Abstract
The transmembrane adapter LAT (linker for activation of T cells) plays a central role in signalling by ITAM bearing receptors expressed on T cells, natural killer cells, mast cells and platelets. Receptor engagement leads to the phosphorylation of tyrosine residues present in the intracellular domain of LAT and formation of a multiprotein complex with other adapter molecules and enzymes including Grb2, Gads/SLP-76 and PLCĪ³ isoforms. These signalling events predominantly take place in glycolipid-enriched membrane domains. The constitutive presence of LAT in GEMs enables its function as the main scaffolding protein for the organization of GEM-localized signalling. The study of LAT-deficient mice and LAT-deficient cell lines further emphasizes the importance of LAT for these signalling cascades but also defines the existence of LAT-independent events downstream of the Syk-family kinase-ITAM complex.
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Acknowledgements
We thank Jonathan I Wilde and Regis Bobe for helpful discussion. Work in the authors' laboratory is supported by the Wellcome Trust and the British Heart Foundation. SP Watson is a British Heart Foundation Senior Research Fellow.
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Wonerow, P., Watson, S. The transmembrane adapter LAT plays a central role in immune receptor signalling. Oncogene 20, 6273ā6283 (2001). https://doi.org/10.1038/sj.onc.1204770
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