Abstract
Crk family adaptors are widely expressed and mediate the timely formation of signal transduction protein complexes upon a variety of extracellular stimuli, including various growth and differentiation factors. Selective formation of multi-protein complexes by the Crk and Crk-like (CRKL) proteins depends on specific motifs recognized by their SH2 and SH3 domains. In the case of the first SH3 domains [SH3(1)] a P-x-x-P-x-K motif is crucial for highly selective binding, while the SH2 domains prefer motifs which conform to the consensus pY-x-x-P. Crk family proteins are involved in the relocalization and activation of several different effector proteins which include guanine nucleotide releasing proteins like C3G, protein kinases of the Abl- and GCK-families and small GTPases like Rap1 and Rac. Crk-type proteins have been found not only in vertebrates but also in flies and nematodes. Major insight into the function of Crk within organisms came from the genetic model organism C. elegans, where the Crk-homologue CED-2 regulates cell engulfment and phagocytosis. Other biological outcomes of the Crk-activated signal transduction cascades include the modulation of cell adhesion, cell migration and immune cell responses. Crk family adaptors also appear to play a role in mediating the action of human oncogenes like the leukaemia-inducing Bcr–Abl protein. This review summarizes some key findings and highlights recent insights and open questions.
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References
Ahmad S, Alsayad YM, Druker BJ, Platanias LC . 1997 J. Biol. Chem. 272: 29991–29994
Akagi T, Shishido T, Murata K, Hanafusa H . 2000 Proc. Natl. Acad. Sci. USA 97: 7290–7295
Albert ML, Kim JI, Birge RB . 2000 Nat. Cell. Biol. 2: 899–905
Alsayed Y, Uddin S, Ahmad S, Majchrzak B, Druker BJ, Fish EN, Platanias LC . 2000 J. Immunol. 164: 1800–1806
Anai M, Ono H, Funaki M, Fukushima Y, Inukai K, Ogihara T, Sakoda H, Onishi Y, Yazaki Y, Kikuchi M, Oka Y, Asano T . 1998 J. Biol. Chem. 273: 29686–29692
Andoniou CE, Thien CB, Langdon WY . 1996 Oncogene 12: 1981–1989
Anneren C, Reedquist KA, Bos JL, Welsh M . 2000 J. Biol. Chem. 275: 29153–29161
Araki E, Lipes MA, Patti ME, Bruning JC, Haag III B, Johnson RS, Kahn CR . 1994 Nature 372: 186–190
Asha H, de Ruiter ND, Wang MG, Hariharan IK . 1999 EMBO J. 18: 605–615
Astier A, Manie SN, Law SF, Canty T, Haghayghi N, Druker BJ, Salgia R, Golemis EA, Freedman AS . 1997 Leuk. Lymphoma 28: 65–72
Barber DL, Mason JM, Fukazawa T, Reedquist KA, Druker BJ, Band H, D'Andrea AD . 1997 Blood 89: 3166–3174
Barila D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G . 2000 EMBO J. 19: 273–281
Baskaran R, Wood LD, Whitaker LL, Canman CE, Morgan SE, Xu Y, Barlow C, Baltimore D, Wynshaw-Boris A, Kastan MB, Wang JY . 1997 Nature 387: 516–519
Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR . 2000 Nature 407: 202–207
Beitner-Johnson D, LeRoith D . 1995 J. Biol. Chem. 270: 5187–5190
Beitner-Johnson D, Blakesley VA, Shen-Orr Z, Jimenez M, Stannard B, Wang LM, Pierce J, LeRoith D . 1996 J. Biol. Chem. 271: 9287–9290
Bevan P . 2001 J. Cell. Sci. 114: 1429–1430
Bhat A, Johnson KJ, Oda T, Corbin AS, Druker BJ . 1998 J. Biol. Chem. 273: 32360–32368
Birge RB, Fajardo JE, Mayer BJ, Hanafusa H . 1992 J. Biol. Chem. 267: 10588–10595
Birge RB, Fajardo JE, Reichman C, Shoelson SE, Songyang Z, Cantley LC, Hanafusa H . 1993 Mol. Cell. Biol. 13: 4648–4656
Birge RB, Knudsen BS, Besser D, Hanafusa H . 1996 Genes Cells 1: 595–613
Bishop AL, Hall A . 2000 Biochem. J. 348: 241–255
Blakesley VA, Beitner-Johnson D, Van Brocklyn JR, Rani S, Shen-Orr Z, Stannard BS, Spiegel S, LeRoith D . 1997 J. Biol. Chem. 272: 16211–16215
Blelloch R, Newman C, Kimble J . 1999 Curr. Opin. Cell. Biol. 11: 608–613
Bocciardi R, Mograbi B, Pasini B, Borrello MG, Pierotti MA, Bourget I, Fischer S, Romeo G, Rossi B . 1997 Oncogene 15: 2257–2265
Boettner B, Govek EE, Cross J, Van Aelst L . 2000 Proc. Natl. Acad. Sci. USA 97: 9064–9069
Bork P, Schultz J, Ponting CP . 1997 Trends Biochem. Sci. 22: 296–298
Boussiotis VA, Freeman GJ, Berezovskaya A, Barber DL, Nadler LM . 1997 Science 278: 124–128
Bouton AH . 2001 Oncogene 20: 6448–6458
Brauweiler AM, Tamir I, Cambier JC . 2000 Immunol. Rev. 176: 69–74
Brinkman A, van der Flier S, Kok EM, Dorssers LC . 2000 J. Natl. Cancer Inst. 92: 112–120
