Table 2 The 89 genes for which expression levels differed between HBV-HCCs from patients with LC and those without LC

From: Differential gene expression in distinct virologic types of hepatocellular carcinoma: association with liver cirrhosis

Function Fisher ratio Accession no. Gene name Abbreviation Location
72 genes upregulated in HBV-HCC from patients without LC      
 Cell adhesion and motility/extracellular matrix 4.731 L19711 Dystroglycan 1 DAG1 3p21
  3.589 L36531 Integrin, alpha 8 ITGA8 10p12.32
  3.104 M21812 (Clone PWHLC2-24) myosin light chain 2 HUMMLC2B  
  3.074 L20815 Corneodesmosin CDSN 6p21.3
  2.441 L34060 Cadherin 8, type 2 CDH8 16q22.1
  2.294 X73113 Myosin binding protein C, fast type MYBPC2 19q13.33
 Cell proliferation/apoptosis 3.937 D86962 Growth factor receptor-bound protein 10 GRB10 7p12–p11.2
  2.620 X61615 Leukemia inhibitory factor receptor LIFR 5p13–p12
  2.221 HG3543-HT3739 Insulin-like growth factor 2 IGF2 11p15.5
 DNA bininding/DNA modification 3.682 X78627 Translin TSN 2q21.1
  3.210 U50315 Human enhancer of zeste homolog 1 EZH1 17q21.1–q21.3
  3.167 M11353 H3 histone, family 3A H3F3A 1q41
  2.490 HG3454-HT3647 Zinc finger protein 121 (clone ZHC32) ZNF121 19p
  2.473 X05855 H3 histone, family 3A H3F3A 1q41
  2.282 HG4332-HT4602 Zinc finger protein 77 (pT1) ZNF77 19p
  2.211 L13848 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 DDX9 1q25
 Immune system 5.294 M33680 CD81 antigen CD81 11p15.5
  5.022 M65134 Complement component C5 C5 9q32–q34
  3.910 M28879 Granzyme B GZMB 14q11.2
 Metabolism 6.888 M60527 Deoxycytidine kinase DCK 4q13.3–q21.1
  3.241 M10612 Apolipoprotein C-II APOC2 19q13.2
  2.993 X01388 Apolipoprotein C-III APOC3 11q23.1–23.2
  2.844 M20902 Apolipoprotein C-I APOC1 19q13.2
  2.808 U29463 Cytochrome b-561 CYB561 17q11–qter
  2.708 L00635 Farnesyltransferase, CAAX box, beta FNTB 14q23–q24
  2.597 D29805 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1 B4GALT1 9p13
  2.468 M15465 Pyruvate kinase type L PKLR 1q21
  2.369 M58525 Catechol-O-methyltransferase COMT 22q11.21
 Molecule transport 10.876 M55531 Solute carrier family 2 (GLUT5) SLC2A5 1p36.2
  4.273 AB001325 Aquaporin 3 AQP3 9p13
  3.018 S78203 H+/peptide cotransporter SLC15A2 3q13.33
  2.690 Z18956 Solute carrier family 6, member 6 SLC6A6 3p25–p24
  2.457 U02632 Calcium-activated potassium channel mRNA   
  2.325 L25085 Protein translocation complex beta SEC61B 9q22.32–q31.3
 Oncogene/tumor suppressor genes 3.798 U68485 Box-dependent MYC-interacting protein-1 BIN1 2q14
  3.130 L78132 Galectin 8 (PCTA1) LGALS8 1q42–q43
 Protein modification 8.429 M73720 Carboxypeptidase A CPA3 3q21–q25
  2.432 U84569 Chromosome 21 open reading frame 2 C21orf2 21q22.3
 Signal transduction 3.558 X69920 Calcitonin receptor CALCR 7q21.3
  3.485 A28102 GABAa receptor alpha-3 GABRA3 Xq28
  3.224 M21985 Nuclear receptor subfamily 2, group C, member 1 NR2C1 12q21.32–q21.33
  3.148 M22490 Bone morphogenetic protein 4 BMP4 14q22–q23
  3.085 M62994 Filarmin B, beta FLNB 3p14.3
  2.852 U31384 Guanine nucleotide binding protein 11 GNG11 7q31–q32
