Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Dynamics and diversions in base excision DNA repair of oxidized abasic lesions

Oncogene volume 21, pages 8926–8934 (2002)Cite this article

Research on the repair of DNA lesions formed by reactions with cellular by-products has focused particularly on oxidative damage. Evidence exists for the formation of oxidative DNA damage in cells during normal growth, but virtually all of this work has centered on the analysis of various base lesions (Dizdaroglu et al., 2002). Our understanding of the repair of such lesions has been enhanced by studies of repair in response to DNA damage induced in cells exposed to chemical oxidants, certain antitumor drugs, or ionizing radiation, which carry out the same or similar reactions with DNA (Dedon and Goldberg, 1992; von Sonntag, 1987).

Since the 1950's it has been known that most DNA damage caused by ionizing radiation results from the generation of free radicals in the medium along an energy deposition track (von Sonntag, 1987). These short-lived radicals react with nearby molecules, such as DNA. Most of the atoms comprising DNA are subject to attack (von Sonntag, 1987). Although dL was the first radiation lesion specified chemically, the subsequent research effort focused largely on identifying DNA base modifications rather than deoxyribose damage. Ironically, the most frequently measured indicator of radiation damage, DNA strand breakage, results from the formation of OAS (von Sonntag, 1987).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  • Bennett RA, Swerdlow PS, Povirk LF . 1993 Biochemistry 32: 3188–3195

  • Bennett RAO . 1999 Mol. Cell. Biol. 19: 1800–1809

  • Bernelot-Moens C, Demple B . 1989 Nucleic. Acids Res. 17: 587–600

  • Betti M, Petrucco S, Bolchi A, Dieci G, Ottonello S . 2001 J. Biol. Chem. 276: 18038–18045

  • Blaisdell JO, Wallace SS . 2001 Proc. Natl. Acad. Sci. USA 98: 7426–7430

  • Cappelli E, Hazra T, Hill JW, Slupphaug G, Bogliolo M, Frosina G . 2001 Carcinogenesis 22: 387–393

  • Chan E, Weiss B . 1987 Proc. Natl. Acad. Sci. USA 84: 3189–3193

  • Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC . 2002 EMBO J. 21: 2827–2832

  • Chatgilialoglu C, O'Neill P . 2001 Exp. Gerontol. 36: 1459–1471

  • Chaudhry MA, Dedon PD, Wilson DM, Demple B, Weinfeld M . 1999 Biochem. Pharmacol. 57: 531–538

  • Chen DS, Herman T, Demple B . 1991 Nucleic Acids Res. 19: 5907–5914

  • Cunningham RP, Saporito SM, Spitzer SG, Weiss B . 1986 J. Bacteriol. 168: 1120–1127

  • David-Cordonnier MH, Laval J, O'Neill P . 2001 Biochemistry 40: 5738–5746

  • Dedon PC, Goldberg IH . 1992 Chem. Res. Toxicol. 5: 311–332

  • DeMott MS, Beyret E, Wong D, Bales BC, Hwang JT, Greenberg MM, Demple B . 2002 J. Biol. Chem. 277: 7637–7640

  • DeMott MS, Shen B, Park MS, Bambara RA, Zigman S . 1996 J. Biol. Chem. 271: 30068–30076

  • DeMott MS, Zigman S, Bambara RA . 1998 J. Biol. Chem. 273: 27492–27498

  • Demple B, Halbrook J, Linn S . 1983 J. Bacteriol. 153: 1079–1082

  • Demple B, Harrison L . 1994 Annu. Rev. Biochem. 63: 915–948

  • Demple B, Herman T, Chen DS . 1991 Proc. Natl. Acad. Sci. USA 88: 11450–11454

  • Demple B, Johnson A, Fung D . 1986 Proc. Natl. Acad. Sci. USA 83: 7731–7735

  • Dianov G, Lindahl T . 1994 Curr. Biol. 4: 1069–1076

  • Dianov GL, Prasad R, Wilson SH, Bohr VA . 1999 J. Biol. Chem. 274: 13741–13743

  • Dizdaroglu M, Jaruga P, Birincioglu M, Rodriguez H . 2002 Free Radic. Biol. Med. 32: 1102–1115

