Figure 7 | Oncogene

Figure 7

From: Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

Figure 7

Immunohistochemistry for HIF-1α and HIF-2α in hemangioblastoma (left column) and renal cell carcinoma (right column) with HIF-1α antibody (Novus) and polyclonal HIF-2α antibody. HIF-1α and HIF-2α in tumor cell nuclei of hemangioblastoma (stromal cell component) and RCC, note low cytoplasmic expression of HIF-2α. Moderate HIF-2α expression was also observed in endothelial cells (see 1000× magnification of hemangioblastoma); upper rows: 400×, lower rows: 1000× magnification; insets show negative controls without first antibody

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