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The role of STATs in myeloid differentiation and leukemia

Oncogene volume 19, pages 2511–2522 (2000)Cite this article

Abstract

Myeloid differentiation is a highly regulated process governed by various cytokines, such as EPO, TPO, G-CSF, IL-3, IL-5 and GM-CSF. These cytokines act in part through activation of the STAT transcription factor family. In particular, various isoforms of STAT3 and STAT5 are activated during myeloid differentiation in a cell-type and maturation-state dependent fashion. In vitro studies have shown that STAT proteins are essential for cytokine-regulated processes such as cellular proliferation, differentiation as well as survival. Similarly, various STAT knock-outs have highlighted the role of STATs in myeloid differentiation in vivo. STATs also appear to play an important role in various myeloid malignancies, which are characterized by arrested maturation and cytokine-independent proliferation of myeloid progenitors. Constitutive activation of STAT3 and/or STAT5 resulting in enhanced transcription of anti-apoptotic- cell-cycle progression genes is likely to contribute to the pathogenesis of various myeloid leukemia's.

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Acknowledgements

P Coffer is supported by a research grant from GlaxoWellcome. RP de Groot is supported by a fellowship from the Royal Netherlands Academy of Arts and Sciences.

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  1. Department of Pulmonary Diseases, Room G03 550, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584CX, The Netherlands

    Paul J Coffer, Leo Koenderman & Rolf P de Groot

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Coffer, P., Koenderman, L. & de Groot, R. The role of STATs in myeloid differentiation and leukemia. Oncogene 19, 2511–2522 (2000). https://doi.org/10.1038/sj.onc.1203479

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