Brown A, Browes C, Mitchell M, Montano X . 2000 Oncogene 19: 3032–3040
Buday L, Khwaja A, Sipeki S, Farago A, Downward J . 1996 J. Biol. Chem. 271: 6159–6163
Buday L . 1999 Biochim. Biophys. Acta 1422: 187–204
Buensuceso CS, O'Toole TE . 2000 J. Biol. Chem. 275: 13118–13125
Burack WR, Shaw AS . 2000 Curr. Opin. Cell. Biol. 12: 211–216
Burks DJ, White MF . 2001 Diabetes 50: S140–S145
Butler AA, Blakesley VA, Koval A, deJong R, Groffen J, LeRoith D . 1997 J. Biol. Chem. 272: 27660–27664
Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, LeRoith D . 1998 Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 121: 19–26
Cai D, Clayton LK, Smolyar A, Lerner A . 1999 J. Immunol. 163: 2104–2112
Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B . 1997 Cell 88: 197–204
Cary LA, Guan JL . 1999 Front Biosci. 4: D102–D113
Casamassima A, Rozengurt E . 1997 J. Biol. Chem. 272: 9363–9370
Chan AC, Iwashima M, Turck CW, Weiss A . 1992 Cell 71: 649–662
Cheresh DA, Leng J, Klemke RL . 1999 J. Cell. Biol. 146: 1107–1116
Chernock RD, Cherla RP, Ganju RK . 2001 Blood 97: 608–615
Chiang SH, Baumann CA, Kanzaki M, Thurmond DC, Watson RT, Neudauer CL, Macara IG, Pessin JE, Saltiel AR . 2001 Nature 410: 944–948
Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O . 1997 Biochem. Biophys. Res. Commun. 239: 412–417
Cho SY, Klemke RL . 2000 J. Cell. Biol. 149: 223–236
Chu DH, Morita CT, Weiss A . 1998 Immunol. Rev. 165: 167–180
Chung S, Gumienny TL, Hengartner MO, Driscoll M . 2000 Nat. Cell. Biol. 2: 931–937
Cicchetti P, Mayer BJ, Thiel G, Baltimore D . 1992 Science 257: 803–806
Cicchetti P, Ridley AJ, Zheng Y, Cerione RA, Baltimore D . 1995 EMBO J. 14: 3127–3135
Clyde-Smith J, Silins G, Gartside M, Grimmond S, Etheridge M, Apolloni A, Hayward N, Hancock JF . 2000 J. Biol. Chem. 275: 32260–32267
Cody WL, Lin Z, Panek RL, Rose DW, Rubin JR . 2000 Curr. Pharm. Des. 6: 59–98
Coffer PJ, Koenderman L, de Groot RP . 2000 Oncogene 19: 2511–2522
Cohen GB, Ren R, Baltimore D . 1995 Cell 80: 237–248
Cussac D, Vidal M, Leprince C, Liu WQ, Cornille F, Tiraboschi G, Roques BP, Garbay C . 1999 FASEB J. 13: 31–38
Czyzyk J, Leitenberg D, Taylor T, Bottomly K . 2000 Mol. Cell. Biol. 20: 8740–8747
Dawid IB, Breen JJ, Toyama R . 1998 Trends Genet. 14: 156–162
de Jong R, Haataja L, Voncken JW, Heisterkamp N, Groffen J . 1995a Oncogene 11: 1469–1474
de Jong R, ten Hoeve J, Heisterkamp N, Groffen J . 1995b J. Biol. Chem. 270: 21468–21471
de Jong R, ten Hoeve J, Heisterkamp N, Groffen J . 1997 Oncogene 14: 507–513
de Jong R, van Wijk A, Heisterkamp N, Groffen J . 1998 Oncogene 17: 2805–2810
Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD . 1998 J. Biol. Chem. 273: 4827–4830
Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F . 2000 Neuron 28: 115–127
Dodelet VC, Pazzagli C, Zisch AH, Hauser CA, Pasquale EB . 1999 J. Biol. Chem. 274: 31941–31946
Dolfi F, Garcia-Guzman M, Ojaniemi M, Nakamura H, Matsuda M, Vuori K . 1998 Proc. Natl. Acad. Sci. USA 95: 15394–15399
Druker BJ, Lydon NB . 2000 J. Clin. Invest. 105: 3–7
Du J, Alsayed YM, Xin F, Ackerman SJ, Platanias LC . 2000 J. Biol. Chem. 275: 33167–33175
Dubiel W, Gordon C . 1999 Curr. Biol. 9: R554–R557
Dugan LL, Kim JS, Zhang Y, Bart RD, Sun Y, Holtzman DM, Gutmann DH . 1999 J. Biol. Chem. 274: 25842–25848
Eijkelenboom AP, Lutzke RA, Boelens R, Plasterk RH, Kaptein R, Hard K . 1995 Nat. Struct. Biol. 2: 807–810
Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC . 1999 Oncogene 18: 1147–1156
Erdreich-Epstein A, Liu M, Liu Y, Durden DL . 1997 Exp. Cell Res. 237: 288–295
Erickson MR, Galletta BJ, Abmayr SM . 1997 J. Cell. Biol. 138: 589–603
Escalante M, Courtney J, Chin WG, Teng KK, Kim JI, Fajardo JE, Mayer BJ, Hempstead BL, Birge RB . 2000 J. Biol. Chem. 275: 24787–24797
Evans EK, Lu W, Strum SL, Mayer BJ, Kombluth S . 1997 EMBO J. 16: 230–241
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM . 1999 N. Engl. J. Med. 341: 164–172
Fantin VR, Wang Q, Lienhard GE, Keller SR . 2000 Am. J. Physiol. Endocrinol. Metab. 278: E127–E133
Feller SM, Ren R, Hanafusa H, Baltimore D . 1994a Trends Biochem. Sci. 19: 453–458
Feller SM, Knudsen B, Hanafusa H . 1994b EMBO J. 13: 2341–2351
Feller SM, Knudsen B, Hanafusa H . 1995 Oncogene 10: 1465–1473
Feller SM, Posern G, Voss J, Kardinal C, Sakkab D, Zheng J, Knudsen BS . 1998 J. Cell. Physiol. 177: 535–552
