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Hematopoietic cytokines, transcription factors and lineage commitment

Abstract

The past two decades have witnessed significant advances in our understanding of the cellular physiology and molecular regulation of hematopoiesis. At the heart of stem cell self-renewal and lineage commitment decisions lies the relative expression levels of lineage-specific transcription factors. The expression of these transcription factors in early stem cells may be promiscuous and fluctuate, but ultimately comes under the influence of extracellular regulatory signals in the form of hematopoietic cytokines. In this review, we first summarize our current understanding of the phenotypic characterization of hematopoietic stem cells. Next, we describe key known transcription factors which govern stem cell self-renewal and lineage commitment decisions. Finally, we review data concerning the role of specific cytokines in influencing these decisions. From this review, a picture emerges in which stem cell fate decisions are governed by the integrated effects of intrinsic transcription factors and external signaling pathways initiated by regulatory cytokines.

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References

  • Akashi K, Reya T, Dalma-Weiszhausz D, Weissman IL . 2000a Curr. Opin. Immunol. 12: 144–150

  • Akashi K, Traver D, Miyamoto T, Weissman IL . 2000b Nature 404: 193–197

  • Allman D, Li J, Hardy RR . 1999 J. Exp. Med. 189: 735–740

  • Anderson KL, Smith KA, Conners K, McKercher SR, Maki RA, Torbett BE . 1998a Blood 91: 3702–3710

  • Anderson KL, Smith KA, Pio F, Torbett BE, Maki RA . 1998b Blood 92: 1576–1585

  • Antonchuk J, Sauvageau G, Humphries RK . 2001 Exp. Hematol. 29: 1125–1134

  • Bain G, Engel I, Robanus Maandag EC, te Riele HP, Voland JR, Sharp LL, Chun J, Huey B, Pinkel D, Murre C . 1997 Mol. Cell. Biol. 17: 4782–4791

  • Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M et al . 1994 Cell 79: 885–892

  • Barnache S, Wendling F, Lacombe C, Denis N, Titeux M, Vainchenker W, Moreau-Gachelin F . 1998 Oncogene 16: 2989–2995

  • Batard P, Monier MN, Fortunel N, Ducos K, Sansilvestri-Morel P, Phan T, Hatzfeld A, Hatzfeld JA . 2000 J. Cell. Sci. 113: 383–390

  • Benbernou N, Muegge K, Durum SK . 2000 J. Biol. Chem. 275: 7060–7065

  • Bhardwaj G, Murdoch B, Wu D, Baker DP, Williams KP, Chadwick K, Ling LE, Karanu FN, Bhatia M . 2001 Nat. Immunol. 2: 172–180

  • Bhatia M, Bonnet D, Wu D, Murdoch B, Wrana J, Gallacher L, Dick JE . 1999 J. Exp. Med. 189: 1139–1148

  • Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL . 1999 Science 283: 534–537

  • Blazsek I, Chagraoui J, Peault B . 2000 Blood 96: 3763–3771

  • Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH . 1998 Proc. Natl. Acad. Sci. USA 95: 2061–2066

  • Boyes J, Byfield P, Nakatani Y, Ogryzko V . 1998 Nature 396: 594–598

  • Brandon C, Eisenberg LM, Eisenberg CA . 2000 Blood 96: 4132–4141

  • Brass AL, Zhu AQ, Singh H . 1999 EMBO J 18: 977–991

  • Brazelton TR, Rossi FM, Keshet GI, Blau HM . 2000 Science 290: 1775–1779

  • Bromleigh VC, Freedman LP . 2000 Genes Dev. 14: 2581–2586

  • Broudy VC . 1997 Blood 90: 1345–1364

  • Broudy VC, Lin NL, Priestley GV, Nocka K, Wolf NS . 1996 Blood 88: 75–81

  • Bryder D, Jacobsen SE . 2000 Blood 96: 1748–1755

  • Busslinger M, Nutt SL, Rolink AG . 2000 Curr. Opin. Immunol. 12: 151–158

  • Chen H, Ray-Gallet D, Zhang P, Hetherington CJ, Gonzalez DA, Zhang DE, Moreau-Gachelin F, Tenen DG . 1995 Oncogene 11: 1549–1560

