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Therapeutic approaches to AIDS-related malignancies

Oncogene volume 22, pages 6646–6659 (2003)Cite this article

Abstract

The introduction of highly active antiretroviral therapy (HAART) has changed dramatically the landscape of HIV disease. Deaths from AIDS-related diseases have been reduced by 75% since protease inhibitor therapy and combination antiretroviral therapy came into use in late 1995. While KS is declining, the situation for non-Hodgkin's lymphoma is more complex with a reduced incidence of primary central nervous system lymphoma, but a relatively stability in the number of patients de-veloping systemic NHL. AIDS related NHL appears not to be markedly decreased by the introduction of HAART and it is the greatest therapeutic challenge in the area of AIDS oncology. The emphasis has now shifted to cure while maintaining vigilance regarding the unique vulnerability of HIV-infected hosts. Furthermore, also for the prolongation of the survival expectancy of these patients, other non AIDS-defining tumors, such as Hodgkin's disease, anal and head and neck, lung and testicular cancer, and melanoma have been recently reported with increased frequency in patients with HIV infection.

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Article 17 August 2023

Linda-Gail Bekker, Chris Beyrer, … Jeffrey V. Lazarus

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  1. Massimiliano Berretta, Roberta Cinelli and Ferdinando Martellotta: These three authors contributed equally to this work

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  1. Division of Medical Oncology A, Centro di Riferimento Oncologico, National Cancer Institute, Via Pedemontana Occ.Le 12, Aviano, (PN) 33081, Italy

    Massimiliano Berretta, Roberta Cinelli, Ferdinando Martellotta, Michele Spina, Emanuela Vaccher & Umberto Tirelli

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Berretta, M., Cinelli, R., Martellotta, F. et al. Therapeutic approaches to AIDS-related malignancies. Oncogene 22, 6646–6659 (2003). https://doi.org/10.1038/sj.onc.1206771

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