Fish EN, Uddin S, Korkmaz M, Majchrzak B, Druker BJ, Platanias LC . 1999 J. Biol. Chem. 274: 571–573
Fukui Y, Kornbluth S, Jong SM, Wang LH, Hanafusa H . 1989 Oncogene Res. 4: 283–292
Furge KA, Zhang YW, Vande Woude GF . 2000 Oncogene 19: 5582–5589
Galletta BJ, Niu XP, Erickson MR, Abmayr SM . 1999 Gene. 228: 243–252
Garcia-Guzman M, Dolfi F, Zeh K, Vuori K . 1999 Oncogene 18: 7775–7786
Garcia-Guzman M, Larsen E, Vuori K . 2000 Oncogene 19: 4058–4065
Gelkop S, Isakov N . 1999 J. Biol. Chem. 274: 21519–21527
Gesbert F, Garbay C, Bertoglio J . 1998a J. Biol. Chem. 273: 3986–3993
Gesbert F, Guenzi C, Bertoglio J . 1998b J. Biol. Chem. 273: 18273–18281
Giancotti FG . 1997 Curr. Opin. Cell. Biol. 9: 691–700
Giancotti FG, Ruoslahti E . 1999 Science 285: 1028–1032
Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, Sbraccia P, Borboni P, Lauro R, Sesti G . 2000 Diabetes Metab. Res. Rev. 16: 434–441
Gorina S, Pavletich NP . 1996 Science 274: 1001–1005
Gotoh T, Hattori S, Nakamura S, Kitayama H, Noda M, Takai Y, Kaibuchi K, Matsui H, Hatase O, Takahashi H, Kurata T, Matsuda M . 1995 Mol. Cell. Biol. 15: 6746–6753
Gotoh T, Niino Y, Tokuda M, Hatase O, Nakamura S, Matsuda M, Hattori S . 1997 J. Biol. Chem. 272: 18602–18607
Gotoh T, Cai D, Tian X, Feig LA, Lerner A . 2000 J. Biol. Chem. 275: 30118–30123
Grewal SS, Horgan AM, York RD, Withers GS, Banker GA, Stork PJ . 2000 J. Biol. Chem. 275: 3722–3728
Grumbach IM, Mayer IA, Uddin S, Lekmine F, Majchrzak B, Yamauchi H, Fujita S, Druker B, Fish EN, Platanias LC . 2001 Br. J. Haematol. 112: 327–336
Gu H, Pratt JC, Burakoff SJ, Neel BG . 1998 Mol. Cell. 2: 729–740
Guerrero C, Fernandez-Medarde A, Rojas JM, Font de Mora J, Esteban LM, Santos E . 1998 Oncogene 16: 613–624
Gupta N, Scharenberg AM, Fruman DA, Cantley LC, Kinet JP, Long EO . 1999 J. Biol. Chem. 274: 7489–7494
Guris DL, Fantes J, Tara D, Druker BJ, Imamoto A . 2001 Nat. Genet 27: 293–298
Gustafson TA, He W, Craparo A, Schaub CD, O'Neill TJ . 1995 Mol. Cell. Biol. 15: 2500–2508
Hamasaki K, Mimura T, Morino N, Furuya H, Nakamoto T, Aizawa S, Morimoto C, Yazaki Y, Hirai H, Nojima Y . 1996 Biochem. Biophys. Res. Commun. 222: 338–343
Hanks SK, Polte TR . 1997 Bioessays 19: 137–145
Hansen K, Ronnstrand L, Claesson-Welsh L, Heldin CH . 1997 FEBS Lett. 409: 195–200
Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M . 1996 Mol. Cell. Biol. 16: 1770–1776
Hashimoto Y, Katayama H, Kiyokawa E, Ota S, Kurata T, Gotoh N, Otsuka N, Shibata M, Matsuda M . 1998 J. Biol. Chem. 273: 17186–17191
He W, O'Neill TJ, Gustafson TA . 1995 J. Biol. Chem. 270: 23258–23262
Hehner SP, Hofmann TG, Dienz O, Droge W, Schmitz ML . 2000 J. Biol. Chem. 275: 18160–18171
Hemmeryckx B, van Wijk A, Reichert A, Kaartinen V, de Jong R, Pattengale PK, Gonzalez-Gomez I, Groffen J, Heisterkamp N . 2001 Cancer Res. 61: 1398–1405
Hempstead BL, Birge RB, Fajardo JE, Glassman R, Mahadeo D, Kraemer R, Hanafusa H . 1994 Mol. Cell. Biol. 14: 1964–1971
Hibi M, Hirano T . 2000 Leuk. Lymphoma. 37: 299–307
Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ . 1996 Nature 379: 560–564
Honda H, Oda H, Nakamoto T, Honda Z, Sakai R, Suzuki T, Saito T, Nakamura K, Nakao K, Ishikawa T, Katsuki M, Yazaki Y, Hirai H . 1998 Nat. Genet 19: 361–365
Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH . 1996 Genes Dev. 10: 2251–2264
Hunter AJ, Shimizu Y . 1997 J. Immunol. 159: 4806–4814
Ichiba T, Kuraishi Y, Sakai O, Nagata S, Groffen J, Kurata T, Hattori S, Matsuda M . 1997 J. Biol. Chem. 272: 22215–22220
Ichiba T, Hashimoto Y, Nakaya M, Kuraishi Y, Tanaka S, Kurata T, Mochizuki N, Matsuda M . 1999 J. Biol. Chem. 274: 14376–14381
Ikeda M, Koyama S, Okazaki M, Dohi K, Kikuchi A . 1995 FEBS Lett. 375: 37–40
Imaizumi T, Araki K, Miura K, Araki M, Suzuki M, Terasaki H, Yamamura K . 1999 Biochem. Biophys. Res. Commun. 266: 569–574
Ingham RJ, Krebs DL, Barbazuk SM, Turck CW, Hirai H, Matsuda M, Gold MR . 1996 J. Biol. Chem. 271: 32306–32314
Ishimaru S, Williams R, Clark E, Hanafusa H, Gaul U . 1999 EMBO J. 18: 145–155
Ito N, Wernstedt C, Engstrom U, Claesson-Welsh L . 1998 J. Biol. Chem. 273: 23410–23418
Ito Y, Pandey P, Sathyanarayana P, Ling P, Rana A, Weichselbaum R, Tan TH, Kufe D, Kharbanda S . 2001 J. Biol. Chem. 276: 18130–18138
Itoh M, Yoshida Y, Nishida K, Narimatsu M, Hibi M, Hirano T . 2000 Mol. Cell. Biol. 20: 3695–3704
