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  • Oncogenomics
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Data mining the p53 pathway in the Fugu genome: evidence for strong conservation of the apoptotic pathway

Oncogene volume 22, pages 5082–5090 (2003)Cite this article

Abstract

The p53 tumour suppressor gene belongs to a small family of related proteins that includes two other members, p63 and p73. Phylogenetic and functional studies suggest that p63 and p73 are ancient genes that have essential roles in normal development, whereas p53 seems to have evolved more recently to prevent cell transformation. In mammalian cells, a plethora of proteins have been found to specifically regulate p53 activity. The genome of the fish Fugu rubripes has been recently published. It is the second vertebrate genome for which the entire sequence is now available. Phylogenetic studies are essential in order to analyse and define signalling pathways important for cell cycle regulation. The presence or absence of a critical member in any pathway can shed light about the evolution of these pathways. The Fugu genome databank has been analysed for several members of the p53 network, including p53, p63 and p73. A good conservation of the network that regulates p53 stability and apoptosis has been found. We also discovered that some cofactors that cooperate with p53 for apoptosis are also well conserved and belong to multigene families not detected in the human genome.

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Acknowledgements

MLB is supported by a fellowship from the Société Française du Cancer, Association pour la Recherche sur le Cancer and Fondation pour la recherche médicale, KB by a fellowship from the Ligue Nationale contre le Cancer (Comité National). Work in the laboratory of TS is supported by the Association pour la Recherche sur le Cancer, Ligue Nationale contre le Cancer (comité de Paris) and Ministère pour l'enseignement supérieur et la Recherche.

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Author notes

  1. Morgane Le Bras

    Present address: Université de Versailles Saint Quentin, CNRS FRE 2445-LGBC, 45 avenue des Etats-Unis, 78035, Versailles, France

  2. Karim Bensaad

    Present address: Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61. 1BD, Scotland

Authors and Affiliations

  1. Laboratoire de Génotoxicologie des Tumeurs, Institut Curie, 26 rue d'Ulm, Paris, 75005, France

    Morgane Le Bras, Karim Bensaad & Thierry Soussi

  2. Université P.M. Curie, 4 Place Jussieu, Paris, 75005, France

    Thierry Soussi

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  1. Morgane Le Bras
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Correspondence to Thierry Soussi.

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Le Bras, M., Bensaad, K. & Soussi, T. Data mining the p53 pathway in the Fugu genome: evidence for strong conservation of the apoptotic pathway. Oncogene 22, 5082–5090 (2003). https://doi.org/10.1038/sj.onc.1206424

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