  • Feng JA, Crasto CJ, Matsumoto Y . 1998 Biochemistry 37: 9605–9611

  • Fortini P, Pascucci B, Parlanti E, Sobol RW, Wilson SH, Dogliotti E . 1998 Biochemistry 37: 3575–3580

  • Frosina G, Fortini P, Rossi O, Carrozzino F, Raspaglio G, Cox LS, Lane DP, Abondandolo A, Dogliotti E . 1996 J. Biol. Chem. 271: 9573–9578

  • Fung H, Kow YW, Van Houten B, Taatjes DJ, Hatahet Z, Janssen YM, Vacek P, Faux SP, Mossman BT . 1998 Cancer Res. 58: 189–194

  • Giloni L, Takeshita M, Johnson F, Iden C, Grollman AP . 1981 J. Biol. Chem. 256: 8608–8615

  • Goodhead DT . 1994 Int. J. Radiat. Biol. 65: 7–17

  • Grosch S, Fritz G, Kaina B . 1998 Cancer Res. 58: 4410–4416

  • Grosch S, Kaina B . 1999 Biochem. Biophys. Res. Commun. 261: 859–863

  • Hadi MZ, Ginalski K, Nguyen LH, Wilson 3rd DM . 2002 J. Mol. Biol. 316: 853–866

  • Hadi MZ, Wilson DM . 2000 Environ. Mol. Mutagen. 36: 312–324

  • Häring M, Rudiger H, Demple B, Boiteux S, Epe B . 1994 Nucleic Acids Res. 22: 2010–2015

  • Harrison L, Hatahet Z, Purmal AA, Wallace SS . 1998 Nucleic Acids Res. 26: 932–941

  • Hashimoto M, Greenberg MM, Kow YW, Hwang JT, Cunningham RP . 2001 Journal of the American Chemical Society 123: 3161–3162

  • Hengge-Aronis R . 1999 Curr. Opin. Microbiol. 2: 148–152

  • Henner WD, Rodriguez LO, Hecht SM, Haseltine WA . 1983 J. Biol. Chem. 258: 711–713

  • Hwang JT, Tallman KA, Greenberg MM . 1999 Nucleic Acids Res. 27: 3805–3810

  • Ide H, Tedzuka K, Shimzu H, Kimura Y, Purmal AA, Wallace SS, Kow YW . 1994 Biochemistry 33: 7842–7847

  • Izumi T, Hazra TK, Boldogh I, Tomkinson AE, Park MS, Ikeda S, Mitra S . 2000 Carcinogenesis 21: 1329–1334

  • Jilani A, Ramotar D . 2002 Biochemistry 41: 7688–7694

  • Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, Lasko DD . 1999a J. Biol. Chem. 274: 24176–24186

  • Jilani A, Slack C, Matheos D, Zannis-Hadjopoulos M, Lasko DD . 1999b J. Cell Biochem. 73: 188–203

  • Johnson AW, Demple B . 1988a J. Biol. Chem. 263: 18017–18022

  • Johnson AW, Demple B . 1988b J. Biol. Chem. 263: 18009–18016

  • Johnson RE, Kovvali GK, Prakash L, Prakash S . 1998a Curr. Genet. 34: 21–29

  • Johnson RE, Torres-Ramos CA, Izumi T, Mitra S, Prakash S, Prakash L . 1998b Genes Dev. 12: 3137–3143

  • Jourdan M, Garcia J, Defrancq E, Kotera M, Lhomme J . 1999 Biochemistry 38: 3985–3995