Izadi KD, Erdreich-Epstein A, Liu Y, Durden DL . 1998 Exp. Cell. Res. 245: 330–342
Jentsch S, Pyrowolakis G . 2000 Trends Cell. Biol. 10: 335–342
Jin S, Zhai B, Qiu Z, Wu J, Lane MD, Liao K . 2000 J. Biol. Chem. 275: 34344–34352
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC . 1999 Science 286: 309–312
Jones N, Dumont DJ . 1998 Oncogene 17: 1097–1108
Kain KH, Klemke RL . 2001 J. Biol. Chem. 276: 16185–16192
Kang H, Freund C, Duke-Cohan JS, Musacchio A, Wagner G, Rudd CE . 2000 EMBO J. 19: 2889–2899
Kao SC, Jaiswal RK, Kolch W, Landreth GE . 2001 J. Biol. Chem. 276: 18169–18177
Kardinal C, Konkol B, Schulz A, Posern G, Lin H, Adermann K, Eulitz M, Estrov Z, Talpaz M, Arlinghaus RB, Feller SM . 2000 FASEB J. 14: 1529–1538
Kardinal C, Konkol B, Lin H, Eulitz M, Schmidt EK, Estrov Z, Talpaz M, Arlinghaus RB, Feller SM . 2001 Blood in press
Katayama H, Hashimoto Y, Kiyokawa E, Nakaya M, Sakamoto A, Machinami R, Kurata T, Mochizuki N, Matsuda M . 1999 Jpn. J. Cancer Res. 90: 1096–1103
Khwaja A, Hallberg B, Warne PH, Downward J . 1996 Oncogene 12: 2491–2498
Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NN . 1996 EMBO J. 15: 7013–7025
Kirsch KH, Georgescu MM, Hanafusa H . 1998 J. Biol. Chem. 273: 25673–25679
Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME . 1997 Nat. Struct. Biol. 4: 739–743
Kiyokawa E, Mochizuki N, Kurata T, Matsuda M . 1997 Crit. Rev. Oncog. 8: 329–342
Kiyokawa E, Hashimoto Y, Kobayashi S, Sugimura H, Kurata T, Matsuda M . 1998 Genes Dev. 12: 3331–3336
Kizaka-Kondoh S, Matsuda M, Okayama H . 1996 Proc. Natl. Acad. Sci. USA 93: 12177–12182
Klemke RL, Leng J, Molander R, Brooks PC, Vuori K, Cheresh DA . 1998 J. Cell. Biol. 140: 961–972
Knudsen BS, Feller SM, Hanafusa H . 1994 J. Biol. Chem. 269: 32781–32787
Knudsen BS, Zheng J, Feller SM, Mayer JP, Burrell SK, Cowburn D, Hanafusa H . 1995 EMBO J. 14: 2191–2198
Kobayashi S, Shirai T, Kiyokawa E, Mochizuki N, Matsuda M, Fukui Y . 2001 Biochem. J. 354: 73–78
Koleske AJ, Gifford AM, Scott ML, Nee M, Bronson RT, Miczek KA, Baltimore D . 1998 Neuron 21: 1259–1272
Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ . 1999 Leuk. Lymphoma 33: 119–126
Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J . 1997 Cell 89: 693–702
Koval AP, Blakesley VA, Roberts Jr CT, Zick Y, LeRoith D . 1998a Biochem. J. 330: 923–932
Koval AP, Karas M, Zick Y, LeRoith D . 1998b J. Biol. Chem. 273: 14780–14787
Krawczyk C, Bachmaier K, Sasaki T, Jones GR, Snapper BS, Bouchard D, Kozieradzki I, Ohashi SP, Alt WF, Penninger MJ . 2000 Immunity 13: 463–473
Kuriyan J, Cowburn D . 1997 Annu. Rev. Biophys. Biomol. Struct. 26: 259–288
Kurzchalia TV, Parton RG . 1999 Curr. Opin. Cell. Biol. 11: 424–431
Kyriakis JM . 1999 J. Biol. Chem. 274: 5259–5262
Lafont F, Simons K . 2001 Proc. Natl. Acad. Sci. USA 98: 3180–3184
Lamorte L, Kamikura DM, Park M . 2000 Oncogene 19: 5973–5981
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann, L, Lehoczky, J, LeVine, R, McEwan, P, McKernan, K, Meldrim, J, Mesirov, JP, Miranda, C, Morris, W, Naylor, J, Raymond, C, Rosetti, M, Santos, R, Sheridan, A, Sougnez, C, Stange-Thomann, N, Stojanovic, N, Subramanian, A, Wyman, D, Rogers, J, Sulston, J, Ainscough, R, Beck, S, Bentley, D, Burton, J, Clee, C, Carter, N, Coulson, A, Deadman, R, Deloukas, P, Dunham, A, Dunham, I, Durbin, R, French, L, Grafham, D, Gregory, S, Hubbard, T, Humphray, S, Hunt, A, Jones, M, Lloyd, C, McMurray, A, Matthews, L, Mercer, S, Milne, S, Mullikin, JC, Mungall, A, Plumb, R, Ross, M, Shownkeen, R, Sims, S, Waterston, RH, Wilson, RK, Hillier, LW, McPherson, JD, Marra, MA, Mardis, ER, Fulton, LA, Chinwalla, AT, Pepin, KH, Gish, WR, Chissoe, SL, Wendl, MC, Delehaunty, KD, Miner, TL, Delehaunty, A, Kramer, JB, Cook, LL, Fulton, RS, Johnson, DL, Minx, PJ, Clifton, SW, Hawkins, T, Branscomb, E, Predki, P, Richardson, P, Wenning, S, Slezak, T, Doggett, N, Cheng, JF, Olsen, A, Lucas, S, Elkin, C, Uberbacher, E, Frazier, M et al. 2001 Nature 409: 860–921
Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP . 2000 Nature 408: 374–377
Larsson H, Klint P, Landgren E, Claesson-Welsh L . 1999 J. Biol. Chem. 274: 25726–25734
Lemay S, Davidson D, Latour S, Veillette A . 2000 Mol. Cell. Biol. 20: 2743–2754