  • Chen Z, Wang ZY, Chen SJ . 1997 Pharmacol. Ther. 76: 141–149

  • Cheng T, Rodrigues N, Dombkowski D, Stier S, Scadden DT . 2000a Nat. Med. 6: 1235–1240

  • Cheng T, Rodrigues N, Shen H, Yang Y, Dombkowski D, Sykes M, Scadden DT . 2000b Science 287: 1804–1808

  • Chiang MY, Monroe JG . 1999 Blood 94: 3621–3632

  • Choi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G . 1998 Development 125: 725–732

  • Ciau-Uitz A, Walmsley M, Patient R . 2000 Cell 102: 787–796

  • Coutts M, Cui K, Davis KL, Keutzer JC, Sytkowski AJ . 1999 Blood 93: 3369–3378

  • Crispino JD, Lodish MB, MacKay JP, Orkin SH . 1999 Mol. Cell. 3: 219–228

  • Cumano A, Godin I . 2001 Curr. Opin. Immunol. 13: 166–171

  • Daga A, Podesta M, Capra MC, Piaggio G, Frassoni F, Corte G . 2000 Exp. Hematol. 28: 569–574

  • Deftos ML, Bevan MJ . 2000 Curr. Opin. Immunol. 12: 166–172

  • DeKoter RP, Singh H . 2000 Science 288: 1439–1441

  • DeKoter RP, Walsh JC, Singh H . 1998 EMBO J 17: 4456–4468

  • Drexler HG, Meyer C, Zaborski M, Uphoff CC, Quentmeier H . 1998 Leuk. Res. 22: 927–938

  • Ducos K, Panterne B, Fortunel N, Hatzfeld A, Monier MN, Hatzfeld J . 2000 J. Cell. Physiol. 184: 80–85

  • Dybedal I, Bryder D, Fossum A, Rusten LS, Jacobsen SE . 2001 Blood 98: 1782–1791

  • Egawa T, Kawabata K, Kawamoto H, Amada K, Okamoto R, Fujii N, Kishimoto T, Katsura Y, Nagasawa T . 2001 Immunity 15: 323–334

  • Elwood NJ, Zogos H, Pereira DS, Dick JE, Begley CG . 1998 Blood 91: 3756–3765

  • Engel I, Johns C, Bain G, Rivera RR, Murre C . 2001 J. Exp. Med. 194: 733–746

  • Enver T, Greaves M . 1998 Cell 94: 9–12

  • Evans CA, Pierce A, Winter SA, Spooncer E, Heyworth CM, Whetton AD . 1999 Blood 94: 1504–1514

  • Francis JM, Heyworth CM, Spooncer E, Pierce A, Dexter TM, Whetton AD . 2000 J. Biol. Chem. 275: 39137–39145

  • Fujmaki S, Harigae H, Sugawara T . 2001 Br. J. Haematol. 113: 52–57

  • Fuller J, McAdara J, Yaron Y . 1999 Blood 93: 3391–3400

  • Georgopoulos K, Bigby M, Wang J . 1994 Cell 79: 143–156

  • Giampaolo A, Sterpetti P, Bulgarini D . 1994 Blood 84: 3637–3647

  • Giannola D, Shlomchik W, Jegathesan M . 2000 J. Exp. Medicine 192: 1479–1490

  • Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW . 1994 Science 265: 1445–1447

  • Gussoni E, Soneoka Y, Strickland CD, Buzney EA, Khan MK, Flint AF, Kunkel LM, Mulligan RC . 1999 Nature 401: 390–394

  • Hao SX, Ren R . 2000 Mol. Cell. Biol. 20: 1149–1161

  • Harris KW, Hu XJ, Schultz S, Arcasoy MO, Forget BG, Clare N . 1998 Blood 92: 1219–1224

  • Hartman M, Piliponsky AM, Temkin V, Levi-Schaffer F . 2001 Blood 97: 1086–1091

  • Helgason CD, Sauvageau G, Lawrence HJ, Largman C, Humphries RK . 1996 Blood 87: 2740–2749

  • Heyworth C, Gale K, Dexter M, May G, Enver T . 1999 Genes Dev. 13: 1847–1860

  • Holtschke T, Lohler J, Kanno Y, Fehr T, Giese N, Rosenbauer F, Lou J, Knobeloch KP, Gabriele L, Waring JF, Bachmann MF, Zinkernagel RM, Morse III HC, Ozato K, Horak I . 1996 Cell 87: 307–317