  2.837 M84371 CD19 antigen CD19 16p11.2
  2.682 D87467 Guanine nucleotide exchange factor for Rap1 GFR 7p21.3
  2.625 HG4114-HT4384 Olfactory receptor, family 1, subfamily G, member 1 ORIG1 17p13.3
  2.410 L77886 Protein tyrosine phosphatase, receptor type, K PTPRK 6q22.2–q23.1
  2.318 U48405 G protein-coupled receptor 68 GPR68 14q31
  2.224 U34587 Corticotropin releasing hormone receptor 2 CRHR2 7p15.3
 Transcription 5.606 U85193 Nuclear factor I/B NFIB 9p24.1
  3.165 L19314 Hairy homolog (Drosophila) HRY 3q28–q29
  3.124 U67369 Growth factor independent 1 GFI1 1p22
  2.572 X07024 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor TAF1 Xq13.1
  2.542 U77975 One cut domain, family member 1 ONECUT1 15q21.1–q21.2
  2.345 D79986 Bcl-2-associated transcription factor BTF 6q22.2–q23
  2.302 U18543 Tripartite motif-containing 32 TRIM32 9q33.1
 Others/unknown 6.718 L43579 Homo sapiens (clone 110298) mRNA EST Xp28
  5.820 U57341 Neurofilament triplet L protein   17q21.3
  4.633 D87742 KIAA0268 gene KIAA0268 unknown
  3.451 D87437 Chromosome 1 open reading frame 16 C1orf16 1q35
  3.368 D14662 Antioxidant protein 2 AOP2 1q23.3
  3.331 U79296 Centaurin-alpha2 protein   
  3.286 D31815 Regucalcin (senescence marker protein-30) RGN Xp11.3–q11.2
  3.145 X97249 FSH primary response FSHPRH1 Xq22
  2.899 AF008937 Syntaxin-16C   
  2.847 D13634 KIAA0009 gene product KIAA0009 8q12.1
  2.842 U45974 Phosphatidylinositol (4,5) bisphosphate 5-phosphatase homolog PPI5PIV 9q34.3
  2.816 Z24724 Hypothetical protein FLJ20986 FLJ20986 3q29
  2.626 D83243 Nuclear protein, ataxia-telangiectasia locus NPAT 11q22–q23
  2.581 U79291 Hypothetical protein MGC14433 MGC14433 12q24.11
19 genes upregulated in HBV-HCC from patients with LC 2.239 Z47055 Farnesyl pyrophosphate synthetase like-4   15q15
 Cell proliferation/apoptosis 2.256 M35878 Insulin-like growth factor binding protein 3 IGFBP3 7p13–p12
 Metabolism 4.934 X60673 Adenylate kinase 3 AK3 9p24–p13
  3.380 D29643 KIAA0115 gene DDOST 1p36.1
  2.815 D63998 Mannosidase, alpha, class 2A, member 1 MAN2A1 5q21–q22
  2.790 Y00486 Adenine phosphoribosyltransferase APRT 16q24
  3.657 U79254 Asparaginyl-tRNA synthetase NARS 18q21.2–q21.3
  2.356 X55079 Lysosomal alpha-glucosidase GAA 17q25.2–q25.3
 Molecule transport 2.716 U26648 Syntaxin 5A STX5A 11q13.1
  2.640 X69838 H.sapiens mRNA for G9a NG22 6p21.3
 mRNA processing 5.070 D86988 Regulator of nonsense transcripts 1 RENT1 19p13.2–p13.11
  2.579 L14076 Splicing factor, arginine/serine-rich 4 SFRS4 1p35.2
 Oncogene/tumor suppressor gene 2.795 S85655 Prohibitin PHB 17q21
 Protein modification 2.764 M34539 FK506 binding protein 1A (12 kD) FKBP1A 20p13
 Structural protein 3.070 HG3636-HT3846 Myosin, heavy polypeptide 9, nonmuscle   
 Transcription 4.901 J03827 Nuclease sensitive element binding protein 1 NSEP1 1p34
 Unknown 3.105 D31887 KIAA0062 protein KIAA0062 8p21.2
  2.843 D86982 KIAA0229 protein KIAA0229 6p21.2
  1. Accession number of each gene was obtained from PubMed or the Institute for Genome Research database
  2. Gene symbols used are based on the data LocusLINK