangiocytes), is markedly induced in cholestatic conditions. The ability of MRP3 to mediate the transport of both monoanionic bile acids and conjugates suggests that it may function as a basolateral back-up system to extrude these compounds into sinusoidal blood when the canalicular route is blocked

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