  • Hsu HC, Ema H, Osawa M, Nakamura Y, Suda T, Nakauchi H . 2000 Blood 96: 3757–3762

  • Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C, Enver T . 1997 Genes Dev. 11: 774–785

  • Huang S, Brandt SJ . 2000 Mol. Cell. Biol. 20: 2248–2259

  • Huang S, Qiu Y, Shi Y, Xu Z, Brandt SJ . 2000 EMBO J. 19: 6792–6803

  • Ichikawa Y . 1970 J. Cell. Physiol. 76: 175–184

  • Ikonomi P, Rivera CE, Riordan M, Washington G, Schechter AN, Noguchi CT . 2000 Exp. Hematol. 28: 1423–1431

  • Izon DJ, Punt JA, Xu L, Karnell FG, Allman D, Myung PS, Boerth NJ, Pui JC, Koretzky GA, Pear WS . 2001 Immunity 14: 253–264

  • Jackson KA, Mi T, Goodell MA . 1999 Proc. Natl. Acad. Sci. USA 96: 14482–14486

  • Jakubowiak A, Pouponnot C, Berguido F, Frank R, Mao S, Massague J, Nimer SD . 2000 J. Biol. Chem. 275: 40282–40287

  • Just U, Stocking C, Spooncer E, Dexter TM, Ostertag W . 1991 Cell 64: 1163–1173

  • Kapur R, Cooper R, Xiao X, Weiss MJ, Donovan P, Williams DA . 1999 Blood 94: 1915–1925

  • Kapur R, Zhang L . 2001 J. Biol. Chem. 276: 1099–1106

  • Karanu FN, Murdoch B, Gallacher L, Wu DM, Koremoto M, Sakano S, Bhatia M . 2000 J. Exp. Med. 192: 1365–1372

  • Kee BL, Murre C . 1998 J. Exp. Med. 188: 699–713

  • Kelly LM, Englmeier U, Lafon I, Sieweke MH, Graf T . 2000 EMBO J. 19: 1987–1997

  • Kiger AA, White-Cooper H, Fuller MT . 2000 Nature 407: 750–754

  • Klug CA, Morrison SJ, Masek M, Hahm K, Smale ST, Weissman IL . 1998 Proc. Natl. Acad. Sci. USA 95: 657–662

  • Koipally J, Renold A, Kim J, Georgopoulos K . 1999 EMBO J. 18: 3090–3100

  • Kondo M, Scherer DC, Miyamoto T, King AG, Akashi K, Sugamura K, Weissman IL . 2000 Nature 407: 383–386

  • Kondo M, Weissman IL, Akashi K . 1997 Cell 91: 661–672

  • Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ . 2001 Cell 105: 369–377

  • Krishnaraju K, Hoffman B, Liebermann DA . 2001 Blood 97: 1298–1305

  • Krosl J, Baban S, Krosl G, Rozenfeld S, Largman C, Sauvageau G . 1998 Oncogene 16: 3403–3412

  • Krystal G, Lam V, Dragowska W, Takahashi C, Appel J, Gontier A, Jenkins A, Lam H, Quon L, Lansdorp P . 1994 J. Exp. Med. 180: 851–860

  • Lacaud G, Carlsson L, Keller G . 1998 Immunity 9: 827–838

  • Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M . 2000 Nat. Med. 6: 1229–1234

  • Lin RJ, Egan DA, Evans RM . 1999 Trends Genet. 15: 179–184

  • Liu YJ, Kanzler H, Soumelis V, Gilliet M . 2001 Nat. Immunol. 2: 585–589

  • Maeno M, Mead PE, Kelley C, Xu RH, Kung HF, Suzuki A, Ueno N, Zon LI . 1996 Blood 88: 1965–1972

  • Maguer-Satta V, Oostendorp R, Reid D, Eaves CJ . 2000 Blood 96: 4118–4123

  • Maitra S, Atchison M . 2000 Mol. Cell. Biol. 20: 1911–1922

  • Manaia A, Lemarchandel V, Klaine M, Max-Audit I, Romeo P, Dieterlen-Lievre F, Godin I . 2000 Development 127: 643–653

