Abstract
Bcl-2 is an antiapoptotic protein expressed in a wide variety of cell types. We have found that overexpression of bcl-2 in PC12 neural crest tumor cells leads to increased expression of neural differentiation-associated genes and decreased expression of proliferation-related genes. Culture growth rate decreases as well. Overexpression of bcl-2 also leads to increased expression of TrkA and increased phosphorylation of signal transductants in, albeit not specific for, the TrkA–MEK–ERK pathway. Blocking of NGF-mediated signaling through TrkA prevents Bcl-2-associated expression changes in differentiation-associated genes, raising the possibility that Bcl-2 mediates induction of neural differentiation through TrkA/NGF signaling.
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Liang, Y., Mirnics, Z., Yan, C. et al. Bcl-2 mediates induction of neural differentiation. Oncogene 22, 5515–5518 (2003). https://doi.org/10.1038/sj.onc.1206844
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DOI: https://doi.org/10.1038/sj.onc.1206844
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