Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

DNA methylation, methyltransferases, and cancer

Oncogene volume 20, pages 3139–3155 (2001)Cite this article

Abstract

The field of epigenetics has recently moved to the forefront of studies relating to diverse processes such as transcriptional regulation, chromatin structure, genome integrity, and tumorigenesis. Recent work has revealed how DNA methylation and chromatin structure are linked at the molecular level and how methylation anomalies play a direct causal role in tumorigenesis and genetic disease. Much new information has also come to light regarding the cellular methylation machinery, known as the DNA methyltransferases, in terms of their roles in mammalian development and the types of proteins they are known to interact with. This information has forced a new view for the role of DNA methyltransferases. Rather than enzymes that act in isolation to copy methylation patterns after replication, the types of interactions discovered thus far indicate that DNA methyltransferases may be components of larger complexes actively involved in transcriptional control and chromatin structure modulation. These new findings will likely enhance our understanding of the myriad roles of DNA methylation in disease as well as point the way to novel therapies to prevent or repair these defects.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

Similar content being viewed by others

References

  • Aapola U, Shibuya K, Scott HS, Ollila J, Vihinen M, Heino M, Shintani A, Kawasaki K, Minoshima S, Krohn K, Antonarakis SE, Shimizu N, Kudoh J, Peterson P . 2000 Genomics 65: 293–298

  • Aasland R, Gibson TJ, Stewart AF . 1995 TIBS 20: 56–59

  • Altieri F, Maras B, Turano C . 1996 Biochem. Biophys. Res. Commun. 225: 448–454

  • Annuziato AT, Seale RL . 1983 J. Biol. Chem. 258: 12675–12684

  • Antequera F, Bird A . 1993 Proc. Natl. Acad. Sci. USA 90: 11995–11999

  • Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavanee WK, Baylin SB, Graff JR . 1999 Cancer Res. 59: 798–802

  • Barwise JL, Walker JH . 1996 FEBS Lett. 394: 213–216

  • Baylin SB, Herman JG . 2000 TIG 16: 168–174

  • Beard C, Li E, Jaenisch R . 1995 Genes. Dev. 9: 2325–2334

  • Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, Baylin SB, Herman JG . 1998 Proc. Natl. Acad. Sci. USA 95: 11891–11896

  • Berube NG, Smeenk CA, Picketts DJ . 2000 Hum. Mol. Genet. 9: 539–547

  • Bestor T, Laudano A, Mattaliano R, Ingram V . 1988 J. Mol. Biol 203: 971–983

  • Bestor TH, Ingram VM . 1983 Proc. Natl. Acad. Sci. USA 80: 5559–5563

  • Bestor TH, Tycko B . 1996 Nature Genet. 12: 363–367

  • Bird AP, Wolffe AP . 1999 Cell 99: 451–454

  • Brehm A, Kouzarides T . 1999 TIBS 24: 142–145

  • Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG . 1997 Cell 91: 845–854

  • Buchner J . 1999 TIBS 24: 136–141

  • Burdon RH, Qureshi M, Adams RLP . 1985 Biochim. Biophys. Acta 825: 70–79

  • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB . 1999 Nature Genet. 21: 103–107

  • Campanero MR, Armstrong MI, Flemington EK . 2000 Proc. Natl. Acad. Sci. USA

  • Cao X, Springer NM, Muszynski MG, Phillips RL, Kaeppler S, Jacobsen SE . 2000 Proc. Natl. Acad. Sci. USA 97: 4979–4984

  • Cardoso C, Timsit S, Villard L, Khrestchatisky M, Fontes M, Colleaux L . 1998 Hum. Mol. Genet. 7: 679–684

  • Carotti D, Funiciello S, Lavia P, Caiafa P, Strom R . 1996 Biochemistry 35: 11660–11667

  • Carpenter NJ, Fillpovich A, Blaese M, Carey TL, Berkel I . 1988 J. Pediat. 112: 757–760

  • Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R . 1998 Nature 395: 89–93

  • Cheng NC, Chan AJK, Beitsma MM, Speleman F, Westerveld A, Versteeg R . 1996 Hum. Mol. Genet. 5: 309–317

  • Chuang LS-H, Ian H-I, Koh T-W, Ng H-H, Xu G, Li BFL . 1997 Science 277: 1996–2000

  • Colot V, Rossignol J-L . 1999 BioEssays 21: 402–411

  • Corn PG, Kuerbitz SJ, vanNoesel MM, Esteller M, Compitello N, Baylin SB, Herman JG . 1999 Cancer Res. 59: 3352–3356