Levkowitz G, Waterman H, Ettenberg SA, Katz M, Tsygankov AY, Alroy I, Lavi S, Iwai K, Reiss Y, Ciechanover A, Lipkowitz S, Yarden Y . 1999 Mol. Cell. 4: 1029–1040
Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM . 2001 Oncogene 20: 1052–1062
Li B, Boast S, de los Santos K, Schieren I, Quiroz M, Teitelbaum SL, Tondravi MM, Goff SP . 2000a Nat. Genet. 24: 304–308
Li E, Stupack DG, Brown SL, Klemke R, Schlaepfer DD, Nemerow GR . 2000b J. Biol. Chem. 275: 14729–14735
Li W, She H . 2000 Histol. Histopathol. 15: 947–955
Li W . 2001 Oncogene 20: 6403–6417
Liebl EC, Forsthoefel DJ, Franco LS, Sample SH, Hess JE, Cowger JA, Chandler MP, Shupert AM, Seeger MA . 2000 Neuron 26: 107–118
Lin H, Martelli MP, Bierer BE . 2001 Int. Immunol. 13: 13–22
Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH . 1999 Mol. Cell. Biol. 19: 1359–1368
Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Wange RL, Tan TH . 2001 J. Biol. Chem. 276: 18908–18914
Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A . 2000 Immunity 12: 399–408
Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH . 1999a Nature 402: 676–681
Liu SC, Wang Q, Lienhard GE, Keller SR . 1999b J. Biol. Chem. 274: 18093–18099
Liu QA, Hengartner MO . 1999 Ann. NY Acad. Sci. 887: 92–104
Liu E, Thant AA, Kikkawa F, Kurata H, Tanaka S, Nawa A, Mizutani S, Matsuda S, Hanafusa H, Hamaguchi M . 2000 Cancer Res. 60: 2361–2364
Liu SK-W, Berry DM, McGlade CJ . 2001 Oncogene 20: 6284–6290
Lock LS, Royal I, Naujokas MA, Park M . 2000 J. Biol. Chem. 275: 31536–31545
Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM . 1995 Biochemistry 34: 9826–9833
Lu L, Anneren C, Reedquist KA, Bos JL, Welsh M . 2000 Exp. Cell. Res. 259: 370–377
Lucas DM, Rohrschneider LR . 1999 Blood 93: 1922–1933
Lupher Jr ML, Rao N, Eck MJ, Band H . 1999 Immunol. Today 20: 375–382
Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S . 1995 FEBS Lett. 377: 243–248
Madaule P, Eda M, Watanabe N, Fujisawa K, Matsuoka T, Bito H, Ishizaki T, Narumiya S . 1998 Nature 394: 491–494
Madaule P, Furuyashiki T, Eda M, Bito H, Ishizaki T, Narumiya S . 2000 Microsc. Res. Tech. 49: 123–126
Maru Y, Witte ON, Shibuya M . 1996 Exp. Cell. Res. 229: 438–445
Matsuda M, Mayer BJ, Fukui Y, Hanafusa H . 1990 Science 248: 1537–1539
Matsuda M, Mayer BJ, Hanafusa H . 1991 Mol. Cell. Biol. 11: 1607–1613
Matsuda M, Tanaka S, Nagata S, Kojima A, Kurata T, Shibuya M . 1992 Mol. Cell. Biol. 12: 3482–3489
Matsuda M, Hashimoto Y, Muroya K, Hasegawa H, Kurata T, Tanaka S, Nakamura S, Hattori S . 1994 Mol. Cell. Biol. 14: 5495–5500
May RC . 2001 Trends Cell. Biol. 11: 150
Mayer BJ, Hamaguchi M, Hanafusa H . 1988 Nature 332: 272–275
Mayer BJ, Hanafusa H . 1990 Proc. Natl. Acad. Sci. USA 87: 2638–2642
Mayer BJ, Gupta R . 1998 Curr. Top Microbiol. Immunol. 228: 1–22
Meakin SO, MacDonald JI, Gryz EA, Kubu CJ, Verdi JM . 1999 J. Biol. Chem. 274: 9861–9870
Miyakawa Y, Rojnuckerian P, Habib T, Kaushansky K . 2001 J. Biol. Chem. 276: 2494–2502
Moarefi I, LaFevre-Bernt M, Sicheri F, Huse M, Lee CH, Kuriyan J, Miller WT . 1997 Nature 385: 650–653
Mongiovi AM, Romano PR, Panni S, Mendoza M, Wong WT, Musacchio A, Cesareni G, Di Fiore PP . 1999 EMBO J. 18: 5300–5309
Murakami H, Iwashita T, Asai N, Iwata Y, Narumiya S, Takahashi M . 1999 Oncogene 18: 1975–1982
Musacchio A, Wilmanns M, Saraste M . 1994 Prog. Biophys. Mol. Biol. 61: 283–297
Nagata Y, Kiefer F, Watanabe T, Todokoro K . 1999 Blood 93: 3347–3354
Nakamura K, Yano H, Uchida H, Hashimoto S, Schaefer E, Sabe H . 2000 J. Biol. Chem. 275: 27155–27164
Nakashima N, Rose DW, Xiao S, Egawa K, Martin SS, Haruta T, Saltiel AR, Olefsky JM . 1999 J. Biol. Chem. 274: 3001–3008
Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA . 1998 Science 282: 2088–2092
Nguyen JT, Porter M, Amoui M, Miller WT, Zuckermann RN, Lim WA . 2000 Chem. Biol. 7: 463–473
Nichols GL, Raines MA, Vera JC, Lacomis L, Tempst P, Golde DW . 1994 Blood 84: 2912–2918
Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T, Atsumi T, Takahashi-Tezuka M, Ishihara K, Hibi M, Hirano T . 1999 Blood 93: 1809–1816
Nishihara H, Kobayashi S, Hashimoto Y, Ohba F, Mochizuki N, Kurata T, Nagashima K, Matsuda M . 1999 Biochim. Biophys. Acta 1452: 179–187
Nojima Y, Morino N, Mimura T, Hamasaki K, Furuya H, Sakai R, Sato T, Tachibana K, Morimoto C, Yazaki Y, Hirai H . 1995 J. Biol. Chem. 270: 15398–15402
Nolan KM, Barrett K, Lu Y, Hu KQ, Vincent S, Settleman J . 1998 Genes Dev. 12: 3337–3342
