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Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL

Oncogene volume 19, pages 4802–4806 (2000)Cite this article

Abstract

The TEL/ETV6 gene is located at 12p13 and is frequently involved in chromosomal translocations in human malignancies usually resulting in the expression of fusion proteins between the amino terminal part of TEL, and either unrelated transcription factors or protein tyrosine kinases. We report here a novel gene named TELB which is located on human chromosomal band 6p21 and encodes a protein highly related to TEL. TELB is widely expressed in different tissues and, similarly to TEL encodes a sequence-specific transcriptional repressor.

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Acknowledgements

This work was supported by grants from the Association de Recherche sur le Cancer (ARC) and the Ligue Nationale Contre le Cancer (LNCC).

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Authors and Affiliations

  1. U434 INSERM-CEPH, 27 rue Juliette Dodu, 75010, Paris, France

    Hèléne Poirel, Virginie Lacronique, Véronique Della Valle, Martine Mauchauffé, Roland Berger & Olivier A Bernard

  2. CNRS UMR 146, Institut Curie, Bat 110, Centre Universitaire 91405 Orsay Cedex, France

    Rodolphe G Lopez & Jacques Ghysdael

Authors
  1. Hèléne Poirel
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  2. Rodolphe G Lopez
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  3. Virginie Lacronique
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  4. Véronique Della Valle
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  5. Martine Mauchauffé
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  6. Roland Berger
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  7. Jacques Ghysdael
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  8. Olivier A Bernard
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Poirel, H., Lopez, R., Lacronique, V. et al. Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL. Oncogene 19, 4802–4806 (2000). https://doi.org/10.1038/sj.onc.1203830

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  • DOI: https://doi.org/10.1038/sj.onc.1203830

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