  • Costello JF, Fruhwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Fermisco JD, Peltomaki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Huang H-JS, Petrelli NJ, Zhang X, O'Dorisio MS, Held WA, Cavenee WK, Plass C . 2000 Nature Genet. 25: 132–138

  • Dobrovic A, Simpfendorfer D . 1997 Cancer Res. 57: 3347–3350

  • Dyson N . 1998 Genes. Dev. 12: 2245–2262

  • Eads CA, Danenberg KD, Kawakani K, Saltz LB, Dannenberg PV, Liard PW . 1999 Cancer Res. 59: 302–306

  • Eden S, Hashimshony T, Keshet I, Cedar H, Thorne AW . 1998 Nature 394: 842

  • El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trant JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B . 1993 Cell 75: 817–825

  • Endres M, Meisel A, Biniszkiewicz D, Namura S, Prass K, Ruscher K, Lipski A, Jaenisch R, Moskowitz MA, Dirnagl U . 2000 J. Neurosci. 20: 3175–3181

  • Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, Aaltonen LA, Herman JG . 2000a Oncogene 19: 164–168

  • Esteller M, Corn PG, Urena JM, Gabrielson E, Baylin SB, Herman JG . 1998 Cancer Res. 58: 4515–4518

  • Esteller M, Tortola S, Capella G, Peinado MA, Baylin SB, Herman JG . 2000b Cancer Res. 60: 129–133

  • Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN, Issa JP, Sidransky D, Baylin SB, Herman JG . 2000c Cancer Res. 60: 2368–2371

  • Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M . 1988 Cancer Res. 48: 1159–1161

  • Flori AR, Lower R, Schmitz-Drager BJ, Schulz WA . 1999 Brit. J. Canc. 80: 1312–1321

  • Franceschini P, Martino S, Ciocchini M, Ciuti E, Vardeu MP, Guala A, Signorile F, Camerano P, Franceschini D, Tovo PA . 1995 Eur. J. Pediatr. 154: 840–846

  • Fuks F, Bergers WA, Brehm A, Hughes-Davies L, Kouzarides T . 2000 Nature Genet. 24: 88–91

  • Gaillard P-HL, Martini EM-D, Kaufman PD, Stillman B, Moustacchi E, Almouzni G . 1996 Cell 86: 557–896

  • Geiman TM, Muegge K . 2000 Proc. Natl. Acad. Sci. USA 97: 4772–4777

  • Gibbons RJ, McDowell TL, Raman S, O'Rourke DM, Garrick D, Ayyub H, Higgs DR . 2000 Nature Genet. 24: 368–371

  • Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP . 1985 Science 228: 187–190

  • Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T-D, Beart RW, VanTornout JM, Jones PA . 1995 Cancer Res. 55: 4531–4535

  • Goto K, Numatas M, Momuram J-I, Ono Y, Bestor T, Kondo H . 1993 Differentiation 56: 39–44

  • Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB . 1995 Cancer Res. 55: 5195–5199

  • Grassi M, Girault JM, Wang WP, Thiery JP, Jouanneau J . 1999 Gene 233: 59–66

  • Hanahan D, Weinberg RA . 2000 Cell 100: 57–70

  • Hansen RS, Stoger R, Wijmenga C, Stanek AM, Canfield TK, Luo P, Matarazzo MR, D-Esposito M, Feil R, Gimelli G, Weemaes CMR, Laird CD, Gartler SM . 2000 Hum. Mol. Genet. 9: 2575–2587

  • Hansen RS, Wijmenga C, Luo P, Stanek AM, Canfield TK, Weemaes CMR, Gartler SM . 1999 Proc. Natl. Acad. Sci. USA 96: 14412–14417

  • Heim S, Mitelman F . 1995 Wiley-Liss: New York pp. 369–388

  • Hendrich B, Bird A . 1998 Mol. Cell. Biol. 10: 6538–6547

  • Herman JG, Jen J, Merlo A, Baylin SB . 1996 Cancer Res. 54: 722–727

  • Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan D-SR, Gnarra JR, Linehan WM, Baylin SB . 1994 Proc. Natl. Acad. Sci. USA 91: 9700–9704

  • Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa J-PJ, Markowitz S, Willson JKV, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA, Baylin SB . 1998 Proc. Natl. Acad. Sci. USA 98: 6870–6875

  • Hiltunen MO, Alhonen L, Koistinaho J, Myohanen S, Paakkonen M, Marin S, Kosma VM, Janne J . 1997 Int. J. Cancer 70: 644–648

  • Hittelman AB, Burakov D, Iniguez-Lluhi JA, Freeman LP, Garabedian MJ . 1999 EMBO J. 18: 5380–5388

  • Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA . 1999 Genes. Dev. 13: 817–826

  • Hough RF, Bass BL . 1997 RNA 3: 356–370

  • Hsieh C-L . 1999 Mol. Cell. Biol. 19: 8211–8218

  • Hsieh C-L, Lieber MR . 1992 EMBO J. 11: 3115–325

  • Issa J-P, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB . 1994 Nature Genet. 7: 536–540

  • Issa J-P, Vertino PM, Wu J, Sazawal S, Celano P, Nelkin BD, Hamilton SR, Baylin SB . 1993 J. Natl. Cancer Inst. 85: 1235–1240

  • Jeanpierre M, Turleau C, Aurias A, Prieur M, Ledeist F, Fischer A, Viegas-Pequignot E . 1993 Hum. Mol. Genet. 2: 731–735

  • Jeddeloh JA, Stokes TL, Richards EJ . 1999 Nature Genet. 22: 94–97

  • Ji W, Hernandez R, Zhang XY, Qu GZ, Frady A, Varela M, Ehrlich M . 1997 Mutat. Res. 379: 33–41

  • Johnson JL, Beito TG, Krco CJ, Toft DO . 1994 Mol. Cell. Biol. 14: 1956–1963

  • Jones PA . 1996 Cancer Res. 56: 2463–2467

  • Jones PA, Laird PW . 1999 Nature Genet. 21: 163–166

  • Jones PL, Veenstra GJC, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, Wolffe AP . 1998 Nature Genet. 19: 187–191

  • Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM, Kolodner R . 1997 Cancer Res. 57: 808–811

  • Kastan MB, Gowans BJ, Lieberman MW . 1982 Cell 30: 509–615

  • Katzenellenbogen RA, Baylin SB, Herman JG . 1999 Blood 93: 4347–4353

  • Kaufman PD, Kobayashi R, Kessler N, Stillman B . 1995 Cell 81: 1105–1114

  • Kawano S, Miller CW, Gombart AF, Bartram CR, Matsuo Y, Asou H, Sakashita A, Said J, Tatsumi E, Koeffler HP . 1999 Blood 94: 1113–1120

  • Kelman Z . 1997 Oncogene 14: 629–640

  • Klimasauskas S, Kumar S, Roberts RJ, Cheng X . 1994 Cell 76: 357–369

  • Kochanek S, Renz D, Doerfler W . 1995 FEBS Lett. 360: 115–120

  • Kondo T, Bobek MP, Kuick R, Lamb B, Zhu X, Narayan A, Bourc'his D, Viegas-Pequignot E, Ehrlich M, Hanash SM . 2000 Hum. Mol. Genet. 9: 597–604

  • Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG . 1994 Nucleic Acids Res. 22: 1–10

  • Lee PJ, Washer LL, Law DJ, Boland CR, Horon IL, Feinberg AP . 1996 Proc. Natl. Acad. Sci. USA 93: 10366–10370

  • Lee W-H, Morton RA, Epstein JI, Brooks JD, Campbell PA, Bova GS, Hsieh W-s, Isaacs WB, Nelson WG . 1994 Proc. Natl. Acad. Sci. USA 91: 11733–11737

  • Lei H, Oh SP, Okano M, Juttermann R, Goss KA, Jaenisch R, Li E . 1996 Development 122: 3195–3205

  • Leonhardt H, Page AW, Weier H, Bestor TH . 1992 Cell 71: 865–873

  • Lewis JD, Meehan RR, Henzel WJ, Maurer-Fogy I, Jeppesen P, Klein F, Bird A . 1992 Cell 69: 905–914

  • Li E, Beard C, Jaenisch R . 1993 Nature 366: 362–365

  • Li E, Bestor TH, Jaenisch R . 1992 Cell 69: 915–926

  • Li L, Cohen SN . 1996 Cell 85: 319–329

  • Liu Y, Oakeley EJ, Sun L, Jost J-P . 1998 Nucleic Acids Res. 26: 1038–1045

  • Lyko F, Ramsahoye BH, Jaenisch R . 2000 Nature 408: 538–540

  • Lyko F, Ramsahoye BH, Kashevsky H, Tudor M, Mastrangelo M-A, Orr-Weaver TL, Jaenisch R . 1999 Nature Genet. 23: 363–366

  • Maloisel L, Rossignol J-L . 1998 Genes. Dev. 12: 1381–1389

  • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D . 1995 Nature Med. 1: 686–692

