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Growth factor signaling pathways in vascular development

Oncogene volume 18, pages 7917–7932 (1999)Cite this article

Abstract

Recent research on the formation and maintenance of the vasculature in the embryo and in the adult has provided a greater understanding of the cellular signals involved in these processes. With this understanding comes the potential means of controlling vascularization in pathological situations such as tumorigenesis and wounding. For the purpose of this review, we will discuss the key receptor tyrosine kinases involved in vascular function and the molecules which relay signals downstream of receptor activation. The receptor tyrosine kinases discussed include the vascular endothelial cell growth factor receptors, Eph receptors, Tie1, and Tie2, all of which are expressed on vascular endothelial cells. We also discuss the roles of the platelet derived growth factor receptors which are expressed on vascular smooth muscle cells. While all of these receptor tyrosine kinases activate many similar effector molecules, some of the signals initiated appear to be distinct. This may explain, at least in part, how different receptor tyrosine kinases expressed in overlapping patterns on the developing vasculature, direct unique biological functions.

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Acknowledgements

Vascular development involves many signaling pathways, and we have only focused this review on a few of these pathways. We apologize to the authors whose work we failed to cite due to space constraints. MD Tallquist is supported by a fellowship from the American Cancer Society. RA Klinghoffer is supported by National Institutes of Health (NIH) postdoctoral fellowship HD08412. Work from the authors' laboratory is supported by grants HD24875 and HD25326 from NICHD to P Soriano.

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  1. Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, 98109, Washington, WA, USA

    Michelle D Tallquist, Philippe Soriano & Richard A Klinghoffer

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  1. Michelle D Tallquist
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  2. Philippe Soriano
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  3. Richard A Klinghoffer
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Tallquist, M., Soriano, P. & Klinghoffer, R. Growth factor signaling pathways in vascular development. Oncogene 18, 7917–7932 (1999). https://doi.org/10.1038/sj.onc.1203216

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