Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Report
  • Published:

The putative tumour suppressor Fus-2 is an N-acetyltransferase

Oncogene volume 19, pages 161–163 (2000)Cite this article

Abstract

Acetyltransferases are essential enzymes for a wide variety of cellular processes and mutations in acetyltransferase genes have been associated with the development of certain cancers. For this reason, we conducted a computerized sequence homology search for novel acetyltransferases. Here, we show that the putative tumour suppressor protein Fus-2 has homology to the catalytic domain of acetyltransferases. We demonstrate that Fus-2 can acetylate the N-terminus of proteins using a ping-pong mechanism and that it has a specificity for substrates. Consistent with other N-acetyltransferases, Fus-2 localizes to the cytoplasm, as shown by GFP-tag experiments. Since the Fus-2 gene maps to the chromosomal region 3p21.3, which contains at least one tumour suppressor gene, the N-acetyltransferase functions of Fus-2 may be relevant to its potential role in cancer.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  • Bannister AJ and Kouzarides T . 1996 Nature 384: 641–643.

  • Bradshaw RA, Brickley WW and Walker KW . 1998 TIBS 23: 263–267.

  • Brauch H, Tory K, Kotler F, Gazdar AF, Pettengill OS, Johnson B, Graziano S, Winton T, Buys CH and Sorenson GD . 1990 Genes Chromosomes Cancer 1: 240–246.

  • Cascorbi I, Brockmoller J, Mrozikiewicz PM, Bauer S, Loddenkemper R and Roots I . 1996 Cancer Res 56: 3961–3966.

  • Dutnall RN, Tafrov ST, Sternglanz R and Ramakrishnan V . 1998 Cell 94: 427–438.

  • Grunstein M . 1997 Nature 389: 349–352.

  • Hibi K, Takahashi T, Yamakawa K, Ueda R, Sekido Y, Ariyoshi Y, Suyama M, Takagi H, Nakamura Y and Takahashi T . 1992 Oncogene 7: 445–449.

  • Johnson GG, Kronert WA, Bernstein SI, Chapman VM and Smith KD . 1988 J Biol Chem 263: 9079–9082.

  • Jornvall H, Fairwell T, Kratofil P and Wills C . 1980 FEBS Lett 111: 214–218.

  • Kok K, van den Berg A, Veldhuis PM, van der Veen AY, Franke M, Schoenmakers EF, Hulsbeek MM, van der Hout AH, de Leij L, van de Ven W and Buys CH . 1994 Cancer Res 54: 4183–4187.

  • Kouzarides T . 1999 Curr Opin Genet Dev 9: 40–48.

  • Mullen JR, Kayne PS, Moerschell RP, Tsunasawa S, Gribskov M, Colavito-Shepanski M, Grunstein M, Sherman F and Sternglanz R . 1989 EMBO J 8: 2067–2075.

  • Naylor SL, Johnson BE, Minna JD and Sakaguchi AY . 1987 Nature 329: 451–454.

  • Neuwald AF and Landsman D . 1997 Trends Biochem Sci 22: 154–155.

  • Wei MH, Latif F, Bader S, Kashuba V, Chen JY, Duh FM, Sekido Y, Lee CC, Geil L, Kuzmin I, Zabarovsky E, Klein G, Zbar B, Minna JD and Lerman MI . 1996 Cancer Res 56: 1487–1492.

  • Whang-Peng J, Kao-Shan CS, Lee EC, Bunn PA, Carney DN, Gazdar AF and Minna JD . 1982 Science 215: 181–182.

  • Wong LJ and Wong SS . 1983 Biochemistry 42: 4637–4641.

  • Zenser TV, Lakshmi VM, Rustan TD, Doll MA, Deitz AC, Davis BB and Hein DW . 1996 Cancer Res 56: 3941–3947.

Download references

Acknowledgements

We are grateful to Dr M Lerman for sending Cosmid LUCA-14 which contained the genomic Fus-2 DNA. We are also grateful to Nicole den Elzen and John Pines for supplying the GFP plasmids. This work was supported by grant (SP2081/0101) from the Cancer Research Campaign.

Author information

Authors and Affiliations

  1. Wellcome/CRC Institute and Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QR, UK

    Philip Zegerman, Andrew J Bannister & Tony Kouzarides

Authors
  1. Philip Zegerman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrew J Bannister
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tony Kouzarides
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zegerman, P., Bannister, A. & Kouzarides, T. The putative tumour suppressor Fus-2 is an N-acetyltransferase. Oncogene 19, 161–163 (2000). https://doi.org/10.1038/sj.onc.1203234

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1203234

Keywords

Search

Advanced search

Quick links