  • Mertens F, Johansson B, Hoglund M, Mitelman F . 1997 Cancer Res. 57: 2765–2780

  • Miniou P, Jeanpierre M, Blanquet V, Sibella V, Bonneau D, Herbelin C, Fischer A, Niveleau A, Viegas-Pequignot E . 1994 Hum. Mol. Genet. 3: 2093–2102

  • Miyata Y, Yahara I . 1991 J. Biol. Chem. 266: 8779–8783

  • Moran E . 1993 Curr. Opin. Genet. Dev. 3: 63–70

  • Myohanen SK, Baylin SB, Herman JG . 1998 Cancer Res. 58: 591–593

  • Nan X, Campoy FJ, Bird A . 1997 Cell 88: 471–481

  • Nan X, Ng H-H, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A . 1998 Nature 393: 386–389

  • Narayan A, Ji W, Zhang X-Y, Marrogi A, Graff JR, Baylin SB, Ehrlich M . 1998 Int. J. Cancer 77: 833–838

  • Narayan A, Tuck-Muller C, Weissbecker K, Smeets D, Ehrlich M . 2000 Mutat. Res. 456: 1–15

  • Ng H-H, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A . 1999 Nature Genet. 23: 58–61

  • Nichols AF, Sancar A . 1992 Nucleic Acids Res. 20: 2441–2446

  • Nuovo GJ, Plaia TW, Belinsky SA, Baylin SB, Herman JG . 1999 Proc. Natl. Acad. Sci. USA 96: 12754–12759

  • Ohsawa K, Imai Y, Ito D, Kohsaka S . 1996 J. Neurochem. 67: 89–97

  • Okano M, Bell DW, Haber DA, Li W . 1999 Cell 99: 247–257

  • Okano M, Xie S, Li E . 1998a Nature Genet. 19: 219–220

  • Okano M, Xie S, Li E . 1998b Nucleic Acids Res. 26: 2536–2540

  • Picketts DJ, Higgs DR, Bachoo S, Blake DJ, Quarrell OWJ, Gibbons RJ . 1996 Hum. Mol. Genet. 5: 1899–1907

  • Pradhan S, Bacolla A, Wells RD, Roberts RJ . 1999 J. Biol. Chem. 274: 33002–33010

  • Pradhan S, Talbot D, Sha M, Benner J, Hornstra L, Li E, Yaenisch R, Roberts RJ . 1997 Nucleic Acids Res. 25: 4666–4673

  • Puget N, Torchard D, Serova-Sinilnikova OM, Lynch HT, Feunteun J, Lenoir GM, Mazoyer S . 1997 Cancer Res. 57: 828–831

  • Qian XC, Brent TP . 1997 Cancer Res. 57: 3672–3677

  • Qu G-z, Dubeau L, Narayan A, Yu MC, Ehrlich M . 1999 Mutat. Res. 423: 91–101

  • Ramsahoye BH, Biniszkiewicz D, Lyko F, Clark V, Bird AP, Jaenisch R . 2000 Proc. Natl. Acad. Sci. USA 97: 5237–5242

  • Raynal P, Kuijpers G, Rojas E, Pollard HB . 1996 FEBS Lett. 392: 263–268

  • Rhee I, Jair K-W, Yen R-WC, Lengauer C, Herman JG, Kinzler KW, Vogelstein B, Baylin SB, Schuebel KE . 2000 Nature 404: 1003–1007

  • Rice JC, Futscher BW . 2000 Nucleic Acids Res. 28: 3233–3239

  • Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP . 2000a Nature Genet. 25: 338–342

  • Robertson KD, Jones PA . 1998 Mol. Cell. Biol. 18: 6457–6473

  • Robertson KD, Keyomarsi K, Gonzales FA, Velicescu M, Jones PA . 2000b Nucleic Acids Res. 28: 2108–2113

  • Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA, Jones PA . 1999 Nucleic Acids Res. 27: 2291–2298

  • Robertson KD, Wolffe AP . 2000 Nature Rev. Genet. 1: 11–19

  • Rouleau J, Tanigawa G, Szyf M . 1992 J. Biol. Chem. 267: 7368–7377

  • Rountree MR, Bachman KE, Baylin SB . 2000 Nature Genet. 25: 269–277

  • Rouyer F, Simmler MC, Page D, Weissenbach J . 1987 Cell 51: 417–425

  • Sakai T, Toguchida J, Ohtani N, Yandell DW, Papaport JM, Dryja TP . 1991 Am. J. Hum. Genet. 48: 880–888

  • Sawyer JR, Swanson CM, Wheeler G, Cunniff C . 1995 Am. J. Med. Genet. 56: 203–209

