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Selective loss of chromosome 11 in pheochromocytomas associated with the VHL syndrome

Oncogene volume 21, pages 1117–1122 (2002)Cite this article

Abstract

By using comparative genomic hybridization (CGH), we characterized the genetic profiles of 36 VHL-related pheochromocytomas. We then compared the results with those of sporadic and MEN 2-related pheochromocytomas. In 36 VHL-related tumors, loss of chromosome 3 and chromosome 11 were found in 34 tumors (94%) and 31 tumors (86%), respectively. There was significant concordance of deletions in chromosomes 3 and 11 (Kappa=0.64, P=0.0095), suggesting that they are involved in two different but necessary and complementary genetic pathways. The loss of chromosome 11 appeared to be specific for VHL-related pheochromocytoma as it was not present in any of the 10 VHL-related CNS hemangioblastomas studied and was significantly less common when compared with (a) sporadic pheochromocytomas from previously published results (13%; P=<0.0001), and (b) MEN 2-related pheochromocytomas from this and previously published studies (30%; P=0.0012). In summary, this is the first report of a novel consistent genetic alteration that is selected and specific for VHL-related pheochromocytoma, besides the two hits of the VHL gene.

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References

  • Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, van der Mey A, Taschner PEM, Rubinstein WS, Myers EN, Richard CW III, Cornelisse CJ, Devilee P, Devlin B . 2000 Science 287: 848–850

  • Bender BU, Gutsche M, Gläsker S, Müller B, Kirste G, Eng C, Neumann HPH . 2000 J. Clin. Endocrinol. Metab. 85: 4568–4574

  • Benn DE, Dwight T, Richardson AL, Delbridge L, Bambach CP, Stowasser M, Gordon RD, Marsh DJ, Robinson BG . 2000 Cancer Res. 60: 7048–7051

  • Brauch H, Kishida T, Glavac D, Chen F, Pausch F, Hofler H, Latif F, Lerman MI, Zbar B, Neumann HPH . 1995 Hum. Genet. 95: 551–556

  • Canzian F, Salovaara R, Hemminki A, Kristo P, Chadwick RB, Aaltonen LA, de la Chapelle A . 1996 Cancer Res. 56: 3331–3337

  • Chen F, Kishida T, Yao M, Hustad T, Glavac D, Dean M, Gnarra JR, Orcutt ML, Duh FM, Glenn G, Green J, Hsia YE, Lamiell J, Li H, Wei MW, Schmidt L, Tory K, Kuzmin I, Stackhouse T, Latif F, Linehan WM, Lerman M, Zbar B . 1995 Hum. Mutat. 5: 66–75

    Article  CAS  Google Scholar 

  • Dannenberg H, Speel EJM, Zhao J, Saremaslani P, van Der Harst E, Roth J, Heitz PU, Bonjer HJ, Dinjens WNM, Mooi W, Komminoth P, de Krijger RR . 2000 Am. J. Pathol. 157: 353–359

  • Edström E, Mahlamäki E, Nord B, Kjellman M, Karhu R, Höög A, Goncharov N, Teh BT, Kallioniemi O-P, Bäckdahl M, Larsson C . 2000 Am. J. Pathol. 156: 651–659

  • Farnebo F, Kytöla S, Teh BT, Dwight T, Wong FK, Höög A, Elvius M, Wassif W, Thompson NW, Farnebo L-O, Sandelin K, Larsson C . 1999 J. Clin. Endocrinol. Metab. 84: 3775–3780

  • Fearon ER, Vogelstein B . 1990 Cell 61: 759–767

    Article  CAS  Google Scholar 

  • Gimm O, Armanios M, Dziema H, Neumann HP, Eng C . 2000 Cancer Res. 60: 6822–6825

  • Iliopoulos O, Levy AP, Jiang C, Kaelin WG, Goldberg MA . 1996 Proc. Natl. Acad. Sci. USA 93: 10595–10599

  • Kallioniemi A, Kallioniemi O-P, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D . 1992 Science 258: 818–821

    Article  CAS  Google Scholar 

  • Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin Jr WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW . 1999 Science 284: 657–661

  • Kwabi-Addo B, Girl D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M . 2001 Proc. Natl. Acad. Sci. USA 98: 11563–11568

  • Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi P, Walther MM, Weng Y, Duan DS, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, Paslier D, Chumakov I, Cohen D, Chinault AC, Maher ER, Linehan WM, Zbar B, Lerman MI . 1993 Science 260: 1317–1320

    Article  CAS  Google Scholar 

  • Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ . 1999 Nature 399: 271–275

    Article  CAS  Google Scholar 

  • Ramus SJ, Bobrow LG, Pharoah PD, Finnigan DS, Fishman A, Altaras M, Harrington PA, Gayther SA, Ponder BA, Friedman LS . 1999 Genes Chromosomes Cancer 25: 91–96

  • Schussheim DH, Skarulis MC, Agarwal SK, Simonds WF, Burns AL, Spiegel AM, Marx SJ . 2001 Trends Endocrinol. Metab. 12: 173–178

  • Smith PD, Crossland S, Parker G, Osin P, Brooks L, Waller J, Philp E, Crompton MR, Gusterson BA, Allday MJ, Crook T . 1999 Oncogene 15: 2451–2459

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden

    Weng Onn Lui, Catharina Larsson & Bin Tean Teh

  2. Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, 49503, Michigan, MI, USA

    Jindong Chen, Casey Madura, Sok Kean Khoo & Bin Tean Teh

  3. Department of Nephrology and Hypertension, Albert-Ludwigs-University, Freiburg, Germany

    Sven Gläsker, Bernhad U Bender & Harmut PH Neumann

  4. Laboratory of Analytical, Cellular and Molecular Microscopy, Van Andel Research Institute, Grand Rapids, 49503, Michigan, MI, USA

    Eric Kort

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  1. Weng Onn Lui
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Correspondence to Harmut PH Neumann.

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Lui, W., Chen, J., Gläsker, S. et al. Selective loss of chromosome 11 in pheochromocytomas associated with the VHL syndrome. Oncogene 21, 1117–1122 (2002). https://doi.org/10.1038/sj.onc.1205149

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