  • Marshall CJ, Kinnon C, Thrasher AJ . 2000 Blood 96: 1591–1593

  • Matsumura I, Kawasaki A, Tanaka H, Sonoyama J, Ezoe S, Minegishi N, Nakajima K, Yamamoto M, Kanakura Y . 2000 Blood 96: 2440–2450

  • Medvinsky A, Dzierzak E . 1996 Cell 86: 897–906

  • Meng X, Lindahl M, Hyvonen ME, Parvinen M, de Rooij DG, Hess MW, Raatikainen-Ahokas A, Sainio K, Rauvala H, Lakso M, Pichel JG, Westphal H, Saarma M, Sariola H . 2000 Science 287: 1489–1493

  • Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR . 2000 Science 290: 1779–1782

  • Montecino-Rodriguez E, Leathers H, Dorshkind K . 2001 Nat. Immunol. 2: 83–88

  • Moreau-Gachelin F, Tavitian A, Tambourin P . 1988 Nature 331: 277–280

  • Morimura T, Goitsuka R, Zhang Y, Saito I, Reth M, Kitamura D . 2000 J. Biol. Chem. 275: 36523–36531

  • Morimura T, Miyatani S, Kitamura D, Goitsuka R . 2001 J. Immunol. 166: 3277–3283

  • Mullen A, High F, Hutchins A . 2001 Science 292: 1907–1910

  • Nerlov C, Graf T . 1998 Genes Dev. 12: 2403–2412

  • Nerlov C, Querfurth E, Kulessa H, Graf T . 2000 Blood 95: 2543–2551

  • Nichogiannopoulou A, Trevisan M, Neben S, Friedrich C, Georgopoulos K . 1999 J. Exp. Med. 190: 1201–1214

  • Niwa H, Burdon T, Chambers I, Smith A . 1998 Genes Dev. 12: 2048–2060

  • Nutt SL, Busslinger M . 1999 Biol. Chem. 380: 601–611

  • Nutt SL, Heavey B, Rolink AG, Busslinger M . 1999 Nature 401: 556–562

  • Nutt SL, Urbanek P, Rolink A, Busslinger M . 1997 Genes Dev. 11: 476–491

  • O'Riordan M, Grosschedl R . 1999 Immunity 11: 21–31

  • Ogawa M, Matsuzaki Y, Nishikawa S, Hayashi S, Kunisada T, Sudo T, Kina T, Nakauchi H . 1991 J. Exp. Med. 174: 63–71

  • Oh IH, Reddy EP . 1998 Mol. Cell. Biol. 18: 499–511

  • Ohneda O, Fennie C, Zheng Z, Donahue C, La H, Villacorta R, Cairns B, Lasky LA . 1998 Blood 92: 908–919

  • Okuda T, Takeda K, Fujita Y, Nishimura M, Yagyu S, Yoshida M, Akira S, Downing JR, Abe T . 2000 Mol. Cell. Biol. 20: 319–328

  • Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR . 1996 Cell 84: 321–330

  • Ordentlich P, Lin A, Shen CP, Blaumueller C, Matsuno K, Artavanis-Tsakonas S, Kadesch T . 1998 Mol. Cell. Biol. 18: 2230–2239

  • Osawa M, Hanada K, Hamada H, Nakauchi H . 1996 Science 273: 242–245

  • Pabst T, Mueller BU, Zhang P, Radomska HS, Narravula S, Schnittger S, Behre G, Hiddemann W, Tenen DG . 2001 Nat. Genet. 27: 263–270

  • Pan Q, Simpson RU . 1999 J. Biol. Chem. 274: 8437–8444

  • Pan Q, Simpson RU . 2001 J. Endocrinol. 169: 153–159

  • Papayannopoulou T, Priestley GV, Rohde A, Peterson KR, Nakamoto B . 2000 Blood 95: 1274–1282

  • Passegue E, Jochum W, Schorpp-Kistner M, Mohle-Steinlein U, Wagner EF . 2001 Cell 104: 21–32

  • Passegue E, Wagner EF . 2000 EMBO J. 19: 2969–2979

  • Pawlak G, Grasset MF, Arnaud S, Blanchet JP, Mouchiroud G . 2000 Exp. Hematol. 28: 1164–1173

  • Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB et al . 1994 J. Exp. Med. 180: 1955–1960

  • Philips R, Ernst R, Brunk B . 2000 Science 288: 1635–1640

  • Pierelli L, Marone M, Bonanno G, Mozzetti S, Rutella S, Morosetti R, Rumi C, Mancuso S, Leone G, Scambia G . 2000 Blood 95: 3001–3009

  • Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH . 1999 Development 126: 4603–4615

  • Pui JC, Allman D, Xu L, DeRocco S, Karnell FG, Bakkour S, Lee JY, Kadesch T, Hardy RR, Aster JC, Pear WS . 1999 Immunity 11: 299–308

  • Querfurth E, Schuster M, Kulessa H, Crispino JD, Doderlein G, Orkin SH, Graf T, Nerlov C . 2000 Genes Dev. 14: 2515–2525

  • Racke FK, Wang D, Zaidi Z, Kelley J, Visvader J, Soh JW, Goldfarb AN . 2001 J. Biol. Chem. 276: 522–528

  • Radomska HS, Huettner CS, Zhang P, Cheng T, Scadden DT, Tenen DG . 1998 Mol. Cell. Biol. 18: 4301–4314

  • Radtke F, Wilson A, Stark G, Bauer M, van Meerwijk J, MacDonald HR, Aguet M . 1999 Immunity 10: 547–558

  • Raz R, Lee CK, Cannizzaro LA, d'Eustachio P, Levy DE . 1999 Proc. Natl. Acad. Sci. USA 96: 2846–2851

  • Rebel VI, Hartnett S, Hill GR, Lazo-Kallanian SB, Ferrara JL, Sieff CA . 1999 J. Exp. Med. 190: 1493–1504

  • Rekhtman N, Radparvar F, Evans T, Skoultchi AI . 1999 Genes Dev. 13: 1398–1411

  • Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey RP, Metcalf D, Begley CG . 1995 Proc. Natl. Acad. Sci. USA 92: 7075–7079

  • Robertson SM, Kennedy M, Shannon JM, Keller G . 2000 Development 127: 2447–2459

  • Rojnuckarin P, Miyakawa Y, Fox NE, Deou J, Daum G, Kaushansky K . 2001 J. Biol. Chem. 4: 4

  • Rolink AG, Nutt SL, Melchers F, Busslinger M . 1999 Nature 401: 603–606

  • Rothenberg EV . 2000 Curr. Opin. Genet. Dev. 10: 370–379

  • Sabbattini P, Lundgren M, Georgiou A, Chow C, Warnes G, Dillon N . 2001 EMBO J. 20: 2812–2822

  • Sakamaki S, Hirayama Y, Matsunaga T, Kuroda H, Kusakabe T, Akiyama T, Konuma Y, Sasaki K, Tsuji N, Okamoto T, Kobune M, Kogawa K, Kato J, Takimoto R, Koyama R, Niitsu Y . 1999 Blood 94: 1961–1970

  • Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK . 1995 Genes Dev. 9: 1753–1765

  • Schmidt M, Nagel S, Proba J, Thiede C, Ritter M, Waring JF, Rosenbauer F, Huhn D, Wittig B, Horak I, Neubauer A . 1998 Blood 91: 22–29

  • Schroeder T, Just U . 2000a Exp. Hematol. 28: 1206–1213

  • Schroeder T, Just U . 2000b EMBO J. 19: 2558–2568

  • Scott EW, Simon MC, Anastasi J, Singh H . 1994 Science 265: 1573–1577

  • Semerad CL, Poursine-Laurent J, Liu F, Link DC . 1999 Immunity 11: 153–161

  • Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, Ishida A, Fujita Y, Kothari S, Mohle R, Sauvage LR, Moore MA, Storb RF, Hammond WP . 1998 Blood 92: 362–367

  • Solanilla A, Dechanet J, El Andaloussi A, Dupouy M, Godard F, Chabrol J, Charbord P, Reiffers J, Nurden AT, Weksler B, Moreau JF, Ripoche J . 2000 Blood 95: 3758–3764

  • Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH . 2000 Cell 100: 655–669

  • Tamura T, Mancini A, Joos H, Koch A, Hakim C, Dumanski J, Weidner KM, Niemann H . 1999 Oncogene 18: 6488–6495

  • Tamura T, Nagamura-Inoue T, Shmeltzer Z, Kuwata T, Ozato K . 2000 Immunity 13: 155–165

  • Thorsteinsdottir U, Sauvageau G, Humphries RK . 1999 Blood 94: 2605–2612

  • Ting CN, Olson MC, Barton KP, Leiden JM . 1996 Nature 384: 474–478

  • Tonelli R, Scardovi AL, Pession A, Strippoli P, Bonsi L, Vitale L, Prete A, Locatelli F, Bagnara GP, Paolucci G . 2000 Hum. Genet. 107: 225–233

  • Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST . 2001 Genes Dev. 15: 1817–1832

  • Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH . 1994 Nature 371: 221–226

  • Tsai SF, Strauss E, Orkin SH . 1991 Genes Dev. 5: 919–931

  • Tsang AP, Visvader JE, Turner CA, Fujiwara Y, Yu C, Weiss MJ, Crossley M, Orkin SH . 1997 Cell 90: 109–119

  • Tsuzuki S, Towatari M, Saito H, Enver T . 2000 Mol. Cell. Biol. 20: 6276–6286

  • Uchida M, Kirito K, Shimizu R, Miura Y, Ozawa K, Komatsu N . 2001 Int. J. Hematol. 73: 78–83

  • Vannucchi AM, Paoletti F, Linari S, Cellai C, Caporale R, Ferrini PR, Sanchez M, Migliaccio G, Migliaccio AR . 2000 Blood 95: 2559–2568

  • Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S, Pear WS, Bernstein ID . 2000 Nat. Med. 6: 1278–1281

  • Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K . 1996 Immunity 5: 537–549

  • Wang X, Scott E, Sawyers CL, Friedman AD . 1999 Blood 94: 560–571

  • Winandy S, Wu L, Wang JH, Georgopoulos K . 1999 J. Exp. Med. 190: 1039–1048

  • Wu L, Antica M, Johnson GR, Scollay R, Shortman K . 1991 J. Exp. Med. 174: 1617–1627

  • Yamada Y, Warren AJ, Dobson C, Forster A, Pannell R, Rabbitts TH . 1998 Proc. Natl. Acad. Sci. USA 95: 3890–3895

  • Yamagata T, Mitani K, Oda H, Suzuki T, Honda H, Asai T, Maki K, Nakamoto T, Hirai H . 2000 EMBO J. 19: 4676–4687

  • Yang FC, Watanabe S, Tsuji K, Xu MJ, Kaneko A, Ebihara Y, Nakahata T . 1998 Blood 92: 4632–4640

  • Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG . 1997 Proc. Natl. Acad. Sci. USA 94: 569–574

  • Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z . 1999 Proc. Natl. Acad. Sci. USA 96: 8705–8710

  • Zhang P, Zhang X, Iwama A, Yu C, Smith KA, Mueller BU, Narravula S, Torbett BE, Orkin SH, Tenen DG . 2000 Blood 96: 2641–2648

  • Zhao Y, Lin Y, Zhan Y, Yang G, Louie J, Harrison DE, Anderson WF . 2000 Blood 96: 3016–3022

  • Zhou Y, Lim KC, Onodera K, Takahashi S, Ohta J, Minegishi N, Tsai FY, Orkin SH, Yamamoto M, Engel JD . 1998 EMBO J. 17: 6689–6700

  • Zhuang Y, Barndt RJ, Pan L, Kelley R, Dai M . 1998 Mol. Cell. Biol. 18: 3340–3349

  • Ziegler BL, Valtieri M, Porada GA, De Maria R, Muller R, Masella B, Gabbianelli M, Casella I, Pelosi E, Bock T, Zanjani ED, Peschle C . 1999 Science 285: 1553–1558

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We thank Diane Giannola for assistance in graphical design.

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Zhu, J., Emerson, S. Hematopoietic cytokines, transcription factors and lineage commitment. Oncogene 21, 3295–3313 (2002). https://doi.org/10.1038/sj.onc.1205318

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Keywords

  • transcription factor
  • cytokines
  • hematopoiesis

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