Norian LA, Koretzky GA . 2000 Semin. Immunol. 12: 43–54
Nosaka Y, Arai A, Miyasaka N, Miura O . 1999 J. Biol. Chem. 274: 30154–30162
O'Neill GM, Fashena SJ, Golemis EA . 2000 Trends Cell. Biol. 10: 111–119
Oda T, Heaney C, Hagopian JR, Okuda K, Griffin JD, Druker BJ . 1994 J. Biol. Chem. 269: 22925–22928
Oda A, Sawada K, Druker BJ, Ozaki K, Takano H, Koizumi K, Fukada Y, Handa M, Koike T, Ikeda Y . 1998 Blood 92: 443–451
Oda A, Wakao H, Fujihara M, Ozaki K, Komatsu N, Tanaka S, Ikeda H, Miyajima A, Ikebuchi K . 2000 Biochem. Biophys. Res. Commun. 278: 299–305
Oehrl W . 1997 Diploma thesis University Würzburg, Germany
Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM . 1998 Oncogene 17: 1893–1901
Ogawa S, Toyoshima H, Kozutsumi H, Hagiwara K, Sakai R, Tanaka T, Hirano N, Mano H, Yazaki Y, Hirai H . 1994 Oncogene 9: 1669–1678
Ohba Y, Mochizuki N, Yamashita S, Chan AM, Schrader JW, Hattori S, Nagashima K, Matsuda M . 2000 J. Biol. Chem. 275: 20020–20026
Ohtsuka T, Shimizu K, Yamamori B, Kuroda S, Takai Y . 1996 J. Biol. Chem. 271: 1258–1261
Ojaniemi M, Vuori K . 1997 J. Biol. Chem. 272: 25993–25998
Okada S, Pessin JE . 1997 J. Biol. Chem. 272: 28179–28182
Okada S, Matsuda M, Anafi M, Pawson T, Pessin JE . 1998 EMBO J. 17: 2554–2565
Okuda K, Weisberg E, Gilliland DG, Griffin JD . 2001 Blood 97: 2440–2448
Ota J, Kimura F, Sato K, Wakimoto N, Nakamura Y, Nagata N, Suzu S, Yamada M, Shimamura S, Motoyoshi K . 1998 Biochem. Biophys. Res. Commun. 252: 779–786
Ozaki K, Oda A, Wakao H, Rhodes J, Druker BJ, Ishida A, Wakui M, Okamoto S, Morita K, Handa M, Komatsu N, Ohashi H, Miyajima A, Ikeda Y . 1998 Blood 92: 4652–4662
Park RK, Izadi KD, Deo YM, Durden DL . 1999 Blood 94: 2112–2120
Parrini MC, Mayer BJ . 1999 Chem. Biol. 6: 679–687
Pawson T . 1995 Nature 373: 573–580
Pawson T, Scott JD . 1997 Science 278: 2075–2080
Pawson T, Nash P . 2000 Genes Dev. 14: 1027–1047
Persson C, Carballeira N, Wolf-Watz H, Fallman M . 1997 EMBO J. 16: 2307–2318
Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White II GC . 1996 J. Biol. Chem. 271: 29903–29908
Petit V, Boyer B, Lentz D, Turner CE, Thiery JP, Valles AM . 2000 J. Cell. Biol. 148: 957–970
Petruzzelli L, Takami M, Herrera R . 1996 J. Biol. Chem. 271: 7796–7801
Platanias LC, Fish EN . 1999 Exp. Hematol. 27: 1583–1592
Pohl E, Holmes RK, Hol WG . 1999 J. Mol. Biol. 292: 653–667
Posern G, Rapp UR, Feller SM . 2000 Oncogene 19: 6361–6368
Qu BH, Karas M, Koval A, LeRoith D . 1999 J. Biol. Chem. 274: 31179–31184
Rani CS, Wang F, Fuior E, Berger A, Wu J, Sturgill TW, Beitner-Johnson D, LeRoith D, Varticovski L, Spiegel S . 1997 J. Biol. Chem. 272: 10777–10783
Razzini G, Ingrosso A, Brancaccio A, Sciacchitano S, Esposito DL, Falasca M . 2000 Mol. Endocrinol. 14: 823–836
Rebhun JF, Castro AF, Quilliam LA . 2000 J. Biol. Chem. 275: 34901–34908
Reddien PW, Horvitz HR . 2000 Nat. Cell. Biol. 2: 131–136
Reedquist KA, Fukazawa T, Panchamoorthy G, Langdon WY, Shoelson SE, Druker BJ, Band H . 1996 J. Biol. Chem. 271: 8435–8442
Reichman CT, Mayer BJ, Keshav S, Hanafusa H . 1992 Cell. Growth Differ. 3: 451–460
Ren R, Mayer BJ, Cicchetti P, Baltimore D . 1993 Science 259: 1157–1161
Ren R, Ye ZS, Baltimore D . 1994 Genes Dev. 8: 783–795
Ribon V, Saltiel AR . 1996 J. Biol. Chem. 271: 7375–7380
Riordan SM, Lidder S, Williams R, Skouteris GG . 2000 Biochem. J. 350: 925–932
Rohrschneider LR, Fuller JF, Wolf I, Liu Y, Lucas DM . 2000 Genes Dev. 14: 505–520
Rosen MK, Yamazaki T, Gish GD, Kay CM, Pawson T, Kay LE . 1995 Nature 374: 477–479
Rotin D, Staub O, Haguenauer-Tsapis R . 2000 J. Membr. Biol. 176: 1–17
Rozengurt E . 1998 J. Cell. Physiol. 177: 507–517
Sachs M, Brohmann H, Zechner D, Muller T, Hulsken J, Walther I, Schaeper U, Birchmeier C, Birchmeier W . 2000 J. Cell. Biol. 150: 1375–1384
Sadowski I, Stone JC, Pawson T . 1986 Mol. Cell. Biol. 6: 4396–4408
Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, Mano H, Yazaki Y, Hirai H . 1994a EMBO J. 13: 3748–3756
Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, Nishida J, Yazaki Y, Hirai H . 1994b J. Biol. Chem. 269: 32740–32746
Sakai R, Nakamoto T, Ozawa K, Aizawa S, Hirai H . 1997 Oncogene 14: 1419–1426
Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM . 2000 J. Biol. Chem. 275: 10772–10778