  • Kanno S, Iwai S, Takao M, Yasui A . 1999 Nucleic Acids Res. 27: 3096–3103

  • Karmakar P, Balajee AS, Natarajan AT . 2001 Mutagenesis 16: 225–232

  • Klungland A, Lindahl T . 1997 EMBO J. 16: 3341–3348

  • Kotera M, Roupioz Y, Defrancq E, Bourdat AG, Garcia J, Coulombeau C, Lhomme J . 2000 Chemistry 6: 4163–4169

  • Lenox HJ, McCoy CP, Sheppard TL . 2001 Org. Lett. 3: 2415–2418

  • Levin JD, Demple B . 1996 Nucleic Acids Res. 24: 885–889

  • Marshall LE, Graham DR, Reich KA, Sigman DS . 1981 Biochemistry 20: 244–250

  • Martindale JL, Holbrook NJ . 2002 J. Cell. Physiol. 192: 1–15

  • Matsumoto Y, Kim K . 1995 Science 269: 699–702

  • Matsumoto Y, Kim K, Bogenhagen DF . 1994 Mol. Cell. Biol. 14: 6187–6197

  • Matsumoto Y, Kim K, Hurwitz J, Gary R, Levin DS, Tomkinson AE, Park MS . 1999 J. Biol. Chem. 274: 33703–33708

  • Meijler MM, Zelenko O, Sigman DS . 1997 Journal of the American Chemical Society 119: 1135–1136

  • Minko IG, Zou Y, Lloyd RS . 2002 Proc. Natl. Acad. Sci. USA 99: 1905–1909

  • Mol CD, Hosfield DJ, Tainer JA . 2000 Mutat. Res. 460: 211–229

  • Murante RS, Rust L, Bambara RA . 1995 J. Biol. Chem. 270: 30377–30383

  • Nakamura J, La DK, Swenberg JA . 2000 J. Biol. Chem. 275: 5323–5328

  • Nakamura J, Swenberg JA . 1999 Cancer Res. 59: 2522–2526

  • Olivares M, Thomas MC, Alonso C, Lopez MC . 1999 J. Biol. Chem. 274: 23883–23886

  • Ono Y, Furuta T, Ohmoto T, Akiyama K, Seki S . 1994 Mutation Research 315: 55–63

  • Perrin DM, Mazumder A, Sigman DS . 1996 Progress in Nucleic Acid Research & Molecular Biology 52: 123–151

  • Piersen CE, Prasad R, Wilson SH, Lloyd RS . 1996 J. Biol. Chem. 271: 17811–17815

  • Pomposiello PJ, Bennik MH, Demple B . 2001 J. Bacteriol. 183: 3890–3902

  • Pomposiello PJ, Demple B . 2002 Adv. Microb. Physiol. 46: 319–341

  • Pope LM, Reich KA, Graham DR, Sigman DS . 1982 Journal of Biological Chemistry 257: 12121–12128

  • Popoff SC, Spira AI, Johnson AW, Demple B . 1990 Proc. Natl. Acad. Sci. USA 87: 4193–4197

  • Povirk LF . 1996 Mutation Research 355: 71–89

  • Prasad R, Dianov GL, Bohr VA, Wilson SH . 2000 J. Biol. Chem. 275: 4460–4466

  • Raleigh JA . 1989 Free Radic. Res. Commun. 6: 141–143

  • Ramana CV, Boldogh I, Izumi T, Mitra S . 1998 Proc. Natl. Acad. Sci. USA 95: 5061–5066

  • Ramotar D, Kim C, Lillis R, Demple B . 1993 J. Biol. Chem. 268: 20533–20539

  • Ramotar D, Popoff SC, Gralla EB, Demple B . 1991 Mol. Cell Biol. 11: 4537–4544

  • Richardson CC, Lehman IR, Kornberg A . 1964 J. Biol. Chem. 239: 251–258

  • Robson CN, Hickson ID . 1991 Nucleic Acids Res. 19: 5519–5523

  • Sak BD, Eisenstark A, Touati D . 1989 Proc. Natl. Acad. Sci. USA 86: 3271–3275

  • Sander M, Huang SM . 1995 Biochemistry 34: 1267–1274

  • Sander M, Ramotar D . 1997 Biochemistry 36: 6100–6106

  • Seki S, Akiyama K, Watanabe S, Hatsushika M, Ikeda S, Tsutsui K . 1991a J. Biol. Chem. 266: 20797–20802