  • Shibahara K-i, Stillman B . 1999 Cell 96: 575–585

  • Small K, Iber J, Warren ST . 1997 Nature Genet. 16: 96–99

  • Smeets DFCM, Moog U, Weemaes CMR, Vaes-Peeters G, Merkx GFM, Niehof JP, Hamers G . 1994 Hum. Genet. 94: 240–246

  • Stewart AF, Gibson T . 1996 TIBS 21: 87–88

  • Stirzaker C, Millar DS, Paul CL, Warnecke PM, Harrison J, Vincent PC, Frommer M, Clark SJ . 1997 Cancer Res. 57: 2229–2237

  • Szyf M, Bozovic V, Tanigawa G . 1991 J. Biol. Chem. 266: 10027–10030

  • Tagarro I, Fernandez-Peralta AM, Gonzales-Aguilera JJ . 1994 Hum. Genet. 93: 383–388

  • Tate PH, Bird AP . 1993 Curr. Opin. Genet. Dev. 3: 226–231

  • Tatematsu K-i, Yamazaki T, Ishikawa F . 2000 Genes to Cells 5: 677–688

  • Tucker KL, Talbot D, Lee MA, Leonhardt H, Jaenisch R . 1996 Proc. Natl. Acad. Sci. USA 93: 12920–12925

  • Tuck-Muller CM, Narayan A, Tsien F, Smeets DFCM, Sawyer J, Fiala ES, Sohn OS, Ehrlich M . 2000 Cytogenet. Cell Genet. 89: 121–128

  • Umar A, Buermeyer AB, Simon JA, Thomas DC, Clark AB, Liskay RM, Kunkel TA . 1996 Cell 87: 65–73

  • Vertino PM, Yen R-WC, Gao J, Baylin SB . 1996 Mol. Cell. Biol. 16: 4555–4565

  • Vogelstein B, Lane D, Levine AJ . 2000 Nature 408: 307–310

  • Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP . 1999 Nature Genet. 23: 62–66

  • Waga S, Hannon GJ, Beach D, Stillman B . 1994 Nature 369: 574–578

  • Wakefield RID, Smith BO, Nan X, Free A, Soteriou A, Uhrin D, Bird AP, Barlow PN . 1999 J. Mol. Biol 291: 1055–1065

  • Walsh CP, Chaillet JR, Bestor TH . 1998 Nature Genet. 20: 116–117

  • Wijmenga C, van den Heuvel LPWJ, Strengman E, Luyten JAFM, van der Burgt IJAM, de Groot R, Smeets DFCM, Draaisma JMT, van Dongen JJ, De Abreu RA, Pearson PL, Sandkuijl LA, Weemaes CMR . 1998 Am. J. Hum. Genet. 63: 803–809

  • Wong DJ, Foster SA, Galloway DA, Reid BJ . 1999 Mol. Cell. Biol. 19: 5642–5651

  • Wu J, Issa JP, Herman J, Bassett DE, Nelkin BD, Baylin SB . 1993 Proc. Natl. Acad. Sci. USA 90: 8891–8895

  • Xie S, Wang Z, Okano M, Nogami M, Li Y, He W-W, Okumura K, Li E . 1999 Gene 236: 87–95

  • Xu G-L, Bestor TH, Bourc'his D, Hsieh C-L, Tommerup N, Bugge M, Hulten M, Qu, Russo JJ, Viegas-Pequignot E . 1999 Nature 402: 187–191

  • Yoder JA, Bestor TH . 1998 Hum. Mol. Genet. 7: 279–284

  • Yoder JA, Walsh CP, Bestor TH . 1997 TIG 13: 335–340

  • Yoder JA, Yen R-WC, Vertino PM, Bestor TH, Baylin SB . 1996 J. Biol. Chem. 271: 31092–31097

  • Yoshiura K, Kanai Y, Shimoyama Y, Sugimura T, Hirohashi S . 1995 Proc. Natl. Acad. Sci. USA 92: 7416–7419

  • Zhang X, Verdine GL . 1996 FEBS Lett. 392: 179–183

Download references

Author information

Authors and Affiliations

  1. Epigenetic Gene Regulation and Cancer Section, National Cancer Institute, NIH, Bldg. 41, 41 Library Dr., Bethesda, 20892, Maryland, MD, USA

    Keith D Robertson

Authors
  1. Keith D Robertson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Robertson, K. DNA methylation, methyltransferases, and cancer. Oncogene 20, 3139–3155 (2001). https://doi.org/10.1038/sj.onc.1204341

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1204341

Keywords

This article is cited by

Search

Advanced search

Quick links