Figure 1 | Oncogene

Figure 1

From: Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

Figure 1

Potential influence of stromal cell secreted (plasminogen activator) and cell surface proteinases and proteinase inhibitors (TIMPs, α1 proteinase inhibitor) on cancer progression with an emphasis on matrix metalloproteinases (MMPs). Effect of MMPs on integrins, cadherin, CD44, perlecan, cytokines (IL1-β), plasminogen, fibroblast growth factor (FGF), epithelial growth factor (EGF), insulin-like growth factor (IGF), binding proteins for growth factors (IGF-BP, FGF-BP), growth factor receptors (FGF-R), extracellular matrix proteins (collagen, laminin, vitronectin, fibronectin, enactin, decorin), and apoptosis factors (FAS ligand)