Figure 7 | Oncogene

Figure 7

From: Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment

Figure 7

Intracellular ScFv anti-ATF-1 induces apoptosis in vivo. In situ demonstration of DNA fragmentation in tumor cells expressing ScFv anti-ATF-1 using the TUNEL methodology. The positive reaction for cells undergoing apoptosis was indicated by a strong reddish brown precipitate. No apoptosis was observed in MeWo parental cells, very few apoptotic cells were observed in tumors produced by neo-control cells, while a massive apoptosis was observed in tumors expressing ScFv anti-ATF-1. (B) ×4 magnification to show a larger area of the tumors

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