Sakkab D, Kardinal C, Lewitzky M, Walburg M, Knudsen B, Feller SM . 2001 Signal Transduct. 1: S25–S36
Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB, Groffen J, Griffin JD . 1995 J. Biol. Chem. 270: 29145–29150
Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD . 1996 J. Biol. Chem. 271: 25198–25203
Saltiel AR . 2001 Cell 104: 517–529
Sattler M, Salgia R, Okuda K, Uemura N, Durstin MA, Pisick E, Xu G, Li JL, Prasad KV, Griffin JD . 1996 Oncogene 12: 839–846
Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD . 1997 J. Biol. Chem. 272: 10248–10253
Sattler M, Salgia R . 1998 Leukemia 12: 637–644
Sattler M, Verma S, Pride YB, Salgia R, Rohrschneider LR, Griffen JD . 2001 J. Biol. Chem. 276: 2451–2458
Savill J, Fadok V . 2000 Nature 407: 784–788
Sawasdikosol S, Ravichandran KS, Lee KK, Chang JH, Burakoff SJ . 1995 J. Biol. Chem. 270: 2893–2896
Sawasdikosol S, Pratt JC, Meng W, Eck MJ, Burakoff SJ . 2000 Biochim. Biophys. Acta 1471: M1–M12
Sawka-Verhelle D, Tartare-Deckert S, White MF, Van Obberghen E . 1996 J. Biol. Chem. 271: 5980–5983
Sawyers CL . 1999 N. Engl. J. Med. 340: 1330–1340
Schaller MD, Parsons JT . 1995 Mol. Cell. Biol. 15: 2635–2645
Schaller MD . 2001 Oncogene 20: 6459–6472
Schillace RV, Scott JD . 1999 J. Clin. Invest. 103: 761–765
Schindler T, Bommann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J . 2000 Science 289: 1938–1942
Schlaepfer DD, Hauck CR, Sieg DJ . 1999 Prog. Biophys. Mol. Biol. 71: 435–478
Schlessinger J . 2000 Cell 103: 211–225
Schmitt JM, Stork PJ . 2000 J. Biol. Chem. 275: 25342–25350
Schmitz AA, Govek EE, Bottner B, Van Aelst L . 2000 Exp. Cell. Res. 261: 1–12
Schraw W, Richmond A . 1995 Biochemistry 34: 13760–13767
Schultz J, Copley RR, Doerks T, Ponting CP, Bork P . 2000 Nucleic. Acids Res. 28: 231–234
Schulze H, Ballmaier M, Welte K, Germeshausen M . 2000 Exp. Hematol. 28: 294–304
Sells MA, Chernoff J . 1997 Trends Cell. Biol. 7: 162–167
Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, Hobson K, Gatei M, Zhang N, Watters D, Egerton M, Shiloh Y, Kharbanda S, Kufe D, Lavin MF . 1997 Nature 387: 520–523
Shaul Y . 2000 Cell. Death Differ. 7: 10–16
Shi CS, Kehrl JH . 1997 J. Biol. Chem. 272: 32102–32107
Shi CS, Tuscano J, Kehrl JH . 2000 Blood 95: 776–782
Shishido T, Akagi T, Chalmers A, Maeda M, Terada T, Georgescu M-M, Hanafusa H . 2001 Genes Cells 6: 431–440
Shivakrupa Singh R, Swarup G . 1999 DNA Cell. Biol. 18: 701–708
Sicheri F, Moarefi I, Kuriyan J . 1997 Nature 385: 602–609
Simons K, Toomre D . 2000 Nature Rev. Molec. Cell. Biol. 1: 31–39
Smit L, van der Horst G, Borst J . 1996a J. Biol. Chem. 271: 8564–8569
Smit L, van der Horst G, Borst J . 1996b Oncogene 13: 381–389
Smit L, Borst J . 1997 Crit. Rev. Oncog. 8: 359–379
Smith JJ, Evans EK, Murakami M, Moyer MB, Moseley MA, Woude GV, Kornbluth S . 2000 J. Cell. Biol. 151: 1391–1400
Smithgall TE, Briggs SD, Schreiner S, Lerner EC, Cheng H, Wilson MB . 2000 Oncogene 19: 2612–2618
Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF . 1999 Cell 98: 181–191
Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, Neel BG, Birge RB, Fajardo JE, Chou MM, Hanafusa H, Schaffhausen B, Cantley LC . 1993 Cell 72: 767–778
Sorokin A, Reed E . 1998 Biochem. J. 334: 595
Sorokin A, Reed E, Nnkemere N, Dulin NO, Schlessinger J . 1998 Oncogene 16: 2425–2434
Sparks AB, Rider JE, Hoffman NG, Fowlkes DM, Quillam LA, Kay BK . 1996 Proc. Natl. Acad. Sci. USA 93: 1540–1544
Stoll R, Renner C, Zweckstetter M, Bruggert M, Ambrosius D, Palme S, Engh RA, Golob M, Breibach I, Buettner R, Voelter W, Holak TA, Bosserhoff AK . 2001 EMBO J. 20: 340–349
Stupack DG, Cho SY, Klemke RL . 2000 Immunol. Res. 21: 83–88
Takahashi T, Kawahara Y, Taniguchi T, Yokoyama M . 1998 Am. J. Physiol. 274: H1059–H1065
Tanaka S, Hattori S, Kurata T, Nagashima K, Fukui Y, Nakamura S, Matsuda M . 1993 Mol. Cell. Biol. 13: 4409–4415
Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K, et al. 1994 Proc. Natl. Acad. Sci. USA 91: 3443–3447
Tanaka S, Ouchi T, Hanafusa H . 1997 Proc. Natl. Acad. Sci. USA 94: 2356–2361
Tanaka S, Hanafusa H . 1998 J. Biol. Chem. 273: 1281–1284
ten Hoeve J, Morris C, Heisterkamp N, Groffen J . 1993 Oncogene 8: 2469–2474
ten Hoeve J, Arlinghaus RB, Guo JQ, Heisterkamp N, Groffen J . 1994a Blood 84: 1731–1736
ten Hoeve J, Kaartinen V, Fioretos T, Haataja L, Voncken JW, Heisterkamp N, Groffen J . 1994b Cancer Res. 54: 2563–2567