  • Seki S, Ikeda S, Watanabe S, Hatsushika M, Tsutsui K, Akiyama K, Zhang B . 1991b Biochim. Biophys. Acta 1079: 57–64

  • Siwek B, Bricteux-Gregoire S, Bailly V, Verly WG . 1988 Nucleic Acids Res. 16: 5031–5038

  • Sobol RW, Horton JK, Kuhn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH . 1996 Nature 379: 183–186

  • Soltis DA, Uhlenbeck OC . 1982 J. Biol. Chem. 257: 11332–11339

  • Sommers CH, Miller EJ, Dujon B, Prakash S, Prakash L . 1995 J. Biol. Chem. 270: 4193–4196

  • Srivastava DK, Berg BJ, Prasad R, Molina JT, Beard WA, Tomkinson AE, Wilson SH . 1998 J. Biol. Chem. 273: 21203–21209

  • Strauss PR, Beard WA, Patterson TA, Wilson SH . 1997 J. Biol. Chem. 272: 1302–1307

  • Sutherland BM, Bennett PV, Sidorkina O, Laval J . 2000a Biochemistry 39: 8026–8031

  • Sutherland BM, Bennett PV, Sidorkina O, Laval J . 2000b Proc. Natl. Acad. Sci. USA 97: 103–108

  • Tom S, Henricksen LA, Bambara RA . 2000 J. Biol. Chem. 275: 10498–10505

  • Tsuchimoto D, Sakai Y, Sakumi K, Nishioka K, Sasaki M, Fujiwara T, Nakabeppu Y . 2001 Nucleic Acids Res. 29: 2349–2360

  • Unk I, Haracska L, Prakash S, Prakash L . 2001 Mol. Cell Biol. 21: 1656–1661

  • Von Sonntag C . 1987 The Chemical Basis of Radiation Biology London: Taylor and Francis

    Google Scholar 

  • Walker LJ, Craig RB, Harris AL, Hickson ID . 1994 Nucleic Acids Res. 22: 4884–4889

  • Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW . 2001 Cell 104: 107–117

  • Wilson DM, Bennett RA, Marquis JC, Ansari P, Demple B . 1995 Nucleic Acids Res. 23: 5027–5033

  • Winters TA, Henner WD, Russell PS, McCullough A, Jorgensen TJ . 1994 Nucleic Acids Res. 22: 1866–1873

  • Xanthoudakis S, Miao G, Wang F, Pan YC, Curran T . 1992 EMBO J. 11: 3323–3335

  • Xanthoudakis S, Miao GG, Curran T . 1994 Proc. Natl. Acad. Sci. USA 91: 23–27

  • Xu Y, DeMott MS, Greenberg MM, Demple B . 2002 DNA Repair. in press

  • Xu YJ, Kim EY, Demple B . 1998 J. Biol. Chem. 273: 28837–28844

  • Zelenko O, Gallagher J, Xu Y, Sigman DS . 1998 Inorganic Chemistry 37: 2198–2204

Download references

Author information

Authors and Affiliations

  1. Department of Cancer Cell Biology, Harvard School of Public Health, Boston, 02115, MA, USA

    Bruce Demple & Michael S DeMott

Authors
  1. Bruce Demple
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael S DeMott
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bruce Demple.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Demple, B., DeMott, M. Dynamics and diversions in base excision DNA repair of oxidized abasic lesions. Oncogene 21, 8926–8934 (2002). https://doi.org/10.1038/sj.onc.1206178

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1206178

Keywords

This article is cited by

Search

Advanced search

Quick links