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Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades

Oncogene volume 22, pages 5141–5149 (2003)Cite this article

Abstract

The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease, HTLV-I-associated myelopathy/tropical spastic paraparesis. HTLV-I encodes an oncogenic protein, Tax, which affects a variety of cellular functions prompting it to be referred to as a jack-of-all trades. The ability of Tax to both transcriptionally regulate cellular gene expression and to functionally inactivate proteins involved in cell-cycle progression and DNA repair provide the basis for Tax-mediated transformation and leukemogenesis. This review will concentrate on the effects of Tax on the dysregulation of the G1/S and G2/M checkpoints as well as the suppression of DNA damage repair leading to cellular transformation.

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Acknowledgements

We acknowledge the members of the Marriott laboratory, especially Dr Diane Wycuff, for their helpful suggestions and editorial comments. The work described in this review was supported in part by the United States Public Service Grant CA-77371 from National Cancer Institute, National Institutes of Health, awarded to SJ Marriott. JC Watt and ML Gatza were supported in part by National Institutes of Health Training Grant CA-09197.

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  1. Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, TX, USA

    Michael L Gatza & Susan J Marriott

  2. Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, TX, USA

    Julie C Watt & Susan J Marriott

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Gatza, M., Watt, J. & Marriott, S. Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades. Oncogene 22, 5141–5149 (2003). https://doi.org/10.1038/sj.onc.1206549

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