Thomas SM, Hagel M, Turner CE . 1999 J. Cell. Sci. 112: 181–190
Torres M, Bogenmann E . 1996 Oncogene 12: 77–86
Tosello-Trampont AC, Brugnera E, Ravichandran KS . 2001 J. Biol. Chem. 276: 13797–13802
Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD . 2000 Biochem. J. 350: Pt 1 19–29
Tsuchie H, Chang CH, Yoshida M, Vogt PK . 1989 Oncogene 4: 1281–1284
Tsuruzoe K, Emkey R, Kriauciunas KM, Ueki K, Kahn CR . 2001 Mol. Cell. Biol. 21: 26–38
Tsygankov AY . 2001 Oncogene 20: 6382–6402
Tu Y, Kucik DF, Wu C . 2001 FEBS Lett. 491: 193–199
Tuchscherer G, Grell D, Tatsu Y, Durieux P, Fernandez-Carneado J, Hengst B, Kardinal C, Feller SM . 2001 Angew. Chemie in press
Tung RM, Blenis J . 1997 Oncogene 14: 653–659
Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S, Leventhal PS . 1999 J. Cell. Biol. 145: 851–863
Turner CE . 2000 Nat. Cell. Biol. 2: E231–E236
Uemura N, Griffin JD . 1999 J. Biol. Chem. 274: 37525–37532
van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC . 1998 EMBO J. 17: 2799–2808
van den Berghe N, Cool RH, Hom G, Wittinghofer A . 1997 Oncogene 15: 845–850
van der Flier S, Brinkman A, Look MP, Kok EM, Meijer-van Gelder ME, Klijn JG, Dorssers LC, Foekens JA . 2000a J. Natl. Cancer Inst. 92: 120–127
van der Flier S, Chan CM, Brinkman A, Smid M, Johnston SR, Dorssers LC, Dowsett M . 2000b Int. J. Cancer 89: 465–468
van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Lowenberg B, von Lindern M . 2000 Blood 96: 3406–3413
Voss J, Posern G, Hannemann JR, Wiedemann LM, Turhan AG, Poirel H, Bernard OA, Adermann K, Kardinal C, Feller SM . 2000 Oncogene 19: 1684–1690
Voss J, Heisterkamp N, Groffen J, Feller SM . 2001 Signal Transduct 1: 1–26
Vossler MR, Yao H, York RD, Pan MG, Rim CS, Stork PJ . 1997 Cell 89: 73–82
Vuori K, Hirai H, Aizawa S, Ruoslahti E . 1996 Mol. Cell. Biol. 16: 2606–2613
Wang JY . 2000 Oncogene 19: 5643–5650
Weed SA, Parsons JJ . 2001 Oncogene 20: 6418–6434
Weaver AM, Karginov AV, Kinley AW, Weed SA, Li Y, Parsons JT, Cooper JA . 2001 Curr. Biol. 11: 370–374
Weidow CL, Black DS, Bliska JB, Bouton AH . 2000 Cell. Microbiol. 2: 549–560
Whisstock JC, Lesk AM . 1999 Trends Biochem. Sci. 24: 132–133
White MF . 1998 Recent Prog. Horm. Res. 53: 119–138
Whitehead JP, Clark SF, Urso B, James DE . 2000 Curr. Opin. Cell. Biol. 12: 222–228
Wickrema A, Uddin S, Sharma A, Chen F, Alsayed Y, Ahmad S, Sawyer ST, Krystal G, Yi T, Nishada K, Hibi M, Hirano T, Platanias LC . 1999 J. Biol. Chem. 274: 24469–24474
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF . 1998 Nature 391: 900–904
Wojchowski DM, Gregory RC, Miller CP, Pandit AK, Pircher TJ . 1999 Exp. Cell. Res. 253: 143–156
Wolf G, Trub T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE . 1995 J. Biol. Chem. 270: 27407–27410
Wolthuis RM, Bauer B, van't Veer LJ, de Vries-Smits AM, Cool RH, Spaargaren M, Wittinghofer A, Burgering BM, Bos JL . 1996 Oncogene 13: 353–362
Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J . 1995 Structure 3: 215–226
Wu YC, Horvitz HR . 1998 Nature 392: 501–504
Xing L, Ge C, Zeltser R, Maskevitch G, Mayer BJ, Alexandropoulos K . 2000 Mol. Cell. Biol. 20: 7363–7377
Xu W, Harrison SC, Eck MJ . 1997 Nature 385: 595–602
Yamabhai M, Kay BK . 1997 Anal. Biochem. 247: 143–151
Yamanashi Y, Baltimore D . 1997 Cell 88: 205–211
Yamashita S, Mochizuki N, Ohba Y, Tobiume M, Okada Y, Sawa H, Nagashima K, Matsuda M . 2000 J. Biol. Chem. 275: 25488–25493
Yano H, Cong F, Birge RB, Goff SP, Chao MV . 2000a J. Neurosci. Res. 59: 356–364
Yano H, Uchida H, Iwasaki T, Mukai M, Akedo H, Nakamura K, Hashimoto S, Sabe H . 2000b Proc. Natl. Acad. Sci. USA 97: 9076–9081
Yokote K, Hellman U, Ekma S, Saito Y, Ronnstrand L, Saito Y, Heldin CH, Mori S . 1998 Oncogene 16: 1229–1239
York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, Stork PJ . 1998 Nature 392: 622–626
Yoshizumi M, Abe J, Haendeler J, Huang Q, Berk BC . 2000 J. Biol. Chem. 275: 11706–11712
Zhao C, Yu DH, Shen R, Feng GS . 1999 J. Biol. Chem. 274: 19649–19654
Zhou Z, Hartwieg E, Horvitz HR . 2001 Cell 104: 43–56
Zhu T, Goh EL, LeRoith D, Lobie PE . 1998 J. Biol. Chem. 273: 33864–33875
Zvara A, Fajardo JE, Escalante M, Cotton G, Muir T, Kirsch KH, Birge RB . 2001 Oncogene 20: 951–961
Zwartkruis FJ, Bos JL . 1999 Exp. Cell. Res. 253: 157–165
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